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Scrub typhus caused by Orientia tsutsugamushi Kawasaki-related genotypes in Shandong Province, northern China.
Infect Genet Evol. 2015 Mar; 30:238-243.IG

Abstract

Orientia tsutsugamushi, the causative agent of scrub typhus, is an obligate intracellular bacterium and characterized by dramatic genetic diversity. To elucidate the genotypes of O. tsutsugamushi populating in patients in Shandong Province, a new epidemic zone in China, we sequenced partial of the 56-kDa type-specific antigen gene (TSA) and identified the genotypes of 43 O. tsutsugamushi samples from human patients confirmed with scrub typhus from 2010 to 2013. All of the 43 sequences are in the same clade, 39 of them are in one branch and the other four sequences, nominated as SH1002, SH1306, SH1309, and SH1307 are in four separate branches. To clarify the clinical characterizations caused by Kawasaki-related genotypes, we studied the clinical profiles of these 43 scrub typhus patients. Most patients (88.1%) were farmers lived in rural areas. They presented with fever (100.0%), headache (79.1%), dizziness (32.6%), generalized myalgia (48.8%), fatigue (53.5%), anorexia (53.5%), facial flushing (23.3%), conjunctival congestion (11.6%), skin rashes (58.1%) and lymphadenopathy (23.3%). Eschar (97.7%) was quite common in patients, which provided doctors with a luminous clue for diagnosis of scrub typhus. Thrombocytopenia was seen in 23.1% of patients, and three patients (7.0%) had bronchopneumonia. There was no death report in Shandong Province during the study period. The present study provides beneficial data for clinical, serological, and molecular diagnosis of scrub typhus infections, and also provides foundations for subsequent studies.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Zhang L
Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, 44 Wenhuaxi Road, Jinan 250012, China.
Bi Z
Institute for Bacterial Infectious Disease Control and Prevention, Shandong Center for Disease Control and Prevention, Jinan 250012, China.
Kou Z
Institute for Bacterial Infectious Disease Control and Prevention, Shandong Center for Disease Control and Prevention, Jinan 250012, China.
Yang H
Tai'an Center for Disease Control and Prevention, Tai'an 271000, China.
Zhang A
Tai'an Center for Disease Control and Prevention, Tai'an 271000, China.
Zhang S
Yiyuan Center for Disease Control and Prevention, Zibo 256100, China.
Meng X
Tai'an Center for Disease Control and Prevention, Tai'an 271000, China.
Zheng L
Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, 44 Wenhuaxi Road, Jinan 250012, China.
Zhang M
Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, 44 Wenhuaxi Road, Jinan 250012, China.
Yang H
Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, 44 Wenhuaxi Road, Jinan 250012, China.
Zhao Z
Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, 44 Wenhuaxi Road, Jinan 250012, China. Electronic address: ztzhao@sdu.edu.cn.

MeSH

AdultAgedAntigens, BacterialChinaEpidemicsFemaleHumansMaleMiddle AgedMolecular EpidemiologyOrientia tsutsugamushiPhylogenyScrub Typhus

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25575441

Citation

Zhang, Luyan, et al. "Scrub Typhus Caused By Orientia Tsutsugamushi Kawasaki-related Genotypes in Shandong Province, Northern China." Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases, vol. 30, 2015, pp. 238-243.
Zhang L, Bi Z, Kou Z, et al. Scrub typhus caused by Orientia tsutsugamushi Kawasaki-related genotypes in Shandong Province, northern China. Infect Genet Evol. 2015;30:238-243.
Zhang, L., Bi, Z., Kou, Z., Yang, H., Zhang, A., Zhang, S., Meng, X., Zheng, L., Zhang, M., Yang, H., & Zhao, Z. (2015). Scrub typhus caused by Orientia tsutsugamushi Kawasaki-related genotypes in Shandong Province, northern China. Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases, 30, 238-243. https://doi.org/10.1016/j.meegid.2014.12.036
Zhang L, et al. Scrub Typhus Caused By Orientia Tsutsugamushi Kawasaki-related Genotypes in Shandong Province, Northern China. Infect Genet Evol. 2015;30:238-243. PubMed PMID: 25575441.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Scrub typhus caused by Orientia tsutsugamushi Kawasaki-related genotypes in Shandong Province, northern China. AU - Zhang,Luyan, AU - Bi,Zhenwang, AU - Kou,Zengqiang, AU - Yang,Huili, AU - Zhang,Aihua, AU - Zhang,Shoufeng, AU - Meng,Xiangpeng, AU - Zheng,Li, AU - Zhang,Meng, AU - Yang,Hui, AU - Zhao,Zhongtang, Y1 - 2015/01/06/ PY - 2014/06/30/received PY - 2014/10/20/revised PY - 2014/12/30/accepted PY - 2015/1/11/entrez PY - 2015/1/13/pubmed PY - 2015/9/26/medline KW - 56-kDa type specific antigen gene KW - Orientia tsutsugamushi KW - Phylogenetic analysis KW - Scrub typhus SP - 238 EP - 243 JF - Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases JO - Infect Genet Evol VL - 30 N2 - Orientia tsutsugamushi, the causative agent of scrub typhus, is an obligate intracellular bacterium and characterized by dramatic genetic diversity. To elucidate the genotypes of O. tsutsugamushi populating in patients in Shandong Province, a new epidemic zone in China, we sequenced partial of the 56-kDa type-specific antigen gene (TSA) and identified the genotypes of 43 O. tsutsugamushi samples from human patients confirmed with scrub typhus from 2010 to 2013. All of the 43 sequences are in the same clade, 39 of them are in one branch and the other four sequences, nominated as SH1002, SH1306, SH1309, and SH1307 are in four separate branches. To clarify the clinical characterizations caused by Kawasaki-related genotypes, we studied the clinical profiles of these 43 scrub typhus patients. Most patients (88.1%) were farmers lived in rural areas. They presented with fever (100.0%), headache (79.1%), dizziness (32.6%), generalized myalgia (48.8%), fatigue (53.5%), anorexia (53.5%), facial flushing (23.3%), conjunctival congestion (11.6%), skin rashes (58.1%) and lymphadenopathy (23.3%). Eschar (97.7%) was quite common in patients, which provided doctors with a luminous clue for diagnosis of scrub typhus. Thrombocytopenia was seen in 23.1% of patients, and three patients (7.0%) had bronchopneumonia. There was no death report in Shandong Province during the study period. The present study provides beneficial data for clinical, serological, and molecular diagnosis of scrub typhus infections, and also provides foundations for subsequent studies. SN - 1567-7257 UR - https://www.unboundmedicine.com/medline/citation/25575441/Scrub_typhus_caused_by_Orientia_tsutsugamushi_Kawasaki_related_genotypes_in_Shandong_Province_northern_China_ DB - PRIME DP - Unbound Medicine ER -