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Nanogels for delivery, imaging and therapy.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2015 Jul-Aug; 7(4):509-33.WI

Abstract

Nanogels are hydrogels having size in nanoregime, which is composed of cross-linked polymer networks. The advantages of nanogels include stimuli-responsive nature, easy drug loading, and higher drug-loading capacity, physical stability, versatility in design, stability of entrapped drug, and controlled release of the anti-inflammatory, antimicrobial, protein, peptide and anticancer drugs. Stimuli-responsive nature of nanogel is of particular importance in anticancer and anti-inflammatory drug delivery, as cancer and inflammation are associated with acidic pH, heat generation, and change in ionic content. Nanogels composed of muco-adhesive polymers provide prolonged residence time and increase the ocular availability of loaded drugs. By forming suitably sized complex with proteins or by acting as artificial chaperones, they thus help to keep the proteins and enzymes in proper confirmation necessary for exerting biological activity; nanogels can increase the stability and activity of protein/peptide drugs. Better drug penetrations achieved by prolonged contact with skin contribute much in transdermal drug delivery. When it comes to cancer drug delivery, the presence of multiple interactive functional groups in nanogels different targeting agents can be conjugated for delivery of the selective drugs. This review focuses on applications of nanogels in cancer drug delivery and imaging, anti-inflammatory, anti-psoriatic, transdermal, ocular and protein/peptide drug delivery and therapy.

Authors+Show Affiliations

Amrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Kochi, India.Amrita School of Pharmacy, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Kochi, India.Amrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Kochi, India.Amrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Kochi, India.Amrita School of Pharmacy, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Kochi, India.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25581024

Citation

Sivaram, Amal J., et al. "Nanogels for Delivery, Imaging and Therapy." Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology, vol. 7, no. 4, 2015, pp. 509-33.
Sivaram AJ, Rajitha P, Maya S, et al. Nanogels for delivery, imaging and therapy. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2015;7(4):509-33.
Sivaram, A. J., Rajitha, P., Maya, S., Jayakumar, R., & Sabitha, M. (2015). Nanogels for delivery, imaging and therapy. Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology, 7(4), 509-33. https://doi.org/10.1002/wnan.1328
Sivaram AJ, et al. Nanogels for Delivery, Imaging and Therapy. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2015 Jul-Aug;7(4):509-33. PubMed PMID: 25581024.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nanogels for delivery, imaging and therapy. AU - Sivaram,Amal J, AU - Rajitha,P, AU - Maya,S, AU - Jayakumar,R, AU - Sabitha,M, Y1 - 2015/01/08/ PY - 2014/09/11/received PY - 2014/10/27/revised PY - 2014/11/08/accepted PY - 2015/1/13/entrez PY - 2015/1/13/pubmed PY - 2016/3/26/medline SP - 509 EP - 33 JF - Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology JO - Wiley Interdiscip Rev Nanomed Nanobiotechnol VL - 7 IS - 4 N2 - Nanogels are hydrogels having size in nanoregime, which is composed of cross-linked polymer networks. The advantages of nanogels include stimuli-responsive nature, easy drug loading, and higher drug-loading capacity, physical stability, versatility in design, stability of entrapped drug, and controlled release of the anti-inflammatory, antimicrobial, protein, peptide and anticancer drugs. Stimuli-responsive nature of nanogel is of particular importance in anticancer and anti-inflammatory drug delivery, as cancer and inflammation are associated with acidic pH, heat generation, and change in ionic content. Nanogels composed of muco-adhesive polymers provide prolonged residence time and increase the ocular availability of loaded drugs. By forming suitably sized complex with proteins or by acting as artificial chaperones, they thus help to keep the proteins and enzymes in proper confirmation necessary for exerting biological activity; nanogels can increase the stability and activity of protein/peptide drugs. Better drug penetrations achieved by prolonged contact with skin contribute much in transdermal drug delivery. When it comes to cancer drug delivery, the presence of multiple interactive functional groups in nanogels different targeting agents can be conjugated for delivery of the selective drugs. This review focuses on applications of nanogels in cancer drug delivery and imaging, anti-inflammatory, anti-psoriatic, transdermal, ocular and protein/peptide drug delivery and therapy. SN - 1939-0041 UR - https://www.unboundmedicine.com/medline/citation/25581024/Nanogels_for_delivery_imaging_and_therapy_ L2 - https://doi.org/10.1002/wnan.1328 DB - PRIME DP - Unbound Medicine ER -