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Central obesity is predictive of persistent storage lower urinary tract symptoms (LUTS) after surgery for benign prostatic enlargement: results of a multicentre prospective study.
BJU Int. 2015 Aug; 116(2):271-7.BI

Abstract

OBJECTIVE

To evaluate the impact of components of metabolic syndrome (MetS) on urinary outcomes after surgery for severe lower urinary tract symptoms (LUTS) due to benign prostatic enlargement (BPE), as central obesity can be associated with the development of BPE and with the worsening of LUTS.

PATIENTS AND METHODS

A multicentre prospective study was conducted including 378 consecutive men surgically treated for large BPE with simple open prostatectomy (OP) or transurethral resection of the prostate (TURP), between January 2012 and October 2013. LUTS were measured by the International Prostate Symptom Score (IPSS), immediately before surgery and at 6-12 months postoperatively. MetS was defined according the USA National Cholesterol Education Program-Adult Treatment Panel III.

RESULTS

The improvement of total and storage IPSS postoperatively was related to diastolic blood pressure and waist circumference (WC). A WC of >102 cm was associated with a higher risk of an incomplete recovery of both total IPSS (odds ratio [OR] 0.343, P = 0.001) and storage IPSS (OR 0.208, P < 0.001), as compared with a WC of <102 cm. The main limitations were: (i) population selected from a tertiary centre, (ii) Use exclusively of IPSS questionnaire, and (iii) No inclusion of further data.

CONCLUSIONS

Increased WC is associated with persistent postoperative urinary symptoms after surgical treatment of BPE. Obese men have a higher risk of persistent storage LUTS after TURP or OP.

Authors+Show Affiliations

Department of Urology, Careggi Hospital, University of Florence, Florence, Italy.Department of Urology, Careggi Hospital, University of Florence, Florence, Italy.Department of Urology, Careggi Hospital, University of Florence, Florence, Italy.Department of Urology, Sant'Andrea Hospital, University 'La Sapienza', Rome, Italy.Department of Urology, Sant'Andrea Hospital, University 'La Sapienza', Rome, Italy.Department of Clinical Physiopathology, University of Florence, Florence, Italy.Endocrinology Unit, Medical Department, Maggiore-Bellaria Hospital, Bologna, Italy.Department of Urology, Southern Illinois University School of Medicine, Springfield, IL, USA.Department of Urology, Weill Cornell Medical College, Cornell University, New York, NY, USA.Department of Clinical Physiopathology, University of Florence, Florence, Italy.Department of Urology, Careggi Hospital, University of Florence, Florence, Italy.Department of Urology, Careggi Hospital, University of Florence, Florence, Italy.

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

25597623

Citation

Gacci, Mauro, et al. "Central Obesity Is Predictive of Persistent Storage Lower Urinary Tract Symptoms (LUTS) After Surgery for Benign Prostatic Enlargement: Results of a Multicentre Prospective Study." BJU International, vol. 116, no. 2, 2015, pp. 271-7.
Gacci M, Sebastianelli A, Salvi M, et al. Central obesity is predictive of persistent storage lower urinary tract symptoms (LUTS) after surgery for benign prostatic enlargement: results of a multicentre prospective study. BJU Int. 2015;116(2):271-7.
Gacci, M., Sebastianelli, A., Salvi, M., De Nunzio, C., Tubaro, A., Vignozzi, L., Corona, G., McVary, K. T., Kaplan, S. A., Maggi, M., Carini, M., & Serni, S. (2015). Central obesity is predictive of persistent storage lower urinary tract symptoms (LUTS) after surgery for benign prostatic enlargement: results of a multicentre prospective study. BJU International, 116(2), 271-7. https://doi.org/10.1111/bju.13038
Gacci M, et al. Central Obesity Is Predictive of Persistent Storage Lower Urinary Tract Symptoms (LUTS) After Surgery for Benign Prostatic Enlargement: Results of a Multicentre Prospective Study. BJU Int. 2015;116(2):271-7. PubMed PMID: 25597623.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Central obesity is predictive of persistent storage lower urinary tract symptoms (LUTS) after surgery for benign prostatic enlargement: results of a multicentre prospective study. AU - Gacci,Mauro, AU - Sebastianelli,Arcangelo, AU - Salvi,Matteo, AU - De Nunzio,Cosimo, AU - Tubaro,Andrea, AU - Vignozzi,Linda, AU - Corona,Giovanni, AU - McVary,Kevin T, AU - Kaplan,Steven A, AU - Maggi,Mario, AU - Carini,Marco, AU - Serni,Sergio, Y1 - 2015/04/20/ PY - 2015/1/20/entrez PY - 2015/1/20/pubmed PY - 2015/10/17/medline KW - benign prostatic enlargement KW - benign prostatic hyperplasia KW - lower urinary tract symptoms KW - metabolic syndrome KW - waist circumference SP - 271 EP - 7 JF - BJU international JO - BJU Int VL - 116 IS - 2 N2 - OBJECTIVE: To evaluate the impact of components of metabolic syndrome (MetS) on urinary outcomes after surgery for severe lower urinary tract symptoms (LUTS) due to benign prostatic enlargement (BPE), as central obesity can be associated with the development of BPE and with the worsening of LUTS. PATIENTS AND METHODS: A multicentre prospective study was conducted including 378 consecutive men surgically treated for large BPE with simple open prostatectomy (OP) or transurethral resection of the prostate (TURP), between January 2012 and October 2013. LUTS were measured by the International Prostate Symptom Score (IPSS), immediately before surgery and at 6-12 months postoperatively. MetS was defined according the USA National Cholesterol Education Program-Adult Treatment Panel III. RESULTS: The improvement of total and storage IPSS postoperatively was related to diastolic blood pressure and waist circumference (WC). A WC of >102 cm was associated with a higher risk of an incomplete recovery of both total IPSS (odds ratio [OR] 0.343, P = 0.001) and storage IPSS (OR 0.208, P < 0.001), as compared with a WC of <102 cm. The main limitations were: (i) population selected from a tertiary centre, (ii) Use exclusively of IPSS questionnaire, and (iii) No inclusion of further data. CONCLUSIONS: Increased WC is associated with persistent postoperative urinary symptoms after surgical treatment of BPE. Obese men have a higher risk of persistent storage LUTS after TURP or OP. SN - 1464-410X UR - https://www.unboundmedicine.com/medline/citation/25597623/Central_obesity_is_predictive_of_persistent_storage_lower_urinary_tract_symptoms__LUTS__after_surgery_for_benign_prostatic_enlargement:_results_of_a_multicentre_prospective_study_ L2 - https://doi.org/10.1111/bju.13038 DB - PRIME DP - Unbound Medicine ER -