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Usefulness of antibodies and minor salivary gland biopsy in the study of sicca syndrome in daily clinical practice.
Reumatol Clin. 2015 May-Jun; 11(3):156-60.RC

Abstract

OBJECTIVES

To assess the association between histologic findings in the minor salivary gland biopsy (MSGB) and anti La (La/SS-B)y antiRo antibodies (Ro/SS-A), antinuclear antibodies (ANA) and Rheumatoid Factor (RF),and compare the value of the latter as diagnostic tests with MSGB, considered as the gold standard.

MATERIAL AND METHOD

Patients with suspected Primary Sjögren Syndrome (PSS) referred for MSGB were included. Antibody measurements were performed. Grade III and IV biopsy results were considered positive.

RESULTS

Two hundred and eighteen (218) patients were included, 95% females, with a median age of 54 years and 12 months median duration of sicca symptoms. 36 of the biopsies were positive. 33% of patients had positive anti Ro/SS-A anti La/SS-B antibodies, 62% had positive ANA, and 31% positive RF. A statistically significant association was found between MSGB and anti Ro/SS-A anti La/SS-B, ANA and RF. ANA were the most sensitive antibodies (84%. 95% CI: 75- 92), and the most specific were: Anti Ro/ SS-A and/or anti La/ SS-B (78%. 95% CI: 71-85) and RF (78%. 95% CI: 69-87).

CONCLUSION

On PSS clinical suspicion, anti Ro/ SS-A y anti La/ SS-B antibodies have a great value to achieve the diagnosis, with MSGB useful for diagnosis of seronegative patients. The results also suggest the importance of ANA and RF for PSS classification.

Authors+Show Affiliations

Servicio de Reumatología, Hospital General de Agudos Bernardino Rivadavia, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina. Electronic address: lidasantiagor@yahoo.com.ar.Servicio de Reumatología, Hospital General de Agudos Bernardino Rivadavia, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.Servicio de Reumatología, Hospital General de Agudos Bernardino Rivadavia, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.Servicio de Reumatología, Hospital General de Agudos Bernardino Rivadavia, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.Cátedra de Anatomía Patológica, Facultad de Medicina, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.Servicio de Reumatología, Hospital General de Agudos Bernardino Rivadavia, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

25579246

Citation

Santiago, Maria Lida, et al. "Usefulness of Antibodies and Minor Salivary Gland Biopsy in the Study of Sicca Syndrome in Daily Clinical Practice." Reumatologia Clinica, vol. 11, no. 3, 2015, pp. 156-60.
Santiago ML, Seisdedos MR, Garcia Salinas RN, et al. Usefulness of antibodies and minor salivary gland biopsy in the study of sicca syndrome in daily clinical practice. Reumatol Clin. 2015;11(3):156-60.
Santiago, M. L., Seisdedos, M. R., Garcia Salinas, R. N., Catalán Pellet, A., Villalón, L., & Secco, A. (2015). Usefulness of antibodies and minor salivary gland biopsy in the study of sicca syndrome in daily clinical practice. Reumatologia Clinica, 11(3), 156-60. https://doi.org/10.1016/j.reuma.2014.06.004
Santiago ML, et al. Usefulness of Antibodies and Minor Salivary Gland Biopsy in the Study of Sicca Syndrome in Daily Clinical Practice. Reumatol Clin. 2015 May-Jun;11(3):156-60. PubMed PMID: 25579246.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Usefulness of antibodies and minor salivary gland biopsy in the study of sicca syndrome in daily clinical practice. AU - Santiago,Maria Lida, AU - Seisdedos,Maria Renata, AU - Garcia Salinas,Rodrigo Nicolás, AU - Catalán Pellet,Antonio, AU - Villalón,Liliana, AU - Secco,Anastasia, Y1 - 2015/01/09/ PY - 2014/02/12/received PY - 2014/06/02/revised PY - 2014/06/06/accepted PY - 2015/1/13/entrez PY - 2015/1/13/pubmed PY - 2016/12/15/medline KW - Anti La/SS-B KW - Anti Ro/SS-A KW - Biopsia de glándula salival KW - Complejo sicca KW - Salivary gland biopsy KW - Sicca complex KW - Sjögren SP - 156 EP - 60 JF - Reumatologia clinica JO - Reumatol Clin VL - 11 IS - 3 N2 - OBJECTIVES: To assess the association between histologic findings in the minor salivary gland biopsy (MSGB) and anti La (La/SS-B)y antiRo antibodies (Ro/SS-A), antinuclear antibodies (ANA) and Rheumatoid Factor (RF),and compare the value of the latter as diagnostic tests with MSGB, considered as the gold standard. MATERIAL AND METHOD: Patients with suspected Primary Sjögren Syndrome (PSS) referred for MSGB were included. Antibody measurements were performed. Grade III and IV biopsy results were considered positive. RESULTS: Two hundred and eighteen (218) patients were included, 95% females, with a median age of 54 years and 12 months median duration of sicca symptoms. 36 of the biopsies were positive. 33% of patients had positive anti Ro/SS-A anti La/SS-B antibodies, 62% had positive ANA, and 31% positive RF. A statistically significant association was found between MSGB and anti Ro/SS-A anti La/SS-B, ANA and RF. ANA were the most sensitive antibodies (84%. 95% CI: 75- 92), and the most specific were: Anti Ro/ SS-A and/or anti La/ SS-B (78%. 95% CI: 71-85) and RF (78%. 95% CI: 69-87). CONCLUSION: On PSS clinical suspicion, anti Ro/ SS-A y anti La/ SS-B antibodies have a great value to achieve the diagnosis, with MSGB useful for diagnosis of seronegative patients. The results also suggest the importance of ANA and RF for PSS classification. SN - 1885-1398 UR - https://www.unboundmedicine.com/medline/citation/25579246/Usefulness_of_antibodies_and_minor_salivary_gland_biopsy_in_the_study_of_sicca_syndrome_in_daily_clinical_practice_ L2 - http://www.elsevier.es/en/linksolver/pdf/pii/S1699-258X(14)00131-4 DB - PRIME DP - Unbound Medicine ER -