Tags

Type your tag names separated by a space and hit enter

Does MAP2 have a role in predicting the development of anti-NMDAR encephalitis associated with benign ovarian teratoma? A report of six new pediatric cases.
Pediatr Dev Pathol. 2015 Mar-Apr; 18(2):122-6.PD

Abstract

Anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis is a potentially fatal neurologic syndrome in which patients present with a spectrum of central nervous system deficits. Sixty percent of the cases can be attributed to the presence of tumors, most often ovarian teratomas. This report examines 6 pediatric patients who presented with neurologic deficits associated with the presence of such tumors. These cases illustrate a perplexing phenomenon, where benign teratomas could have a possible association with anti-NMDAR encephalitis. The purpose of this study was to compare the histology and immunohistochemistry of tumors associated with this syndrome to ovarian teratomas found in patients presenting with no neurologic symptoms. After obtaining institutional review board approval, 57 cases of ovarian teratomas were identified at our institution over 12 years. Six patients were identified with anti-NMDAR encephalitis. A panel of immunostains, including S100, GFAP, MAP2, and NeuN was applied to patients' tumor sections as well as the 6 controls from age-matched patients. No qualitative histologic or immunohistochemical differences were seen between the study cases and control group. Because no qualitative differences were identified between the study cases and the control group, testing of paired serum and cerebrospinal fluid remains the best method for diagnosis of anti-NMDAR encephalitis. Tumor banking with molecular analysis of ovarian teratomas, including whole-genome sequencing and comparative genomic hybridization between ovarian tissue saved from patients with and without anti-NMDAR encephalitis, is necessary to fully understand the etiopathogenesis of anti-NMDAR encephalitis.

Authors+Show Affiliations

1 Department of Pathology, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25569473

Citation

Cundiff, Caitlin A., et al. "Does MAP2 Have a Role in Predicting the Development of anti-NMDAR Encephalitis Associated With Benign Ovarian Teratoma? a Report of Six New Pediatric Cases." Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, vol. 18, no. 2, 2015, pp. 122-6.
Cundiff CA, Elawabdeh N, Naguib MM, et al. Does MAP2 have a role in predicting the development of anti-NMDAR encephalitis associated with benign ovarian teratoma? A report of six new pediatric cases. Pediatr Dev Pathol. 2015;18(2):122-6.
Cundiff, C. A., Elawabdeh, N., Naguib, M. M., Jactel, S. N., Demellawy, D. E., Abramowsky, C. R., Durham, M. M., Youssef, L., Wittkamp, M. L., & Shehata, B. M. (2015). Does MAP2 have a role in predicting the development of anti-NMDAR encephalitis associated with benign ovarian teratoma? A report of six new pediatric cases. Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, 18(2), 122-6. https://doi.org/10.2350/14-09-1554-OA.1
Cundiff CA, et al. Does MAP2 Have a Role in Predicting the Development of anti-NMDAR Encephalitis Associated With Benign Ovarian Teratoma? a Report of Six New Pediatric Cases. Pediatr Dev Pathol. 2015 Mar-Apr;18(2):122-6. PubMed PMID: 25569473.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does MAP2 have a role in predicting the development of anti-NMDAR encephalitis associated with benign ovarian teratoma? A report of six new pediatric cases. AU - Cundiff,Caitlin A, AU - Elawabdeh,Nancy, AU - Naguib,Mina M, AU - Jactel,Samuel N, AU - Demellawy,Dina El, AU - Abramowsky,Carlos R, AU - Durham,Megan M, AU - Youssef,Lara, AU - Wittkamp,Michael L, AU - Shehata,Bahig M, Y1 - 2015/01/08/ PY - 2015/1/9/entrez PY - 2015/1/9/pubmed PY - 2015/5/20/medline KW - MAP2 KW - NeuN KW - anti-NMDAR KW - encephalitis KW - neuronal markers KW - ovarian teratoma SP - 122 EP - 6 JF - Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society JO - Pediatr Dev Pathol VL - 18 IS - 2 N2 - Anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis is a potentially fatal neurologic syndrome in which patients present with a spectrum of central nervous system deficits. Sixty percent of the cases can be attributed to the presence of tumors, most often ovarian teratomas. This report examines 6 pediatric patients who presented with neurologic deficits associated with the presence of such tumors. These cases illustrate a perplexing phenomenon, where benign teratomas could have a possible association with anti-NMDAR encephalitis. The purpose of this study was to compare the histology and immunohistochemistry of tumors associated with this syndrome to ovarian teratomas found in patients presenting with no neurologic symptoms. After obtaining institutional review board approval, 57 cases of ovarian teratomas were identified at our institution over 12 years. Six patients were identified with anti-NMDAR encephalitis. A panel of immunostains, including S100, GFAP, MAP2, and NeuN was applied to patients' tumor sections as well as the 6 controls from age-matched patients. No qualitative histologic or immunohistochemical differences were seen between the study cases and control group. Because no qualitative differences were identified between the study cases and the control group, testing of paired serum and cerebrospinal fluid remains the best method for diagnosis of anti-NMDAR encephalitis. Tumor banking with molecular analysis of ovarian teratomas, including whole-genome sequencing and comparative genomic hybridization between ovarian tissue saved from patients with and without anti-NMDAR encephalitis, is necessary to fully understand the etiopathogenesis of anti-NMDAR encephalitis. SN - 1093-5266 UR - https://www.unboundmedicine.com/medline/citation/25569473/Does_MAP2_have_a_role_in_predicting_the_development_of_anti_NMDAR_encephalitis_associated_with_benign_ovarian_teratoma_A_report_of_six_new_pediatric_cases_ L2 - https://journals.sagepub.com/doi/10.2350/14-09-1554-OA.1?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -