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Iron metabolism in infants: influence of bovine lactoferrin from iron-fortified formula.
Nutrition 2015; 31(2):304-9N

Abstract

OBJECTIVE

The aim of this study was to evaluate whether an iron-fortified formula with a concentration of lactoferrin would significantly improve the hematologic indexes and iron status in term infants compared with those same values in infants fed an iron-fortified formula without lactoferrin.

METHOD

In this prospective, multicenter, controlled intervention study, 260 infants ages 4 to 6 mo were selected from six maternal and children's health care hospitals in the area. All infants were divided into two groups with the sequence of outpatient: lactoferrin-fortified formula milk group (fortified group, FG, containing lactoferrin 38 mg/100 g milk and iron element 4 mg/100 g milk) and no lactoferrin fortified milk (control group, CG, containing lactoferrin 0 mg/100 g milk and iron element 4 mg/100 g milk) for 3 mo. The levels of weight, height, and head circumference and the concentration of hemoglobin (Hb), serum ferritin (SF), and serum transferring receptor (sTfR) were measured and sTfR-SF index (TFR-F index), total body iron content (TBIC) and low height for age (HAZ), low weight for age (WAZ), and low weight for height (WHZ) were computed before and after the intervention, respectively.

RESULTS

In all, 213 (115 in FG and 98 in CG) infants completed the intervention trial and all measurements of biochemical indicators. There were no significant differences in the average amount of daily intake of formula milk (94.3 ± 9.8 g versus 88.2 ± 8.7 g for FG and CG; P > 0.05) and iron element (3.8 ± 0.4 mg versus 3.7 ± 0.6 mg for FG and CG; P > 0.05). The average amount of daily intake of lactoferrin for infants in FG group was 35.8 ± 3.7 mg. The levels of weight, WAZ, WHZ, Hb, SF, TFR-F index, and TBIC after intervention of infants in FG were all significantly higher than those of infants in CG weight, 8723 ± 245 g versus 8558 ± 214g; WAZ, 1.02 ± 0.31 versus 0.44 ± 0.18; WHZ, 0.98 ± 0.31 versus 0.41 ± 0.12; Hb, 125.5 ± 15.4 g/L versus 116.9 ± 13.1 g/L; SF, 44.7 ± 17.2 μg/L versus 31.6 ± 18.4 μg/L; TFR-F index, 1.88 ± 0.41 versus 1.26 ± 0.39; TBIC, 6.12 ± 0.78 mg/kg versus 5.26 ± 0.55 mg/kg for FG and CG; P < 0.05), but significantly lower (P < 0.05) for the prevalence of anemia (4.1% versus 7.5%), iron deficiency (13.9% versus 24.4%), and iron-deficient anemia (1.7% versus 6.1%).

CONCLUSION

When infants who were exclusively breastfed were supplemented with lactoferrin-fortified milk, significant increases in TBIC and iron absorption in the intestine were seen.

Authors+Show Affiliations

Department of Child Health Care, Chengdu Women's and Children's Central Hospital, Chengdu, Sichuan, China.Department of Child Health Care, Chengdu Women's and Children's Central Hospital, Chengdu, Sichuan, China.Department of Preventive Health Care, Women and Children's Health Care Hospital of Qing Baijing, Qing Baijing District, Chengdu, Sichuan, China.Department of Child Health Care, Women and Children's Health Care Hospital of Jinniu, Jinniu District, Chengdu, Sichuan, China.Department of Child Health Care, Women and Children's Health Care Hospital of Dayi, Dayi County, Chengdu, Sichuan, China.Department of Child Health Care, Women and Children's Health Care Hospital of Chenghua, Chenghua District, Chengdu, Sichuan, China.Department of Pediatrics, Women and Children's Health Care Hospital of Dongpo, Dongpo District, Meishan, Sichuan, China.Department of Child Health Care, Women and Children's Health Care Hospital of Xindu, Xindu District, Chengdu, Sichuan, China.Beingmate Baby & Child Food Co., Ltd, Hangzhou, Zhejiang, China.Chengdu Women's and Children's Central Hospital, Chengdu, Sichuan, China. Electronic address: mmcdfy@163.com.

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

25592008

Citation

Ke, Chen, et al. "Iron Metabolism in Infants: Influence of Bovine Lactoferrin From Iron-fortified Formula." Nutrition (Burbank, Los Angeles County, Calif.), vol. 31, no. 2, 2015, pp. 304-9.
Ke C, Lan Z, Hua L, et al. Iron metabolism in infants: influence of bovine lactoferrin from iron-fortified formula. Nutrition. 2015;31(2):304-9.
Ke, C., Lan, Z., Hua, L., Ying, Z., Humina, X., Jia, S., ... Meng, M. (2015). Iron metabolism in infants: influence of bovine lactoferrin from iron-fortified formula. Nutrition (Burbank, Los Angeles County, Calif.), 31(2), pp. 304-9. doi:10.1016/j.nut.2014.07.006.
Ke C, et al. Iron Metabolism in Infants: Influence of Bovine Lactoferrin From Iron-fortified Formula. Nutrition. 2015;31(2):304-9. PubMed PMID: 25592008.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Iron metabolism in infants: influence of bovine lactoferrin from iron-fortified formula. AU - Ke,Chen, AU - Lan,Zhang, AU - Hua,Li, AU - Ying,Zhang, AU - Humina,Xie, AU - Jia,Shang, AU - Weizheng,Tian, AU - Ping,Yang, AU - Lingying,Chai, AU - Meng,Mao, Y1 - 2014/08/01/ PY - 2014/04/05/received PY - 2014/07/09/revised PY - 2014/07/22/accepted PY - 2015/1/17/entrez PY - 2015/1/17/pubmed PY - 2015/10/1/medline KW - Breastfeeding KW - Growth and development KW - Infants KW - Iron metabolic homeostasis KW - Lactoferrin SP - 304 EP - 9 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 31 IS - 2 N2 - OBJECTIVE: The aim of this study was to evaluate whether an iron-fortified formula with a concentration of lactoferrin would significantly improve the hematologic indexes and iron status in term infants compared with those same values in infants fed an iron-fortified formula without lactoferrin. METHOD: In this prospective, multicenter, controlled intervention study, 260 infants ages 4 to 6 mo were selected from six maternal and children's health care hospitals in the area. All infants were divided into two groups with the sequence of outpatient: lactoferrin-fortified formula milk group (fortified group, FG, containing lactoferrin 38 mg/100 g milk and iron element 4 mg/100 g milk) and no lactoferrin fortified milk (control group, CG, containing lactoferrin 0 mg/100 g milk and iron element 4 mg/100 g milk) for 3 mo. The levels of weight, height, and head circumference and the concentration of hemoglobin (Hb), serum ferritin (SF), and serum transferring receptor (sTfR) were measured and sTfR-SF index (TFR-F index), total body iron content (TBIC) and low height for age (HAZ), low weight for age (WAZ), and low weight for height (WHZ) were computed before and after the intervention, respectively. RESULTS: In all, 213 (115 in FG and 98 in CG) infants completed the intervention trial and all measurements of biochemical indicators. There were no significant differences in the average amount of daily intake of formula milk (94.3 ± 9.8 g versus 88.2 ± 8.7 g for FG and CG; P > 0.05) and iron element (3.8 ± 0.4 mg versus 3.7 ± 0.6 mg for FG and CG; P > 0.05). The average amount of daily intake of lactoferrin for infants in FG group was 35.8 ± 3.7 mg. The levels of weight, WAZ, WHZ, Hb, SF, TFR-F index, and TBIC after intervention of infants in FG were all significantly higher than those of infants in CG weight, 8723 ± 245 g versus 8558 ± 214g; WAZ, 1.02 ± 0.31 versus 0.44 ± 0.18; WHZ, 0.98 ± 0.31 versus 0.41 ± 0.12; Hb, 125.5 ± 15.4 g/L versus 116.9 ± 13.1 g/L; SF, 44.7 ± 17.2 μg/L versus 31.6 ± 18.4 μg/L; TFR-F index, 1.88 ± 0.41 versus 1.26 ± 0.39; TBIC, 6.12 ± 0.78 mg/kg versus 5.26 ± 0.55 mg/kg for FG and CG; P < 0.05), but significantly lower (P < 0.05) for the prevalence of anemia (4.1% versus 7.5%), iron deficiency (13.9% versus 24.4%), and iron-deficient anemia (1.7% versus 6.1%). CONCLUSION: When infants who were exclusively breastfed were supplemented with lactoferrin-fortified milk, significant increases in TBIC and iron absorption in the intestine were seen. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/25592008/Iron_metabolism_in_infants:_influence_of_bovine_lactoferrin_from_iron_fortified_formula_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(14)00345-1 DB - PRIME DP - Unbound Medicine ER -