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Meat subtypes and their association with colorectal cancer: Systematic review and meta-analysis.
Int J Cancer 2016; 138(2):293-302IJ

Abstract

Associations between specific red meat subtypes and risk of colorectal cancer (CRC) have been investigated in a number of epidemiological studies. However, no publication to date has summarised the overall epidemiological evidence. We conducted a systematic review and meta-analysis of prospective studies (cohort, nested case-control or case-cohort studies), which reported relative risk (RR) estimates and 95% confidence intervals (CI) for the association between intake of meat subtypes with colorectal, colon or rectal cancer or colorectal adenoma risk. PubMed and ISI Web of Science were searched up until August 1, 2014. Nineteen studies examined meat subtypes (5 beef, 5 pork, 2 lamb, 1 veal and 19 poultry) and associations with colorectal, colon or rectal cancer risk and 4 studies examined associations with adenoma risk (1 beef and 4 poultry). Comparing highest versus lowest intake, beef consumption was associated with an increased risk of CRC (RR = 1.11, 95% CI = 1.01 to 1.22) and colon cancer (RR = 1.24, 95% CI = 1.07 to 1.44), but no association was found with rectal cancer (RR = 0.95, 95% CI = 0.78 to 1.16). Higher consumption of lamb was also associated with increased risk of CRC (RR = 1.24, 95% CI = 1.08 to 1.44). No association was observed for pork (RR = 1.07, 95% CI = 0.90 to 1.27), but some between study heterogeneity was observed. No association was observed for poultry consumption and risk of colorectal adenomas or cancer. This meta-analysis suggests that red meat subtypes differ in their association with CRC and its sub sites. Further analysis of data from prospective cohort studies is warranted, especially regarding the role of pork.

Authors+Show Affiliations

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany. German Cancer Consortium (DKTK), Heidelberg, Germany.Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

25583132

Citation

Carr, Prudence R., et al. "Meat Subtypes and Their Association With Colorectal Cancer: Systematic Review and Meta-analysis." International Journal of Cancer, vol. 138, no. 2, 2016, pp. 293-302.
Carr PR, Walter V, Brenner H, et al. Meat subtypes and their association with colorectal cancer: Systematic review and meta-analysis. Int J Cancer. 2016;138(2):293-302.
Carr, P. R., Walter, V., Brenner, H., & Hoffmeister, M. (2016). Meat subtypes and their association with colorectal cancer: Systematic review and meta-analysis. International Journal of Cancer, 138(2), pp. 293-302. doi:10.1002/ijc.29423.
Carr PR, et al. Meat Subtypes and Their Association With Colorectal Cancer: Systematic Review and Meta-analysis. Int J Cancer. 2016 Jan 15;138(2):293-302. PubMed PMID: 25583132.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meat subtypes and their association with colorectal cancer: Systematic review and meta-analysis. AU - Carr,Prudence R, AU - Walter,Viola, AU - Brenner,Hermann, AU - Hoffmeister,Michael, Y1 - 2015/02/24/ PY - 2014/10/31/received PY - 2014/12/19/accepted PY - 2015/1/14/entrez PY - 2015/1/15/pubmed PY - 2016/5/28/medline KW - colorectal cancer KW - meat subtypes KW - meta-analysis KW - poultry KW - red meat SP - 293 EP - 302 JF - International journal of cancer JO - Int. J. Cancer VL - 138 IS - 2 N2 - Associations between specific red meat subtypes and risk of colorectal cancer (CRC) have been investigated in a number of epidemiological studies. However, no publication to date has summarised the overall epidemiological evidence. We conducted a systematic review and meta-analysis of prospective studies (cohort, nested case-control or case-cohort studies), which reported relative risk (RR) estimates and 95% confidence intervals (CI) for the association between intake of meat subtypes with colorectal, colon or rectal cancer or colorectal adenoma risk. PubMed and ISI Web of Science were searched up until August 1, 2014. Nineteen studies examined meat subtypes (5 beef, 5 pork, 2 lamb, 1 veal and 19 poultry) and associations with colorectal, colon or rectal cancer risk and 4 studies examined associations with adenoma risk (1 beef and 4 poultry). Comparing highest versus lowest intake, beef consumption was associated with an increased risk of CRC (RR = 1.11, 95% CI = 1.01 to 1.22) and colon cancer (RR = 1.24, 95% CI = 1.07 to 1.44), but no association was found with rectal cancer (RR = 0.95, 95% CI = 0.78 to 1.16). Higher consumption of lamb was also associated with increased risk of CRC (RR = 1.24, 95% CI = 1.08 to 1.44). No association was observed for pork (RR = 1.07, 95% CI = 0.90 to 1.27), but some between study heterogeneity was observed. No association was observed for poultry consumption and risk of colorectal adenomas or cancer. This meta-analysis suggests that red meat subtypes differ in their association with CRC and its sub sites. Further analysis of data from prospective cohort studies is warranted, especially regarding the role of pork. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/25583132/Meat_subtypes_and_their_association_with_colorectal_cancer:_Systematic_review_and_meta_analysis_ L2 - https://doi.org/10.1002/ijc.29423 DB - PRIME DP - Unbound Medicine ER -