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Myocardial mechanics in a rat model with banding and debanding of the ascending aorta.
J Cardiovasc Ultrasound 2014; 22(4):189-95JC

Abstract

BACKGROUND

Aortic banding and debanding models have provided useful information on the development and regression of left ventricular hypertrophy (LVH). In this animal study, we aimed to evaluate left ventricular (LV) deformation related to the development and regression of LVH.

METHODS

Minimally invasive ascending aorta banding was performed in rats (10 Sprague Dawley rats, 7 weeks). Ten rats underwent a sham operation. Thirty-five days later, the band was removed. Echocardiographic and histopathologic analysis was assessed at pre-banding, 35 days of banding and 14 days of debanding.

RESULTS

Banding of the ascending aorta created an expected increase in the aortic velocity and gradient, which normalized with the debanding procedure. Pressure overload resulted in a robust hypertrophic response as assessed by gross and microscopic histology, transthoracic echocardiography [heart weight/tibia length (g/m); 21.0 ± 0.8 vs. 33.2 ± 2.0 vs. 26.6 ± 2.8, p < 0.001]. The circumferential (CS) and radial strains were not different between the groups. However, there were significant differences in the degree of fibrosis according to the banding status (fibrosis; 0.10 ± 0.20% vs. 5.26 ± 3.12% vs. 4.03 ± 3.93%, p = 0.003), and global CS showed a significant correlation with the degree of myocardial fibrosis in this animal model (r = 0.688, p = 0.028).

CONCLUSION

In this animal study, simulating a severe LV pressure overload state, a significant increase in the LV mass index did not result in a significant reduction in the LV mechanical parameters. The degree of LV fibrosis, which developed with pressure overload, was significantly related to the magnitude of left ventricular mechanics.

Authors+Show Affiliations

Division of Cardiology, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.Division of Cardiology, St. Paul's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.Department of Thoracic and Cardiovascular Surgery, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.The University of Debrecen Medical and Health Science Center, Debrecen, Hungary.Clinical Research Institute, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.Department of Pathology, Hwasun Hospital, Chonnam National University Medical School, Gwangju, Korea.Clinical Research Institute, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.Division of Cardiology, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.Division of Cardiology, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.Division of Cardiology, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.Division of Cardiology, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25580193

Citation

Cho, Jung Sun, et al. "Myocardial Mechanics in a Rat Model With Banding and Debanding of the Ascending Aorta." Journal of Cardiovascular Ultrasound, vol. 22, no. 4, 2014, pp. 189-95.
Cho JS, Cho EJ, Lee J, et al. Myocardial mechanics in a rat model with banding and debanding of the ascending aorta. J Cardiovasc Ultrasound. 2014;22(4):189-95.
Cho, J. S., Cho, E. J., Lee, J., Choi, H. D., Park, K. C., Lee, K. H., ... Kim, C. J. (2014). Myocardial mechanics in a rat model with banding and debanding of the ascending aorta. Journal of Cardiovascular Ultrasound, 22(4), pp. 189-95. doi:10.4250/jcu.2014.22.4.189.
Cho JS, et al. Myocardial Mechanics in a Rat Model With Banding and Debanding of the Ascending Aorta. J Cardiovasc Ultrasound. 2014;22(4):189-95. PubMed PMID: 25580193.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Myocardial mechanics in a rat model with banding and debanding of the ascending aorta. AU - Cho,Jung Sun, AU - Cho,Eun Joo, AU - Lee,Jongho, AU - Choi,Hyun-Duck, AU - Park,Ki Cheol, AU - Lee,Kyung-Hwa, AU - Yang,Keum-Jin, AU - Park,Mahn-Won, AU - Park,Gyung-Min, AU - Her,Sung-Ho, AU - Kim,Chan Joon, Y1 - 2014/12/26/ PY - 2014/08/07/received PY - 2014/12/08/revised PY - 2014/12/08/accepted PY - 2015/1/13/entrez PY - 2015/1/13/pubmed PY - 2015/1/13/medline KW - Aortic banding KW - Debanding KW - Left ventricular hypertrophy SP - 189 EP - 95 JF - Journal of cardiovascular ultrasound JO - J Cardiovasc Ultrasound VL - 22 IS - 4 N2 - BACKGROUND: Aortic banding and debanding models have provided useful information on the development and regression of left ventricular hypertrophy (LVH). In this animal study, we aimed to evaluate left ventricular (LV) deformation related to the development and regression of LVH. METHODS: Minimally invasive ascending aorta banding was performed in rats (10 Sprague Dawley rats, 7 weeks). Ten rats underwent a sham operation. Thirty-five days later, the band was removed. Echocardiographic and histopathologic analysis was assessed at pre-banding, 35 days of banding and 14 days of debanding. RESULTS: Banding of the ascending aorta created an expected increase in the aortic velocity and gradient, which normalized with the debanding procedure. Pressure overload resulted in a robust hypertrophic response as assessed by gross and microscopic histology, transthoracic echocardiography [heart weight/tibia length (g/m); 21.0 ± 0.8 vs. 33.2 ± 2.0 vs. 26.6 ± 2.8, p < 0.001]. The circumferential (CS) and radial strains were not different between the groups. However, there were significant differences in the degree of fibrosis according to the banding status (fibrosis; 0.10 ± 0.20% vs. 5.26 ± 3.12% vs. 4.03 ± 3.93%, p = 0.003), and global CS showed a significant correlation with the degree of myocardial fibrosis in this animal model (r = 0.688, p = 0.028). CONCLUSION: In this animal study, simulating a severe LV pressure overload state, a significant increase in the LV mass index did not result in a significant reduction in the LV mechanical parameters. The degree of LV fibrosis, which developed with pressure overload, was significantly related to the magnitude of left ventricular mechanics. SN - 1975-4612 UR - https://www.unboundmedicine.com/medline/citation/25580193/Myocardial_mechanics_in_a_rat_model_with_banding_and_debanding_of_the_ascending_aorta_ L2 - https://e-jcvi.org/DOIx.php?id=10.4250/jcu.2014.22.4.189 DB - PRIME DP - Unbound Medicine ER -