ZnO-CuxO/polypyrrole nanocomposite modified electrode for simultaneous determination of ascorbic acid, dopamine, and uric acid.
Anal Biochem. 2015 Mar 15; 473:53-62.AB

Abstract

Novel zinc oxide (ZnO) nanosheets and copper oxide (CuxO, CuO, and Cu2O) decorated polypyrrole (PPy) nanofibers (ZnO-CuxO-PPy) have been successfully fabricated for the simultaneous determination of ascorbic acid (AA), dopamine (DA), and uric acid (UA). The morphology and structure of ZnO-CuxO-PPy nanocomposites were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and Raman spectroscopy. Compared with the bare glassy carbon electrode (GCE), PPy/GCE, CuxO-PPy/GCE, and ZnO-PPy/GCE, ZnO-CuxO-PPy/GCE exhibits much higher electrocatalytic activities toward the oxidation of AA, DA, and UA with increasing peak currents and decreasing oxidation overpotentials. Cyclic voltammetry (CV) results show that AA, DA, and UA could be detected selectively and sensitively at ZnO-CuxO-PPy/GCE with peak-to-peak separation of 150 and 154 mV for AA-DA and DA-UA, respectively. The calibration curves for AA, DA, and UA were obtained in the ranges of 0.2 to 1.0 mM, 0.1 to 130.0 μM, and 0.5 to 70.0 μM, respectively. The lowest detection limits (signal/noise=3) were 25.0, 0.04, and 0.2 μM for AA, DA, and UA, respectively. With good selectivity and sensitivity, the current method was applied to the determination of DA in injectable medicine and UA in urine samples.

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Authors+Show Affiliations

Ghanbari Kh

Department of Chemistry, School of Science, Alzahra University, Vanak, Tehran 1993891167, Iran. Electronic address: kh_ghanb@yahoo.com.

Hajheidari N

Department of Chemistry, School of Science, Alzahra University, Vanak, Tehran 1993891167, Iran.

MeSH

Ascorbic AcidCopperDopamineElectrochemistryElectrodesInjectionsModels, MolecularMolecular ConformationNanocompositesPolymersPyrrolesTime FactorsUric AcidZinc Oxide

Pub Type(s)

Journal Article

Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25576954

Citation

Ghanbari, Kh, and N Hajheidari. "ZnO-CuxO/polypyrrole Nanocomposite Modified Electrode for Simultaneous Determination of Ascorbic Acid, Dopamine, and Uric Acid." Analytical Biochemistry, vol. 473, 2015, pp. 53-62.

Ghanbari Kh, Hajheidari N. ZnO-CuxO/polypyrrole nanocomposite modified electrode for simultaneous determination of ascorbic acid, dopamine, and uric acid. Anal Biochem. 2015;473:53-62.

Ghanbari, K. h., & Hajheidari, N. (2015). ZnO-CuxO/polypyrrole nanocomposite modified electrode for simultaneous determination of ascorbic acid, dopamine, and uric acid. Analytical Biochemistry, 473, 53-62. https://doi.org/10.1016/j.ab.2014.12.013

Ghanbari Kh, Hajheidari N. ZnO-CuxO/polypyrrole Nanocomposite Modified Electrode for Simultaneous Determination of Ascorbic Acid, Dopamine, and Uric Acid. Anal Biochem. 2015 Mar 15;473:53-62. PubMed PMID: 25576954.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - ZnO-CuxO/polypyrrole nanocomposite modified electrode for simultaneous determination of ascorbic acid, dopamine, and uric acid. AU - Ghanbari,Kh, AU - Hajheidari,N, Y1 - 2015/01/07/ PY - 2014/10/15/received PY - 2014/12/17/revised PY - 2014/12/22/accepted PY - 2015/1/11/entrez PY - 2015/1/13/pubmed PY - 2015/11/18/medline KW - Ascorbic acid KW - Copper oxide KW - Dopamine KW - Polypyrrole nanofiber KW - Uric acid KW - Zinc oxide SP - 53 EP - 62 JF - Analytical biochemistry JO - Anal Biochem VL - 473 N2 - Novel zinc oxide (ZnO) nanosheets and copper oxide (CuxO, CuO, and Cu2O) decorated polypyrrole (PPy) nanofibers (ZnO-CuxO-PPy) have been successfully fabricated for the simultaneous determination of ascorbic acid (AA), dopamine (DA), and uric acid (UA). The morphology and structure of ZnO-CuxO-PPy nanocomposites were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and Raman spectroscopy. Compared with the bare glassy carbon electrode (GCE), PPy/GCE, CuxO-PPy/GCE, and ZnO-PPy/GCE, ZnO-CuxO-PPy/GCE exhibits much higher electrocatalytic activities toward the oxidation of AA, DA, and UA with increasing peak currents and decreasing oxidation overpotentials. Cyclic voltammetry (CV) results show that AA, DA, and UA could be detected selectively and sensitively at ZnO-CuxO-PPy/GCE with peak-to-peak separation of 150 and 154 mV for AA-DA and DA-UA, respectively. The calibration curves for AA, DA, and UA were obtained in the ranges of 0.2 to 1.0 mM, 0.1 to 130.0 μM, and 0.5 to 70.0 μM, respectively. The lowest detection limits (signal/noise=3) were 25.0, 0.04, and 0.2 μM for AA, DA, and UA, respectively. With good selectivity and sensitivity, the current method was applied to the determination of DA in injectable medicine and UA in urine samples. SN - 1096-0309 UR - https://www.unboundmedicine.com/medline/citation/25576954/ZnO_CuxO/polypyrrole_nanocomposite_modified_electrode_for_simultaneous_determination_of_ascorbic_acid_dopamine_and_uric_acid_ DB - PRIME DP - Unbound Medicine ER -

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ZnO-CuxO/polypyrrole nanocomposite modified electrode for simultaneous determination of ascorbic acid, dopamine, and uric acid.Anal Biochem. 2015 Mar 15; 473:53-62.AB