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Vitamin D deficiency is associated with pulmonary dysfunction in cystic fibrosis.
J Cyst Fibros. 2015 Jul; 14(4):497-506.JC

Abstract

BACKGROUND

Vitamin D deficiency is common in CF. Whether vitamin D affects pulmonary function in CF is unknown.

METHODS

Data were abstracted from clinically stable CF patients who had pulmonary function studies and serum 25-hydroxyvitamin D [25(OH)D, ng/ml] levels drawn within 2 months of each other. Findings were adjusted for multiple variables known to affect pulmonary function in CF.

RESULTS

Enrollees totaled 597. Overall mean 25(OH)D level was 29.6±12.8 ng/ml (SD). Serum 25(OH)D levels showed a significant correlation with forced expiratory volume in 1s (FEV1) % predicted (r=0.20, p<0.0001) and forced vital capacity % predicted (r=0.13, p=0.0019). Multivariate analysis revealed that serum 25(OH)D remained an independent predictor of FEV1 % predicted even after controlling for multiple other factors known to affect CF lung function.

CONCLUSIONS

Serum 25(OH)D levels are significantly associated with pulmonary function in CF. Further study is required to determine whether this association is causal.

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Authors+Show Affiliations

Sexauer WP
Pulmonary and Critical Care Division, Department of Medicine, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA. Electronic address: william.sexauer@jefferson.edu.
Hadeh A
Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Drexel University College of Medicine, Philadelphia, PA, USA; Department of Pulmonary and Critical Care Medicine, Cleveland Clinic Florida, Weston, FL, USA.
Ohman-Strickland PA
Rutgers School of Public Health, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Zanni RL
Pulmonary Division, Department of Pediatrics, Monmouth Medical Center, Long Branch, NJ, USA.
Varlotta L
Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA, USA; Section of Pediatric Pulmonology, St. Christopher's Hospital for Children, Philadelphia, PA, USA.
Holsclaw D
Division of Pulmonary, Allergy and Critical Care Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Fiel S
Adult Cystic Fibrosis Center, Morristown Medical Center, Morristown, NJ, USA.
Graff GR
Pulmonary Division, Department of Pediatrics, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA.
Atlas A
Pulmonary Division, Department of Pediatrics, Goryeb Children's Hospital, Morristown Medical Center, Morristown, NJ, USA.
Bisberg D
Barnabas Health, West Orange, NJ, USA.
Hadjiliadis D
Division of Pulmonary, Allergy and Critical Care Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Michel SH
Pulmonary Division, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA.
Mintz D
Pulmonary Division, Department of Pediatrics, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Chakraborty R
Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Drexel University College of Medicine, Philadelphia, PA, USA.
Marra B
Pulmonary Division, Department of Pediatrics, Monmouth Medical Center, Long Branch, NJ, USA.
Lomas P
Adult Cystic Fibrosis Center, Morristown Medical Center, Morristown, NJ, USA.
Ward T
Department of Medicine, Morristown Medical Center, Morristown, NJ, USA.
Sassman M
Cystic Fibrosis Center, St. Christopher's Hospital for Children, Philadelphia, PA, USA.
Imbesi GC
Division of Pulmonary, Allergy and Critical Care Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Kitch DM
Pulmonary Division, Department of Pediatrics, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA.
Mallowe AM
Department of Clinical Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

MeSH

AdolescentAdultChildCystic FibrosisFemaleForced Expiratory VolumeHumansMaleRetrospective StudiesVital CapacityVitamin DVitamin D DeficiencyYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25577127

Citation

Sexauer, William P., et al. "Vitamin D Deficiency Is Associated With Pulmonary Dysfunction in Cystic Fibrosis." Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society, vol. 14, no. 4, 2015, pp. 497-506.
Sexauer WP, Hadeh A, Ohman-Strickland PA, et al. Vitamin D deficiency is associated with pulmonary dysfunction in cystic fibrosis. J Cyst Fibros. 2015;14(4):497-506.
Sexauer, W. P., Hadeh, A., Ohman-Strickland, P. A., Zanni, R. L., Varlotta, L., Holsclaw, D., Fiel, S., Graff, G. R., Atlas, A., Bisberg, D., Hadjiliadis, D., Michel, S. H., Mintz, D., Chakraborty, R., Marra, B., Lomas, P., Ward, T., Sassman, M., Imbesi, G. C., ... Mallowe, A. M. (2015). Vitamin D deficiency is associated with pulmonary dysfunction in cystic fibrosis. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society, 14(4), 497-506. https://doi.org/10.1016/j.jcf.2014.12.006
Sexauer WP, et al. Vitamin D Deficiency Is Associated With Pulmonary Dysfunction in Cystic Fibrosis. J Cyst Fibros. 2015;14(4):497-506. PubMed PMID: 25577127.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D deficiency is associated with pulmonary dysfunction in cystic fibrosis. AU - Sexauer,William P, AU - Hadeh,Anas, AU - Ohman-Strickland,Pamela A, AU - Zanni,Robert L, AU - Varlotta,Laurie, AU - Holsclaw,Douglas, AU - Fiel,Stanley, AU - Graff,Gavin R, AU - Atlas,Arthur, AU - Bisberg,Dorothy, AU - Hadjiliadis,Denis, AU - Michel,Suzanne H, AU - Mintz,Daria, AU - Chakraborty,Rebanta, AU - Marra,Bridget, AU - Lomas,Paula, AU - Ward,Tara, AU - Sassman,Meagen, AU - Imbesi,Giovanna C, AU - Kitch,Diane M, AU - Mallowe,Allison M, Y1 - 2015/01/07/ PY - 2014/09/19/received PY - 2014/12/05/revised PY - 2014/12/11/accepted PY - 2015/1/12/entrez PY - 2015/1/13/pubmed PY - 2016/4/2/medline KW - Cystic fibrosis KW - Lung function KW - Pulmonary function KW - Vitamin D SP - 497 EP - 506 JF - Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society JO - J Cyst Fibros VL - 14 IS - 4 N2 - BACKGROUND: Vitamin D deficiency is common in CF. Whether vitamin D affects pulmonary function in CF is unknown. METHODS: Data were abstracted from clinically stable CF patients who had pulmonary function studies and serum 25-hydroxyvitamin D [25(OH)D, ng/ml] levels drawn within 2 months of each other. Findings were adjusted for multiple variables known to affect pulmonary function in CF. RESULTS: Enrollees totaled 597. Overall mean 25(OH)D level was 29.6±12.8 ng/ml (SD). Serum 25(OH)D levels showed a significant correlation with forced expiratory volume in 1s (FEV1) % predicted (r=0.20, p<0.0001) and forced vital capacity % predicted (r=0.13, p=0.0019). Multivariate analysis revealed that serum 25(OH)D remained an independent predictor of FEV1 % predicted even after controlling for multiple other factors known to affect CF lung function. CONCLUSIONS: Serum 25(OH)D levels are significantly associated with pulmonary function in CF. Further study is required to determine whether this association is causal. SN - 1873-5010 UR - https://www.unboundmedicine.com/medline/citation/25577127/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S1569-1993(14)00303-8 DB - PRIME DP - Unbound Medicine ER -