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Alteration of cardiac ACE2/Mas expression and cardiac remodelling in rats with aortic constriction.
Chin J Physiol. 2014 Dec 31; 57(6):335-42.CJ

Abstract

The recent discovery of the new components of the renin-angiotensin system (RAS) suggests the importance of the maintenance of cardiovascular structure and functions. To assess the role of the angiotensin-converting enzyme 2 (ACE2)-Mas receptor axis in the regulation of cardiac structure and function, the present work investigated the expression of ACE2 and Mas receptor in the heart in the cardiac remodeling that occurs in aortic constricted rats. Partial abdominal aortic ligation was carried out in Sprague-Dawley rats. Angiotensin AT1 receptor blockade and ACE inhibition were achieved by losartan and enalapril treatment, respectively. Results showed that aortic constriction increased left ventricular hypertrophy, fibrosis, mean arterial pressure (MAP), plasma renin activity (PRA) and cardiac ACE levels, but decreased the expression of cardiac ACE2 and Mas receptor. Losartan treatment significantly decreased MAP, left ventricle hypertrophy (LVH), fibrosis, and increased cardiac ACE2 and Mas expression. Enalapril also improved the cardiac parameters with a rise in cardiac ACE2, but did not change the Mas level. In conclusion, aortic constriction results in cardiac hypertrophy, fibrosis and a rise of cardiac ACE expression. Both AT1 receptor blocker and ACE inhibitor play a cardioprotective role in aortic constriction. However, AT1 receptor blocker particularly promotes cardiac ACE2 and Mas receptor levels. ACE inhibitor is associated with the inhibition of ACE and normalization of cardiac ACE2 activity.

Authors+Show Affiliations

Department of Physiology, Institute of Neurobiology, Taishan Medical University, Taian 271000, Shandong, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25575522

Citation

Zhang, Yanling, et al. "Alteration of Cardiac ACE2/Mas Expression and Cardiac Remodelling in Rats With Aortic Constriction." The Chinese Journal of Physiology, vol. 57, no. 6, 2014, pp. 335-42.
Zhang Y, Li B, Wang B, et al. Alteration of cardiac ACE2/Mas expression and cardiac remodelling in rats with aortic constriction. Chin J Physiol. 2014;57(6):335-42.
Zhang, Y., Li, B., Wang, B., Zhang, J., Wu, J., & Morgan, T. (2014). Alteration of cardiac ACE2/Mas expression and cardiac remodelling in rats with aortic constriction. The Chinese Journal of Physiology, 57(6), 335-42. https://doi.org/10.4077/CJP.2014.BAD268
Zhang Y, et al. Alteration of Cardiac ACE2/Mas Expression and Cardiac Remodelling in Rats With Aortic Constriction. Chin J Physiol. 2014 Dec 31;57(6):335-42. PubMed PMID: 25575522.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alteration of cardiac ACE2/Mas expression and cardiac remodelling in rats with aortic constriction. AU - Zhang,Yanling, AU - Li,Bing, AU - Wang,Bingxiangi, AU - Zhang,Jingjun, AU - Wu,Junyan, AU - Morgan,Trefor, PY - 2015/1/11/entrez PY - 2015/1/13/pubmed PY - 2015/8/8/medline SP - 335 EP - 42 JF - The Chinese journal of physiology JO - Chin J Physiol VL - 57 IS - 6 N2 - The recent discovery of the new components of the renin-angiotensin system (RAS) suggests the importance of the maintenance of cardiovascular structure and functions. To assess the role of the angiotensin-converting enzyme 2 (ACE2)-Mas receptor axis in the regulation of cardiac structure and function, the present work investigated the expression of ACE2 and Mas receptor in the heart in the cardiac remodeling that occurs in aortic constricted rats. Partial abdominal aortic ligation was carried out in Sprague-Dawley rats. Angiotensin AT1 receptor blockade and ACE inhibition were achieved by losartan and enalapril treatment, respectively. Results showed that aortic constriction increased left ventricular hypertrophy, fibrosis, mean arterial pressure (MAP), plasma renin activity (PRA) and cardiac ACE levels, but decreased the expression of cardiac ACE2 and Mas receptor. Losartan treatment significantly decreased MAP, left ventricle hypertrophy (LVH), fibrosis, and increased cardiac ACE2 and Mas expression. Enalapril also improved the cardiac parameters with a rise in cardiac ACE2, but did not change the Mas level. In conclusion, aortic constriction results in cardiac hypertrophy, fibrosis and a rise of cardiac ACE expression. Both AT1 receptor blocker and ACE inhibitor play a cardioprotective role in aortic constriction. However, AT1 receptor blocker particularly promotes cardiac ACE2 and Mas receptor levels. ACE inhibitor is associated with the inhibition of ACE and normalization of cardiac ACE2 activity. SN - 0304-4920 UR - https://www.unboundmedicine.com/medline/citation/25575522/Alteration_of_cardiac_ACE2/Mas_expression_and_cardiac_remodelling_in_rats_with_aortic_constriction_ L2 - https://antibodies.cancer.gov/detail/CPTC-ATM-4 DB - PRIME DP - Unbound Medicine ER -