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Metabolic syndrome criteria as predictors of subclinical atherosclerosis based on the coronary calcium score.
Korean J Intern Med. 2015 Jan; 30(1):73-81.KJ

Abstract

BACKGROUND/AIMS

The aim was to determine which of three sets of metabolic syndrome (MetS) criteria (International Diabetes Federation [IDF], National Cholesterol Education Program Adult Treatment Panel III [ATP III], and European Group for the Study of Insulin Resistance [EGIR]) best predicts the coronary artery calcification (CAC) score in a cross-sectional study. This has not been evaluated in previous studies.

METHODS

A total of 24,060 subjects were screened for CAC by multi-detector computed tomography. The presence of CAC was defined as a CAC score > 0. The odds ratio for the presence of CAC was analyzed for three different sets of MetS criteria and according to number of MetS components.

RESULTS

CAC was observed in 12.6% (3,037) of the subjects. Patients with MetS, as defined by the IDF, ATP III, and EGIR criteria, had a CAC rate of 23.0%, 25.1%, and 29.5%, respectively (p < 0.001). Comparisons of C statistics for multivariate regression models revealed no significant difference among the three sets of criteria. After adjustment for risk factors, the ATP III criteria produced a slightly higher odds ratio for CAC compared with the other criteria, but this difference was not significant. The risk factor-adjusted odds ratio for the presence of CAC increased from 1 to 1.679 as the number of MetS components defined by ATP III increased from 0 to ≥ 3 (p for trend < 0.001).

CONCLUSIONS

The presence of MetS was associated with the presence of CAC. There was no significant difference among the three sets of MetS criteria in terms of the ability to predict CAC. An increase in the number of MetS components was associated with an increased odds of CAC.

Authors+Show Affiliations

Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University College of Medicine, Gumi, Korea.Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25589838

Citation

Seo, Mi Hae, et al. "Metabolic Syndrome Criteria as Predictors of Subclinical Atherosclerosis Based On the Coronary Calcium Score." The Korean Journal of Internal Medicine, vol. 30, no. 1, 2015, pp. 73-81.
Seo MH, Rhee EJ, Park SE, et al. Metabolic syndrome criteria as predictors of subclinical atherosclerosis based on the coronary calcium score. Korean J Intern Med. 2015;30(1):73-81.
Seo, M. H., Rhee, E. J., Park, S. E., Park, C. Y., Oh, K. W., Park, S. W., & Lee, W. Y. (2015). Metabolic syndrome criteria as predictors of subclinical atherosclerosis based on the coronary calcium score. The Korean Journal of Internal Medicine, 30(1), 73-81. https://doi.org/10.3904/kjim.2015.30.1.73
Seo MH, et al. Metabolic Syndrome Criteria as Predictors of Subclinical Atherosclerosis Based On the Coronary Calcium Score. Korean J Intern Med. 2015;30(1):73-81. PubMed PMID: 25589838.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic syndrome criteria as predictors of subclinical atherosclerosis based on the coronary calcium score. AU - Seo,Mi Hae, AU - Rhee,Eun-Jung, AU - Park,Se Eun, AU - Park,Cheol Young, AU - Oh,Ki Won, AU - Park,Sung Woo, AU - Lee,Won-Young, Y1 - 2014/12/30/ PY - 2014/03/12/received PY - 2014/05/15/revised PY - 2014/08/12/accepted PY - 2015/1/16/entrez PY - 2015/1/16/pubmed PY - 2015/10/23/medline KW - Calcification KW - Coronary artery KW - Metabolic syndrome SP - 73 EP - 81 JF - The Korean journal of internal medicine JO - Korean J Intern Med VL - 30 IS - 1 N2 - BACKGROUND/AIMS: The aim was to determine which of three sets of metabolic syndrome (MetS) criteria (International Diabetes Federation [IDF], National Cholesterol Education Program Adult Treatment Panel III [ATP III], and European Group for the Study of Insulin Resistance [EGIR]) best predicts the coronary artery calcification (CAC) score in a cross-sectional study. This has not been evaluated in previous studies. METHODS: A total of 24,060 subjects were screened for CAC by multi-detector computed tomography. The presence of CAC was defined as a CAC score > 0. The odds ratio for the presence of CAC was analyzed for three different sets of MetS criteria and according to number of MetS components. RESULTS: CAC was observed in 12.6% (3,037) of the subjects. Patients with MetS, as defined by the IDF, ATP III, and EGIR criteria, had a CAC rate of 23.0%, 25.1%, and 29.5%, respectively (p < 0.001). Comparisons of C statistics for multivariate regression models revealed no significant difference among the three sets of criteria. After adjustment for risk factors, the ATP III criteria produced a slightly higher odds ratio for CAC compared with the other criteria, but this difference was not significant. The risk factor-adjusted odds ratio for the presence of CAC increased from 1 to 1.679 as the number of MetS components defined by ATP III increased from 0 to ≥ 3 (p for trend < 0.001). CONCLUSIONS: The presence of MetS was associated with the presence of CAC. There was no significant difference among the three sets of MetS criteria in terms of the ability to predict CAC. An increase in the number of MetS components was associated with an increased odds of CAC. SN - 2005-6648 UR - https://www.unboundmedicine.com/medline/citation/25589838/Metabolic_syndrome_criteria_as_predictors_of_subclinical_atherosclerosis_based_on_the_coronary_calcium_score_ L2 - https://dx.doi.org/10.3904/kjim.2015.30.1.73 DB - PRIME DP - Unbound Medicine ER -