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Inadequate supply of vitamins and DHA in the elderly: implications for brain aging and Alzheimer-type dementia.

Abstract

Alzheimer's disease (AD) is the most prevalent, severe, and disabling cause of dementia worldwide. To date, AD therapy is primarily targeted toward palliative treatment of symptoms rather than prevention of disease progression. So far, no pharmacologic interventions have changed the onset or progression of AD and their use is accompanied by side effects. The major obstacle in managing AD and designing therapeutic strategies is the difficulty in retarding neuronal loss in the diseased brain once the pathologic events leading to neuronal death have started. Therefore, a promising alternative strategy is to maintain a healthy neuronal population in the aging brain for as long as possible. One factor evidently important for neuronal health and function is the optimal supply of nutrients necessary for maintaining normal functioning of the brain. Mechanistic studies, epidemiologic analyses, and randomized controlled intervention trials provide insight to the positive effects of docosahexaenoic acid (DHA) and micronutrients such as the vitamin B family, and vitamins E, C, and D, in helping neurons to cope with aging. These nutrients are inexpensive in use, have virtually no side effects when used at recommended doses, are essential for life, have established modes of action, and are broadly accepted by the general public. This review provides some evidence that the use of vitamins and DHA for the aging population in general, and for individuals at risk in particular, is a viable alternative approach to delaying brain aging and for protecting against the onset of AD pathology.

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  • Authors+Show Affiliations

    ,

    DSM Nutritional Products Ltd., R&D Human Nutrition and Health, Basel, Switzerland. Electronic address: hasan.mohajeri@dsm.com.

    ,

    DSM Nutritional Products Ltd., R&D Human Nutrition and Health, Basel, Switzerland.

    DSM Nutritional Products Ltd., R&D Human Nutrition and Health, Basel, Switzerland.

    Source

    MeSH

    Aging
    Alzheimer Disease
    Brain
    Dietary Supplements
    Disease Progression
    Docosahexaenoic Acids
    Humans
    Malnutrition
    Meta-Analysis as Topic
    Micronutrients
    Neurons
    Nutritional Status
    Randomized Controlled Trials as Topic
    Vitamins

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    25592004

    Citation

    Mohajeri, M Hasan, et al. "Inadequate Supply of Vitamins and DHA in the Elderly: Implications for Brain Aging and Alzheimer-type Dementia." Nutrition (Burbank, Los Angeles County, Calif.), vol. 31, no. 2, 2015, pp. 261-75.
    Mohajeri MH, Troesch B, Weber P. Inadequate supply of vitamins and DHA in the elderly: implications for brain aging and Alzheimer-type dementia. Nutrition. 2015;31(2):261-75.
    Mohajeri, M. H., Troesch, B., & Weber, P. (2015). Inadequate supply of vitamins and DHA in the elderly: implications for brain aging and Alzheimer-type dementia. Nutrition (Burbank, Los Angeles County, Calif.), 31(2), pp. 261-75. doi:10.1016/j.nut.2014.06.016.
    Mohajeri MH, Troesch B, Weber P. Inadequate Supply of Vitamins and DHA in the Elderly: Implications for Brain Aging and Alzheimer-type Dementia. Nutrition. 2015;31(2):261-75. PubMed PMID: 25592004.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Inadequate supply of vitamins and DHA in the elderly: implications for brain aging and Alzheimer-type dementia. AU - Mohajeri,M Hasan, AU - Troesch,Barbara, AU - Weber,Peter, Y1 - 2014/07/24/ PY - 2014/02/12/received PY - 2014/05/27/revised PY - 2014/06/04/accepted PY - 2015/1/17/entrez PY - 2015/1/17/pubmed PY - 2015/10/1/medline KW - Aging KW - Alzheimer KW - Diet KW - Drug therapy KW - Vitamin intake SP - 261 EP - 75 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 31 IS - 2 N2 - Alzheimer's disease (AD) is the most prevalent, severe, and disabling cause of dementia worldwide. To date, AD therapy is primarily targeted toward palliative treatment of symptoms rather than prevention of disease progression. So far, no pharmacologic interventions have changed the onset or progression of AD and their use is accompanied by side effects. The major obstacle in managing AD and designing therapeutic strategies is the difficulty in retarding neuronal loss in the diseased brain once the pathologic events leading to neuronal death have started. Therefore, a promising alternative strategy is to maintain a healthy neuronal population in the aging brain for as long as possible. One factor evidently important for neuronal health and function is the optimal supply of nutrients necessary for maintaining normal functioning of the brain. Mechanistic studies, epidemiologic analyses, and randomized controlled intervention trials provide insight to the positive effects of docosahexaenoic acid (DHA) and micronutrients such as the vitamin B family, and vitamins E, C, and D, in helping neurons to cope with aging. These nutrients are inexpensive in use, have virtually no side effects when used at recommended doses, are essential for life, have established modes of action, and are broadly accepted by the general public. This review provides some evidence that the use of vitamins and DHA for the aging population in general, and for individuals at risk in particular, is a viable alternative approach to delaying brain aging and for protecting against the onset of AD pathology. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/25592004/Inadequate_supply_of_vitamins_and_DHA_in_the_elderly:_implications_for_brain_aging_and_Alzheimer_type_dementia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(14)00339-6 DB - PRIME DP - Unbound Medicine ER -