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Daily intake of bisphenol A and triclosan and their association with anthropometric data, thyroid hormones and weight loss in overweight and obese individuals.
Environ Int. 2015 Mar; 76:98-105.EI

Abstract

Bisphenol A (BPA) and triclosan (TCS) were determined in urine of Belgian overweight and obese (n=151) and lean (n=43) individuals. After the first urine collection (0M), obese patients started a diet program or have undergone bariatric surgery. Hereafter, three additional urine samples from obese patients were collected after 3 (3M), 6 (6M) and 12 (12M) months. Both compounds were detected in >99% of the samples. BPA had median concentrations of 1.7 and 1.2ng/mL in obese and lean groups, respectively, while TCS had median concentrations of 1.5 and 0.9ng/mL in the obese and lean groups, respectively. The obese group had higher urinary concentrations (ng/mL) of BPA (p<0.5), while no significant differences were found for TCS between the obese and lean groups. No time trends between the different collection moments were observed. The BPA concentrations in the obese group were negatively associated with age, while no gender difference or relationship with body mass index was observed. For TCS, no relationships with gender, BMI, or age were found. The temporal variability of BPA and TCS was assessed with calculation of the intraclass correlation coefficient, Spearman rank correlation coefficients, and surrogate category analysis. We observed evidence that single spot urine samples might be predictive of exposure over a longer period of time. Dietary intakes of BPA and TCS did not differ significantly among the time points considered after obese individuals started losing weight (6 and 12months). Multiple linear regression analyses after adjusting for age and weight loss revealed negative associations between urinary TCS and serum FT4 in the 0M and 3M female obese individuals and positive associations between urinary BPA and serum TSH in the lean group.

Authors+Show Affiliations

Toxicological Centre, University of Antwerp, 2610 Wilrijk, Antwerp, Belgium.Toxicological Centre, University of Antwerp, 2610 Wilrijk, Antwerp, Belgium.Department of Endocrinology, Diabetology and Metabolic Disease, University of Antwerp and Antwerp University Hospital, 2630 Edegem, Antwerp, Belgium.Toxicological Centre, University of Antwerp, 2610 Wilrijk, Antwerp, Belgium.Department of Endocrinology, Diabetology and Metabolic Disease, University of Antwerp and Antwerp University Hospital, 2630 Edegem, Antwerp, Belgium.Department of Clinical Pharmacology, University of Antwerp and Antwerp University Hospital, 2630 Edegem, Antwerp, Belgium.Toxicological Centre, University of Antwerp, 2610 Wilrijk, Antwerp, Belgium. Electronic address: adrian.covaci@uantwerpen.be.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25575039

Citation

Geens, Tinne, et al. "Daily Intake of Bisphenol a and Triclosan and Their Association With Anthropometric Data, Thyroid Hormones and Weight Loss in Overweight and Obese Individuals." Environment International, vol. 76, 2015, pp. 98-105.
Geens T, Dirtu AC, Dirinck E, et al. Daily intake of bisphenol A and triclosan and their association with anthropometric data, thyroid hormones and weight loss in overweight and obese individuals. Environ Int. 2015;76:98-105.
Geens, T., Dirtu, A. C., Dirinck, E., Malarvannan, G., Van Gaal, L., Jorens, P. G., & Covaci, A. (2015). Daily intake of bisphenol A and triclosan and their association with anthropometric data, thyroid hormones and weight loss in overweight and obese individuals. Environment International, 76, 98-105. https://doi.org/10.1016/j.envint.2014.12.003
Geens T, et al. Daily Intake of Bisphenol a and Triclosan and Their Association With Anthropometric Data, Thyroid Hormones and Weight Loss in Overweight and Obese Individuals. Environ Int. 2015;76:98-105. PubMed PMID: 25575039.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Daily intake of bisphenol A and triclosan and their association with anthropometric data, thyroid hormones and weight loss in overweight and obese individuals. AU - Geens,Tinne, AU - Dirtu,Alin C, AU - Dirinck,Eveline, AU - Malarvannan,Govindan, AU - Van Gaal,Luc, AU - Jorens,Philippe G, AU - Covaci,Adrian, Y1 - 2015/01/06/ PY - 2014/07/24/received PY - 2014/11/05/revised PY - 2014/12/08/accepted PY - 2015/1/10/entrez PY - 2015/1/13/pubmed PY - 2015/7/15/medline KW - Belgium KW - Bisphenol A KW - Obesity KW - Triclosan KW - Urine KW - Weight loss SP - 98 EP - 105 JF - Environment international JO - Environ Int VL - 76 N2 - Bisphenol A (BPA) and triclosan (TCS) were determined in urine of Belgian overweight and obese (n=151) and lean (n=43) individuals. After the first urine collection (0M), obese patients started a diet program or have undergone bariatric surgery. Hereafter, three additional urine samples from obese patients were collected after 3 (3M), 6 (6M) and 12 (12M) months. Both compounds were detected in >99% of the samples. BPA had median concentrations of 1.7 and 1.2ng/mL in obese and lean groups, respectively, while TCS had median concentrations of 1.5 and 0.9ng/mL in the obese and lean groups, respectively. The obese group had higher urinary concentrations (ng/mL) of BPA (p<0.5), while no significant differences were found for TCS between the obese and lean groups. No time trends between the different collection moments were observed. The BPA concentrations in the obese group were negatively associated with age, while no gender difference or relationship with body mass index was observed. For TCS, no relationships with gender, BMI, or age were found. The temporal variability of BPA and TCS was assessed with calculation of the intraclass correlation coefficient, Spearman rank correlation coefficients, and surrogate category analysis. We observed evidence that single spot urine samples might be predictive of exposure over a longer period of time. Dietary intakes of BPA and TCS did not differ significantly among the time points considered after obese individuals started losing weight (6 and 12months). Multiple linear regression analyses after adjusting for age and weight loss revealed negative associations between urinary TCS and serum FT4 in the 0M and 3M female obese individuals and positive associations between urinary BPA and serum TSH in the lean group. SN - 1873-6750 UR - https://www.unboundmedicine.com/medline/citation/25575039/Daily_intake_of_bisphenol_A_and_triclosan_and_their_association_with_anthropometric_data_thyroid_hormones_and_weight_loss_in_overweight_and_obese_individuals_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0160-4120(14)00358-4 DB - PRIME DP - Unbound Medicine ER -