Tags

Type your tag names separated by a space and hit enter

Selenium status in U.K. pregnant women and its relationship with hypertensive conditions of pregnancy.
Br J Nutr 2015; 113(2):249-58BJ

Abstract

Dietary intake/status of the trace mineral Se may affect the risk of developing hypertensive conditions of pregnancy, i.e. pre-eclampsia and pregnancy-induced hypertension (PE/PIH). In the present study, we evaluated Se status in U.K. pregnant women to establish whether pre-pregnant Se status or Se supplementation affected the risk of developing PE/PIH. The samples originated from the SPRINT (Selenium in PRegnancy INTervention) study that randomised 230 U.K. primiparous women to treatment with Se (60 μg/d) or placebo from 12 weeks of gestation. Whole-blood Se concentration was measured at 12 and 35 weeks, toenail Se concentration at 16 weeks, plasma selenoprotein P (SEPP1) concentration at 35 weeks and plasma glutathione peroxidase (GPx3) activity at 12, 20 and 35 weeks. Demographic data were collected at baseline. Participants completed a FFQ. U.K. pregnant women had whole-blood Se concentration lower than the mid-range of other populations, toenail Se concentration considerably lower than U.S. women, GPx3 activity considerably lower than U.S. and Australian pregnant women, and low baseline SEPP1 concentration (median 3.00, range 0.90-5.80 mg/l). Maternal age, education and social class were positively associated with Se status. After adjustment, whole-blood Se concentration was higher in women consuming Brazil nuts (P= 0.040) and in those consuming more than two seafood portions per week (P= 0.054). A stepwise logistic regression model revealed that among the Se-related risk factors, only toenail Se (OR 0.38, 95% CI 0.17, 0.87, P= 0.021) significantly affected the OR for PE/PIH. On excluding non-compliers with Se treatment, Se supplementation also significantly reduced the OR for PE/PIH (OR 0.30, 95% CI 0.09, 1.00, P= 0.049). In conclusion, U.K. women have low Se status that increases their risk of developing PE/PIH. Therefore, U.K. women of childbearing age need to improve their Se status.

Authors+Show Affiliations

Department of Nutritional Sciences,Faculty of Health and Medical Sciences, School of Biosciences and Medicine, University of Surrey,GuildfordGU2 7XH,UK.Department of Nutritional Sciences,Faculty of Health and Medical Sciences, School of Biosciences and Medicine, University of Surrey,GuildfordGU2 7XH,UK.School of Medical Science, Griffith Health Institute, Griffith University,Queensland,QLD4222,Australia.Department of Mathematics,Faculty of Engineering and Physical Sciences, University of Surrey,GuildfordGU2 7XH,UK.Department of Nutritional Sciences,Faculty of Health and Medical Sciences, School of Biosciences and Medicine, University of Surrey,GuildfordGU2 7XH,UK.School of Medical Science, Griffith Health Institute, Griffith University,Queensland,QLD4222,Australia.School of Medical Science, Griffith Health Institute, Griffith University,Queensland,QLD4222,Australia.Nuffield Department of Obstetrics and Gynaecology, University of Oxford,OxfordOX3 9DU,UK.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25571960

Citation

Rayman, Margaret P., et al. "Selenium Status in U.K. Pregnant Women and Its Relationship With Hypertensive Conditions of Pregnancy." The British Journal of Nutrition, vol. 113, no. 2, 2015, pp. 249-58.
Rayman MP, Bath SC, Westaway J, et al. Selenium status in U.K. pregnant women and its relationship with hypertensive conditions of pregnancy. Br J Nutr. 2015;113(2):249-58.
Rayman, M. P., Bath, S. C., Westaway, J., Williams, P., Mao, J., Vanderlelie, J. J., ... Redman, C. W. (2015). Selenium status in U.K. pregnant women and its relationship with hypertensive conditions of pregnancy. The British Journal of Nutrition, 113(2), pp. 249-58. doi:10.1017/S000711451400364X.
Rayman MP, et al. Selenium Status in U.K. Pregnant Women and Its Relationship With Hypertensive Conditions of Pregnancy. Br J Nutr. 2015 Jan 28;113(2):249-58. PubMed PMID: 25571960.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selenium status in U.K. pregnant women and its relationship with hypertensive conditions of pregnancy. AU - Rayman,Margaret P, AU - Bath,Sarah C, AU - Westaway,Jacob, AU - Williams,Peter, AU - Mao,Jinyuan, AU - Vanderlelie,Jessica J, AU - Perkins,Anthony V, AU - Redman,Christopher W G, Y1 - 2015/01/09/ PY - 2015/1/10/entrez PY - 2015/1/13/pubmed PY - 2016/8/16/medline KW - Hypertension KW - Hypertensive conditions of pregnancy KW - Pregnancy KW - Selenium status SP - 249 EP - 58 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 113 IS - 2 N2 - Dietary intake/status of the trace mineral Se may affect the risk of developing hypertensive conditions of pregnancy, i.e. pre-eclampsia and pregnancy-induced hypertension (PE/PIH). In the present study, we evaluated Se status in U.K. pregnant women to establish whether pre-pregnant Se status or Se supplementation affected the risk of developing PE/PIH. The samples originated from the SPRINT (Selenium in PRegnancy INTervention) study that randomised 230 U.K. primiparous women to treatment with Se (60 μg/d) or placebo from 12 weeks of gestation. Whole-blood Se concentration was measured at 12 and 35 weeks, toenail Se concentration at 16 weeks, plasma selenoprotein P (SEPP1) concentration at 35 weeks and plasma glutathione peroxidase (GPx3) activity at 12, 20 and 35 weeks. Demographic data were collected at baseline. Participants completed a FFQ. U.K. pregnant women had whole-blood Se concentration lower than the mid-range of other populations, toenail Se concentration considerably lower than U.S. women, GPx3 activity considerably lower than U.S. and Australian pregnant women, and low baseline SEPP1 concentration (median 3.00, range 0.90-5.80 mg/l). Maternal age, education and social class were positively associated with Se status. After adjustment, whole-blood Se concentration was higher in women consuming Brazil nuts (P= 0.040) and in those consuming more than two seafood portions per week (P= 0.054). A stepwise logistic regression model revealed that among the Se-related risk factors, only toenail Se (OR 0.38, 95% CI 0.17, 0.87, P= 0.021) significantly affected the OR for PE/PIH. On excluding non-compliers with Se treatment, Se supplementation also significantly reduced the OR for PE/PIH (OR 0.30, 95% CI 0.09, 1.00, P= 0.049). In conclusion, U.K. women have low Se status that increases their risk of developing PE/PIH. Therefore, U.K. women of childbearing age need to improve their Se status. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/25571960/Selenium_status_in_U_K__pregnant_women_and_its_relationship_with_hypertensive_conditions_of_pregnancy_ L2 - http://journals.cambridge.org/abstract_S000711451400364X DB - PRIME DP - Unbound Medicine ER -