Tags

Type your tag names separated by a space and hit enter

Predictors of treatment response in young people at ultra-high risk for psychosis who received long-chain omega-3 fatty acids.
Transl Psychiatry. 2015 Jan 13; 5:e495.TP

Abstract

Previous efforts in the prospective evaluation of individuals who experience attenuated psychotic symptoms have attempted to isolate mechanisms underlying the onset of full-threshold psychotic illness. In contrast, there has been little research investigating specific predictors of positive outcomes. In this study, we sought to determine biological and clinical factors associated with treatment response, here indexed by functional improvement in a pre-post examination of a 12-week randomized controlled intervention in individuals at ultra-high risk (UHR) for psychosis. Participants received either long-chain omega-3 (ω-3) polyunsaturated fatty acids (PUFAs) or placebo. To allow the determination of factors specifically relevant to each intervention, and to be able to contrast them, both treatment groups were investigated in parallel. Univariate linear regression analysis indicated that higher levels of erythrocyte membrane α-linolenic acid (ALA; the parent fatty acid of the ω-3 family) and more severe negative symptoms at baseline predicted subsequent functional improvement in the treatment group, whereas less severe positive symptoms and lower functioning at baseline were predictive in the placebo group. A multivariate machine learning analysis, known as Gaussian Process Classification (GPC), confirmed that baseline fatty acids predicted response to treatment in the ω-3 PUFA group with high levels of sensitivity, specificity and accuracy. In addition, GPC revealed that baseline fatty acids were predictive in the placebo group. In conclusion, our investigation indicates that UHR patients with higher levels of ALA may specifically benefit from ω-3 PUFA supplementation. In addition, multivariate machine learning analysis suggests that fatty acids could potentially be used to inform prognostic evaluations and treatment decisions at the level of the individual. Notably, multiple statistical analyses were conducted in a relatively small sample, limiting the conclusions that can be drawn from what we believe to be a first-of-its-kind study. Additional studies with larger samples are therefore needed to evaluate the generalizability of these findings.

Authors+Show Affiliations

Orygen, The National Centre of Excellence in Youth Mental Health, The University of Melbourne Centre for Youth Mental Health and Melbourne Health, Parkville, VIC, Australia.Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.Orygen, The National Centre of Excellence in Youth Mental Health, The University of Melbourne Centre for Youth Mental Health and Melbourne Health, Parkville, VIC, Australia.Department of Psychiatry, Chonnam National University Medical School, Gwangju, Republic of Korea.Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.School of Medicine, Deakin University, Geelong, VIC, Australia.Orygen, The National Centre of Excellence in Youth Mental Health, The University of Melbourne Centre for Youth Mental Health and Melbourne Health, Parkville, VIC, Australia.Orygen, The National Centre of Excellence in Youth Mental Health, The University of Melbourne Centre for Youth Mental Health and Melbourne Health, Parkville, VIC, Australia.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25585167

Citation

Amminger, G P., et al. "Predictors of Treatment Response in Young People at Ultra-high Risk for Psychosis Who Received Long-chain Omega-3 Fatty Acids." Translational Psychiatry, vol. 5, 2015, pp. e495.
Amminger GP, Mechelli A, Rice S, et al. Predictors of treatment response in young people at ultra-high risk for psychosis who received long-chain omega-3 fatty acids. Transl Psychiatry. 2015;5:e495.
Amminger, G. P., Mechelli, A., Rice, S., Kim, S. W., Klier, C. M., McNamara, R. K., Berk, M., McGorry, P. D., & Schäfer, M. R. (2015). Predictors of treatment response in young people at ultra-high risk for psychosis who received long-chain omega-3 fatty acids. Translational Psychiatry, 5, e495. https://doi.org/10.1038/tp.2014.134
Amminger GP, et al. Predictors of Treatment Response in Young People at Ultra-high Risk for Psychosis Who Received Long-chain Omega-3 Fatty Acids. Transl Psychiatry. 2015 Jan 13;5:e495. PubMed PMID: 25585167.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predictors of treatment response in young people at ultra-high risk for psychosis who received long-chain omega-3 fatty acids. AU - Amminger,G P, AU - Mechelli,A, AU - Rice,S, AU - Kim,S-W, AU - Klier,C M, AU - McNamara,R K, AU - Berk,M, AU - McGorry,P D, AU - Schäfer,M R, Y1 - 2015/01/13/ PY - 2014/01/02/received PY - 2014/10/19/revised PY - 2014/10/26/accepted PY - 2015/1/14/entrez PY - 2015/1/15/pubmed PY - 2015/9/10/medline SP - e495 EP - e495 JF - Translational psychiatry JO - Transl Psychiatry VL - 5 N2 - Previous efforts in the prospective evaluation of individuals who experience attenuated psychotic symptoms have attempted to isolate mechanisms underlying the onset of full-threshold psychotic illness. In contrast, there has been little research investigating specific predictors of positive outcomes. In this study, we sought to determine biological and clinical factors associated with treatment response, here indexed by functional improvement in a pre-post examination of a 12-week randomized controlled intervention in individuals at ultra-high risk (UHR) for psychosis. Participants received either long-chain omega-3 (ω-3) polyunsaturated fatty acids (PUFAs) or placebo. To allow the determination of factors specifically relevant to each intervention, and to be able to contrast them, both treatment groups were investigated in parallel. Univariate linear regression analysis indicated that higher levels of erythrocyte membrane α-linolenic acid (ALA; the parent fatty acid of the ω-3 family) and more severe negative symptoms at baseline predicted subsequent functional improvement in the treatment group, whereas less severe positive symptoms and lower functioning at baseline were predictive in the placebo group. A multivariate machine learning analysis, known as Gaussian Process Classification (GPC), confirmed that baseline fatty acids predicted response to treatment in the ω-3 PUFA group with high levels of sensitivity, specificity and accuracy. In addition, GPC revealed that baseline fatty acids were predictive in the placebo group. In conclusion, our investigation indicates that UHR patients with higher levels of ALA may specifically benefit from ω-3 PUFA supplementation. In addition, multivariate machine learning analysis suggests that fatty acids could potentially be used to inform prognostic evaluations and treatment decisions at the level of the individual. Notably, multiple statistical analyses were conducted in a relatively small sample, limiting the conclusions that can be drawn from what we believe to be a first-of-its-kind study. Additional studies with larger samples are therefore needed to evaluate the generalizability of these findings. SN - 2158-3188 UR - https://www.unboundmedicine.com/medline/citation/25585167/Predictors_of_treatment_response_in_young_people_at_ultra_high_risk_for_psychosis_who_received_long_chain_omega_3_fatty_acids_ L2 - https://doi.org/10.1038/tp.2014.134 DB - PRIME DP - Unbound Medicine ER -