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Early hyaluronate injection improves quality of life but not neural recovery in unilateral vocal fold paralysis: an open-label randomized controlled study.
Restor Neurol Neurosci. 2015; 33(2):121-30.RN

Abstract

PURPOSE

To investigate the neurologic and functional effect of intracordal hyaluronate injections in acute unilateral vocal fold paralysis (UVFP) in a randomized controlled trial.

METHODS

In this open-label, randomized controlled study, 29 patients with UVFP were recruited within 6 months of their first outpatient visit and were randomized to receive either single hyaluronate injection (HI group) or conservative management (CM group). Quantitative laryngeal electromyography, videolaryngostroboscopy, UVFP-related quality of life (Voice Outcomes Survey, VOS), laboratory voice analysis, and health-related quality of life (SF-36) were evaluated at baseline, and at 1, 3 and 6 months post-injection in the HI group, and at baseline and 6 months in the CM group.

RESULTS

Improvements in most quality of life domains and other assessments were comparable between the HI and CM groups; however, the HI group had a greater improvement in the mental health domain of quality of life at the end of follow-up.

CONCLUSIONS

Early hyaluronate injection cannot improve nerve regeneration but can result in long-lasting improvements in patients' psychosocial well-being, thus highlighting the importance of early intervention for patients with UVFP.

Authors+Show Affiliations

Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan School of Medicine, Chang Gung University, Taoyuan, Taiwan Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan.School of Medicine, Chang Gung University, Taoyuan, Taiwan Department of Otolaryngology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.School of Medicine, Chang Gung University, Taoyuan, Taiwan Department of Otolaryngology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.School of Medicine, Chang Gung University, Taoyuan, Taiwan Department of Otolaryngology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan School of Medicine, Chang Gung University, Taoyuan, Taiwan Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

25588457

Citation

Pei, Yu-Cheng, et al. "Early Hyaluronate Injection Improves Quality of Life but Not Neural Recovery in Unilateral Vocal Fold Paralysis: an Open-label Randomized Controlled Study." Restorative Neurology and Neuroscience, vol. 33, no. 2, 2015, pp. 121-30.
Pei YC, Fang TJ, Hsin LJ, et al. Early hyaluronate injection improves quality of life but not neural recovery in unilateral vocal fold paralysis: an open-label randomized controlled study. Restor Neurol Neurosci. 2015;33(2):121-30.
Pei, Y. C., Fang, T. J., Hsin, L. J., Li, H. Y., & Wong, A. M. (2015). Early hyaluronate injection improves quality of life but not neural recovery in unilateral vocal fold paralysis: an open-label randomized controlled study. Restorative Neurology and Neuroscience, 33(2), 121-30. https://doi.org/10.3233/RNN-140439
Pei YC, et al. Early Hyaluronate Injection Improves Quality of Life but Not Neural Recovery in Unilateral Vocal Fold Paralysis: an Open-label Randomized Controlled Study. Restor Neurol Neurosci. 2015;33(2):121-30. PubMed PMID: 25588457.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early hyaluronate injection improves quality of life but not neural recovery in unilateral vocal fold paralysis: an open-label randomized controlled study. AU - Pei,Yu-Cheng, AU - Fang,Tuan-Jen, AU - Hsin,Li-Jen, AU - Li,Hsueh-Yu, AU - Wong,Alice Mk, PY - 2015/1/16/entrez PY - 2015/1/16/pubmed PY - 2015/12/15/medline KW - Unilateral vocal fold paralysis KW - glottal gap KW - hyaluronate KW - injection laryngoplasty KW - laryngeal electromyography KW - quality of life SP - 121 EP - 30 JF - Restorative neurology and neuroscience JO - Restor. Neurol. Neurosci. VL - 33 IS - 2 N2 - PURPOSE: To investigate the neurologic and functional effect of intracordal hyaluronate injections in acute unilateral vocal fold paralysis (UVFP) in a randomized controlled trial. METHODS: In this open-label, randomized controlled study, 29 patients with UVFP were recruited within 6 months of their first outpatient visit and were randomized to receive either single hyaluronate injection (HI group) or conservative management (CM group). Quantitative laryngeal electromyography, videolaryngostroboscopy, UVFP-related quality of life (Voice Outcomes Survey, VOS), laboratory voice analysis, and health-related quality of life (SF-36) were evaluated at baseline, and at 1, 3 and 6 months post-injection in the HI group, and at baseline and 6 months in the CM group. RESULTS: Improvements in most quality of life domains and other assessments were comparable between the HI and CM groups; however, the HI group had a greater improvement in the mental health domain of quality of life at the end of follow-up. CONCLUSIONS: Early hyaluronate injection cannot improve nerve regeneration but can result in long-lasting improvements in patients' psychosocial well-being, thus highlighting the importance of early intervention for patients with UVFP. SN - 1878-3627 UR - https://www.unboundmedicine.com/medline/citation/25588457/Early_hyaluronate_injection_improves_quality_of_life_but_not_neural_recovery_in_unilateral_vocal_fold_paralysis:_an_open_label_randomized_controlled_study_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/RNN-140439 DB - PRIME DP - Unbound Medicine ER -