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Efficacy of controlled-release capsules containing monensin for the prevention of subclinical ketosis in pasture-fed dairy cows.
N Z Vet J. 2015 Sep; 63(5):249-53.NZ

Abstract

AIMS

To determine the effectiveness of intra-rumenal controlled release capsules (CRC) containing 32 g of monensin administered pre-calving to reduce the cumulative incidence of subclinical ketosis (SCK) in mainly pasture-fed dairy cows.

METHODS

Cows (n=837) due to calve in the first 6 weeks of the spring calving period were enrolled from four commercial herds in the Waikato region of New Zealand in a blinded, randomised, negative-controlled field trial. Three weeks before the start of the calving period cows were randomly allocated to receive either no treatment (control) or a single CRC containing monensin and then blood sampled on two occasions, 7 days apart within 12 days following calving for measurement of concentrations of beta hydroxybutyrate (BHBA) in blood. Cows were diagnosed with SCK if the concentration of BHBA in blood in either of these samples was ≥1.2 mmol/L.

RESULTS

Fewer treated cows were diagnosed with SCK within 12 days post-calving than control cows (144/340 (42.4%) vs. 192/336 (57.1%); p<0.001). There was no interaction between treatment group and age, breed or herd of origin. From the final multivariable model it was estimated that treatment with CRC containing monensin reduced the absolute cumulative incidence of SCK by 17.9 (95% CI=9.2-25.8)% compared to no treatment.

CONCLUSIONS

Treatment with a CRC containing monensin>10 days prior to calving reduced the cumulative incidence of SCK of pasture-based dairy cows in commercial dairy herds within 12 days post-calving.

CLINICAL RELEVANCE

Administration pre-calving of an intra-rumenal bolus containing monensin can be considered as one of a range of management options for the control of SCK in early lactation.

Authors+Show Affiliations

a Cognosco , Anexa Animal Health , PO Box 21, Morrinsville , New Zealand.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25578365

Citation

Compton, C W R., et al. "Efficacy of Controlled-release Capsules Containing Monensin for the Prevention of Subclinical Ketosis in Pasture-fed Dairy Cows." New Zealand Veterinary Journal, vol. 63, no. 5, 2015, pp. 249-53.
Compton CW, Young L, McDougall S. Efficacy of controlled-release capsules containing monensin for the prevention of subclinical ketosis in pasture-fed dairy cows. N Z Vet J. 2015;63(5):249-53.
Compton, C. W., Young, L., & McDougall, S. (2015). Efficacy of controlled-release capsules containing monensin for the prevention of subclinical ketosis in pasture-fed dairy cows. New Zealand Veterinary Journal, 63(5), 249-53. https://doi.org/10.1080/00480169.2014.999842
Compton CW, Young L, McDougall S. Efficacy of Controlled-release Capsules Containing Monensin for the Prevention of Subclinical Ketosis in Pasture-fed Dairy Cows. N Z Vet J. 2015;63(5):249-53. PubMed PMID: 25578365.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of controlled-release capsules containing monensin for the prevention of subclinical ketosis in pasture-fed dairy cows. AU - Compton,C W R, AU - Young,L, AU - McDougall,S, Y1 - 2015/06/18/ PY - 2015/1/13/entrez PY - 2015/1/13/pubmed PY - 2015/9/26/medline KW - Randomised KW - beta hydroxybutyrate KW - clinical trial KW - dairy cow KW - monensin KW - pasture KW - subclinical ketosis SP - 249 EP - 53 JF - New Zealand veterinary journal JO - N Z Vet J VL - 63 IS - 5 N2 - AIMS: To determine the effectiveness of intra-rumenal controlled release capsules (CRC) containing 32 g of monensin administered pre-calving to reduce the cumulative incidence of subclinical ketosis (SCK) in mainly pasture-fed dairy cows. METHODS: Cows (n=837) due to calve in the first 6 weeks of the spring calving period were enrolled from four commercial herds in the Waikato region of New Zealand in a blinded, randomised, negative-controlled field trial. Three weeks before the start of the calving period cows were randomly allocated to receive either no treatment (control) or a single CRC containing monensin and then blood sampled on two occasions, 7 days apart within 12 days following calving for measurement of concentrations of beta hydroxybutyrate (BHBA) in blood. Cows were diagnosed with SCK if the concentration of BHBA in blood in either of these samples was ≥1.2 mmol/L. RESULTS: Fewer treated cows were diagnosed with SCK within 12 days post-calving than control cows (144/340 (42.4%) vs. 192/336 (57.1%); p<0.001). There was no interaction between treatment group and age, breed or herd of origin. From the final multivariable model it was estimated that treatment with CRC containing monensin reduced the absolute cumulative incidence of SCK by 17.9 (95% CI=9.2-25.8)% compared to no treatment. CONCLUSIONS: Treatment with a CRC containing monensin>10 days prior to calving reduced the cumulative incidence of SCK of pasture-based dairy cows in commercial dairy herds within 12 days post-calving. CLINICAL RELEVANCE: Administration pre-calving of an intra-rumenal bolus containing monensin can be considered as one of a range of management options for the control of SCK in early lactation. SN - 0048-0169 UR - https://www.unboundmedicine.com/medline/citation/25578365/Efficacy_of_controlled_release_capsules_containing_monensin_for_the_prevention_of_subclinical_ketosis_in_pasture_fed_dairy_cows_ L2 - http://www.tandfonline.com/doi/full/10.1080/00480169.2014.999842 DB - PRIME DP - Unbound Medicine ER -