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Resveratrol Attenuates Oxidative Stress and Extends Life Span in the Annual Fish Nothobranchius guentheri.
Rejuvenation Res 2015; 18(3):225-33RR

Abstract

Resveratrol is a natural polyphenol derived mainly from the skin of grapes and from red wine. Resveratrol prolongs life span in several invertebrates, but this function is not found in mice. Our recently published paper demonstrated that resveratrol prolonged longevity of the annual fish Nothobranchius guentheri, a promising vertebrate model for anti-aging research. However, the anti-aging process by resveratrol remains largely unexplored, and little is known about its effects on oxidative stress. In this study, by long-term supplementation of resveratrol from sexual maturity onward in the annual fish, we detected survivorship and oxidative stress at three different developmental stages in vivo. A total of 112 fish were fed with resveratrol in the concentration of 200 μg/gram food and 111 fish without resveratrol from 16 weeks of age until to the end of their lives. The mean and maximum life spans of the fish treated with resveratrol were extended by 17.34% and 17.66%, respectively, compared to the fish in control group. The markers of oxidative stress, such as the levels of reactive oxygen species (ROS), the activities of anti-oxidant enzymes, and the degree of oxidative damage, were detected at 6, 9, and 12 months, respectively. The results showed that levels of ROS and oxidative damage increased and activities of anti-oxidant enzymes appeared to decrease with age. Resveratrol treatment significantly attenuated the increase of ROS and oxidative damage and up-regulated the decrease of anti-oxidant enzyme activities induced by aging. Our results demonstrated that resveratrol decreased oxidative stress and extended life span in this short-lived fish.

Authors+Show Affiliations

Shandong Provincial Key Laboratory of Animal Resistant Biology, School of Life Sciences, Shandong Normal University , Jinan, China .Shandong Provincial Key Laboratory of Animal Resistant Biology, School of Life Sciences, Shandong Normal University , Jinan, China .Shandong Provincial Key Laboratory of Animal Resistant Biology, School of Life Sciences, Shandong Normal University , Jinan, China .Shandong Provincial Key Laboratory of Animal Resistant Biology, School of Life Sciences, Shandong Normal University , Jinan, China .Shandong Provincial Key Laboratory of Animal Resistant Biology, School of Life Sciences, Shandong Normal University , Jinan, China .Shandong Provincial Key Laboratory of Animal Resistant Biology, School of Life Sciences, Shandong Normal University , Jinan, China .Shandong Provincial Key Laboratory of Animal Resistant Biology, School of Life Sciences, Shandong Normal University , Jinan, China .Shandong Provincial Key Laboratory of Animal Resistant Biology, School of Life Sciences, Shandong Normal University , Jinan, China .Shandong Provincial Key Laboratory of Animal Resistant Biology, School of Life Sciences, Shandong Normal University , Jinan, China .

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25569124

Citation

Liu, Tingting, et al. "Resveratrol Attenuates Oxidative Stress and Extends Life Span in the Annual Fish Nothobranchius Guentheri." Rejuvenation Research, vol. 18, no. 3, 2015, pp. 225-33.
Liu T, Qi H, Ma L, et al. Resveratrol Attenuates Oxidative Stress and Extends Life Span in the Annual Fish Nothobranchius guentheri. Rejuvenation Res. 2015;18(3):225-33.
Liu, T., Qi, H., Ma, L., Liu, Z., Fu, H., Zhu, W., ... Li, G. (2015). Resveratrol Attenuates Oxidative Stress and Extends Life Span in the Annual Fish Nothobranchius guentheri. Rejuvenation Research, 18(3), pp. 225-33. doi:10.1089/rej.2014.1618.
Liu T, et al. Resveratrol Attenuates Oxidative Stress and Extends Life Span in the Annual Fish Nothobranchius Guentheri. Rejuvenation Res. 2015;18(3):225-33. PubMed PMID: 25569124.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Resveratrol Attenuates Oxidative Stress and Extends Life Span in the Annual Fish Nothobranchius guentheri. AU - Liu,Tingting, AU - Qi,He, AU - Ma,Long, AU - Liu,Zhaojun, AU - Fu,Huiling, AU - Zhu,Wenzhen, AU - Song,Taiyu, AU - Yang,Bingwu, AU - Li,Guorong, Y1 - 2015/05/20/ PY - 2015/1/9/entrez PY - 2015/1/9/pubmed PY - 2016/3/16/medline SP - 225 EP - 33 JF - Rejuvenation research JO - Rejuvenation Res VL - 18 IS - 3 N2 - Resveratrol is a natural polyphenol derived mainly from the skin of grapes and from red wine. Resveratrol prolongs life span in several invertebrates, but this function is not found in mice. Our recently published paper demonstrated that resveratrol prolonged longevity of the annual fish Nothobranchius guentheri, a promising vertebrate model for anti-aging research. However, the anti-aging process by resveratrol remains largely unexplored, and little is known about its effects on oxidative stress. In this study, by long-term supplementation of resveratrol from sexual maturity onward in the annual fish, we detected survivorship and oxidative stress at three different developmental stages in vivo. A total of 112 fish were fed with resveratrol in the concentration of 200 μg/gram food and 111 fish without resveratrol from 16 weeks of age until to the end of their lives. The mean and maximum life spans of the fish treated with resveratrol were extended by 17.34% and 17.66%, respectively, compared to the fish in control group. The markers of oxidative stress, such as the levels of reactive oxygen species (ROS), the activities of anti-oxidant enzymes, and the degree of oxidative damage, were detected at 6, 9, and 12 months, respectively. The results showed that levels of ROS and oxidative damage increased and activities of anti-oxidant enzymes appeared to decrease with age. Resveratrol treatment significantly attenuated the increase of ROS and oxidative damage and up-regulated the decrease of anti-oxidant enzyme activities induced by aging. Our results demonstrated that resveratrol decreased oxidative stress and extended life span in this short-lived fish. SN - 1557-8577 UR - https://www.unboundmedicine.com/medline/citation/25569124/Resveratrol_Attenuates_Oxidative_Stress_and_Extends_Life_Span_in_the_Annual_Fish_Nothobranchius_guentheri_ L2 - https://www.liebertpub.com/doi/full/10.1089/rej.2014.1618?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -