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Clinical disease due to enterovirus D68 in adult hematologic malignancy patients and hematopoietic cell transplant recipients.
Blood. 2015 Mar 12; 125(11):1724-9.Blood

Abstract

The United States Centers for Disease Control and Prevention reported over 1000 cases of severe respiratory disease in pediatric patients associated with enterovirus D68 (EV-D68) in the fall of 2014. We sought to identify and define the clinical burden of disease due to EV-D68 in adult patients with hematologic malignancy or undergoing hematopoietic cell transplant (HCT). Real-time reverse-transcriptase polymerase chain reaction (PCR) for EV-D68 was performed on all respiratory samples positive for human rhinovirus (HRV) or negative for all respiratory viruses by a laboratory-developed respiratory viral PCR panel from August 11, 2014, to November 7, 2014. Presumptive cases were defined as those with an EV-D68 PCR cycle threshold (CT) at least 4 cycles lower than the HRV CT for HRV-positive samples or any EV-D68 CT value for HRV-negative samples. Sequencing of a 150-bp fragment of the 5' noncoding region confirmed EV-D68 in 16 of 506 respiratory samples. Eight patients had a history of hematologic malignancy, and 6 of these had undergone HCT. Presentation ranged from mild upper respiratory symptoms to respiratory failure. EV-D68 can infect adult patients with hematologic malignancy and HCT recipients and may be associated with severe respiratory disease. Current commercial diagnostic assays cannot differentiate EV-D68 from other enteroviruses or HRV, and improved rapid diagnostic tools are needed.

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Authors+Show Affiliations

Waghmare A
Department of Pediatrics, Division of Infectious Diseases, University of Washington, Seattle, WA; Seattle Children's Hospital, Seattle, WA; Fred Hutchinson Cancer Research Center, Seattle, WA;
Pergam SA
Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Medicine, Division of Allergy and Infectious Diseases, and.
Jerome KR
Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Laboratory Medicine, Division of Virology, University of Washington, Seattle, WA.
Englund JA
Department of Pediatrics, Division of Infectious Diseases, University of Washington, Seattle, WA; Seattle Children's Hospital, Seattle, WA;
Boeckh M
Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Medicine, Division of Allergy and Infectious Diseases, and.
Kuypers J
Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Laboratory Medicine, Division of Virology, University of Washington, Seattle, WA.

MeSH

AdultAgedBase SequenceDNA, ViralEnterovirus D, HumanEnterovirus InfectionsFemaleHematologic NeoplasmsHematopoietic Stem Cell TransplantationHumansImmunocompromised HostMaleMiddle AgedRespiratory Tract InfectionsRhinovirusYoung Adult

Pub Type(s)

Case Reports
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25593338

Citation

Waghmare, Alpana, et al. "Clinical Disease Due to Enterovirus D68 in Adult Hematologic Malignancy Patients and Hematopoietic Cell Transplant Recipients." Blood, vol. 125, no. 11, 2015, pp. 1724-9.
Waghmare A, Pergam SA, Jerome KR, et al. Clinical disease due to enterovirus D68 in adult hematologic malignancy patients and hematopoietic cell transplant recipients. Blood. 2015;125(11):1724-9.
Waghmare, A., Pergam, S. A., Jerome, K. R., Englund, J. A., Boeckh, M., & Kuypers, J. (2015). Clinical disease due to enterovirus D68 in adult hematologic malignancy patients and hematopoietic cell transplant recipients. Blood, 125(11), 1724-9. https://doi.org/10.1182/blood-2014-12-616516
Waghmare A, et al. Clinical Disease Due to Enterovirus D68 in Adult Hematologic Malignancy Patients and Hematopoietic Cell Transplant Recipients. Blood. 2015 Mar 12;125(11):1724-9. PubMed PMID: 25593338.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical disease due to enterovirus D68 in adult hematologic malignancy patients and hematopoietic cell transplant recipients. AU - Waghmare,Alpana, AU - Pergam,Steven A, AU - Jerome,Keith R, AU - Englund,Janet A, AU - Boeckh,Michael, AU - Kuypers,Jane, Y1 - 2015/01/15/ PY - 2015/1/17/entrez PY - 2015/1/17/pubmed PY - 2015/6/24/medline SP - 1724 EP - 9 JF - Blood JO - Blood VL - 125 IS - 11 N2 - The United States Centers for Disease Control and Prevention reported over 1000 cases of severe respiratory disease in pediatric patients associated with enterovirus D68 (EV-D68) in the fall of 2014. We sought to identify and define the clinical burden of disease due to EV-D68 in adult patients with hematologic malignancy or undergoing hematopoietic cell transplant (HCT). Real-time reverse-transcriptase polymerase chain reaction (PCR) for EV-D68 was performed on all respiratory samples positive for human rhinovirus (HRV) or negative for all respiratory viruses by a laboratory-developed respiratory viral PCR panel from August 11, 2014, to November 7, 2014. Presumptive cases were defined as those with an EV-D68 PCR cycle threshold (CT) at least 4 cycles lower than the HRV CT for HRV-positive samples or any EV-D68 CT value for HRV-negative samples. Sequencing of a 150-bp fragment of the 5' noncoding region confirmed EV-D68 in 16 of 506 respiratory samples. Eight patients had a history of hematologic malignancy, and 6 of these had undergone HCT. Presentation ranged from mild upper respiratory symptoms to respiratory failure. EV-D68 can infect adult patients with hematologic malignancy and HCT recipients and may be associated with severe respiratory disease. Current commercial diagnostic assays cannot differentiate EV-D68 from other enteroviruses or HRV, and improved rapid diagnostic tools are needed. SN - 1528-0020 UR - https://www.unboundmedicine.com/medline/citation/25593338/Clinical_disease_due_to_enterovirus_D68_in_adult_hematologic_malignancy_patients_and_hematopoietic_cell_transplant_recipients_ DB - PRIME DP - Unbound Medicine ER -