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Role of omega-3 fatty acids and their metabolites in asthma and allergic diseases.
Allergol Int. 2015 Jan; 64(1):27-34.AI

Abstract

Omega-3 fatty acids, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), are found naturally in fish oil and are commonly thought to be anti-inflammatory nutrients, with protective effects in inflammatory diseases including asthma and allergies. The mechanisms of these effects remain mostly unknown but are of great interest for their potential therapeutic applications. Large numbers of epidemiological and observational studies investigating the effect of fish intake or omega-3 fatty acid supplementation during pregnancy, lactation, infancy, childhood, and adulthood on asthmatic and allergic outcomes have been conducted. They mostly indicate protective effects and suggest a causal relationship between decreased intake of fish oil in modernized diets and an increasing number of individuals with asthma or other allergic diseases. Specialized pro-resolving mediators (SPM: protectins, resolvins, and maresins) are generated from omega-3 fatty acids such as EPA and DHA via several enzymatic reactions. These mediators counter-regulate airway eosinophilic inflammation and promote the resolution of inflammation in vivo. Several reports have indicated that the biosynthesis of SPM is impaired, especially in severe asthma, which suggests that chronic inflammation in the lung might result from a resolution defect. This article focuses on the beneficial aspects of omega-3 fatty acids and offers recent insights into their bioactive metabolites including resolvins and protectins.

Authors+Show Affiliations

Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan. Electronic address: jun.miyata@riken.jp.Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan; Graduate School of Medical Life Science, Yokohama City University, Kanagawa, Japan.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25572556

Citation

Miyata, Jun, and Makoto Arita. "Role of Omega-3 Fatty Acids and Their Metabolites in Asthma and Allergic Diseases." Allergology International : Official Journal of the Japanese Society of Allergology, vol. 64, no. 1, 2015, pp. 27-34.
Miyata J, Arita M. Role of omega-3 fatty acids and their metabolites in asthma and allergic diseases. Allergol Int. 2015;64(1):27-34.
Miyata, J., & Arita, M. (2015). Role of omega-3 fatty acids and their metabolites in asthma and allergic diseases. Allergology International : Official Journal of the Japanese Society of Allergology, 64(1), 27-34. https://doi.org/10.1016/j.alit.2014.08.003
Miyata J, Arita M. Role of Omega-3 Fatty Acids and Their Metabolites in Asthma and Allergic Diseases. Allergol Int. 2015;64(1):27-34. PubMed PMID: 25572556.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of omega-3 fatty acids and their metabolites in asthma and allergic diseases. AU - Miyata,Jun, AU - Arita,Makoto, Y1 - 2014/10/27/ PY - 2014/08/01/received PY - 2014/08/20/revised PY - 2014/08/21/accepted PY - 2015/1/10/entrez PY - 2015/1/13/pubmed PY - 2015/12/15/medline KW - Allergy KW - Asthma KW - Omega-3 fatty acid KW - Protectin KW - Specialized pro-resolving mediator SP - 27 EP - 34 JF - Allergology international : official journal of the Japanese Society of Allergology JO - Allergol Int VL - 64 IS - 1 N2 - Omega-3 fatty acids, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), are found naturally in fish oil and are commonly thought to be anti-inflammatory nutrients, with protective effects in inflammatory diseases including asthma and allergies. The mechanisms of these effects remain mostly unknown but are of great interest for their potential therapeutic applications. Large numbers of epidemiological and observational studies investigating the effect of fish intake or omega-3 fatty acid supplementation during pregnancy, lactation, infancy, childhood, and adulthood on asthmatic and allergic outcomes have been conducted. They mostly indicate protective effects and suggest a causal relationship between decreased intake of fish oil in modernized diets and an increasing number of individuals with asthma or other allergic diseases. Specialized pro-resolving mediators (SPM: protectins, resolvins, and maresins) are generated from omega-3 fatty acids such as EPA and DHA via several enzymatic reactions. These mediators counter-regulate airway eosinophilic inflammation and promote the resolution of inflammation in vivo. Several reports have indicated that the biosynthesis of SPM is impaired, especially in severe asthma, which suggests that chronic inflammation in the lung might result from a resolution defect. This article focuses on the beneficial aspects of omega-3 fatty acids and offers recent insights into their bioactive metabolites including resolvins and protectins. SN - 1440-1592 UR - https://www.unboundmedicine.com/medline/citation/25572556/Role_of_omega_3_fatty_acids_and_their_metabolites_in_asthma_and_allergic_diseases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1323-8930(14)00010-0 DB - PRIME DP - Unbound Medicine ER -