Tags

Type your tag names separated by a space and hit enter

Diet, lifestyle, and genetic risk factors for type 2 diabetes: a review from the Nurses' Health Study, Nurses' Health Study 2, and Health Professionals' Follow-up Study.
Curr Nutr Rep 2014; 3(4):345-354CN

Abstract

The epidemiological evidence collected from three large US cohorts (Nurses' Health Study, Nurses' Health Study 2, and Health Professionals' Follow-up Study) has yielded important information regarding the roles of overall diet, individual foods and nutrients, physical activity and other lifestyle factors in the development of type 2 diabetes. Excess adiposity is a major risk factor for diabetes, and thus, maintaining a healthy body weight and avoidance of weight gain during adulthood is the cornerstone of diabetes prevention. Independent of body weight, the quality or type of dietary fat and carbohydrate is more crucial than the quantity in determining diabetes risk. Higher consumption of coffee, whole grains, fruits, and nuts is associated with lower risk of diabetes, whereas regular consumption of refined grains, red and processed meats, and sugar-sweetened beverages including fruits juices is associated with increased risk. Dietary patterns rich in fruits and vegetables, whole grains, and nuts and legumes but lower in red and processed meats, refined grains, and sugar-sweetened beverages are consistently associated with diabetes risk, even after adjustment for body mass index. The genome-wide association studies conducted in these cohorts have contributed substantially to the discoveries of novel genetic loci for type 2 diabetes and other metabolic traits, although the identified common variants explain only a small proportion of overall diabetes predisposition. Taken together, these ongoing large cohort studies have provided convincing epidemiologic evidence that a healthy diet, together with regular physical activity, maintenance of a healthy weight, moderate alcohol consumption, and avoidance of sedentary behaviors and smoking would prevent the majority of type 2 diabetes cases.

Authors+Show Affiliations

Department of Nutrition, Harvard School of Public Health. Boston, MA, USA.Departments of Nutrition and Epidemiology, Harvard School of Public Health. Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School.Departments of Nutrition and Epidemiology, Harvard School of Public Health. Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25599007

Citation

Ardisson Korat, Andres V., et al. "Diet, Lifestyle, and Genetic Risk Factors for Type 2 Diabetes: a Review From the Nurses' Health Study, Nurses' Health Study 2, and Health Professionals' Follow-up Study." Current Nutrition Reports, vol. 3, no. 4, 2014, pp. 345-354.
Ardisson Korat AV, Willett WC, Hu FB. Diet, lifestyle, and genetic risk factors for type 2 diabetes: a review from the Nurses' Health Study, Nurses' Health Study 2, and Health Professionals' Follow-up Study. Curr Nutr Rep. 2014;3(4):345-354.
Ardisson Korat, A. V., Willett, W. C., & Hu, F. B. (2014). Diet, lifestyle, and genetic risk factors for type 2 diabetes: a review from the Nurses' Health Study, Nurses' Health Study 2, and Health Professionals' Follow-up Study. Current Nutrition Reports, 3(4), pp. 345-354.
Ardisson Korat AV, Willett WC, Hu FB. Diet, Lifestyle, and Genetic Risk Factors for Type 2 Diabetes: a Review From the Nurses' Health Study, Nurses' Health Study 2, and Health Professionals' Follow-up Study. Curr Nutr Rep. 2014 Dec 1;3(4):345-354. PubMed PMID: 25599007.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diet, lifestyle, and genetic risk factors for type 2 diabetes: a review from the Nurses' Health Study, Nurses' Health Study 2, and Health Professionals' Follow-up Study. AU - Ardisson Korat,Andres V, AU - Willett,Walter C, AU - Hu,Frank B, PY - 2015/1/20/entrez PY - 2015/1/20/pubmed PY - 2015/1/20/medline KW - Body Mass Index KW - Diet KW - Dietary Patterns KW - Health Professionals Follow-up Study KW - Nurses Health Study KW - Physical Activity KW - Prudent diet KW - Type 2 Diabetes mellitus KW - Western diet SP - 345 EP - 354 JF - Current nutrition reports JO - Curr Nutr Rep VL - 3 IS - 4 N2 - The epidemiological evidence collected from three large US cohorts (Nurses' Health Study, Nurses' Health Study 2, and Health Professionals' Follow-up Study) has yielded important information regarding the roles of overall diet, individual foods and nutrients, physical activity and other lifestyle factors in the development of type 2 diabetes. Excess adiposity is a major risk factor for diabetes, and thus, maintaining a healthy body weight and avoidance of weight gain during adulthood is the cornerstone of diabetes prevention. Independent of body weight, the quality or type of dietary fat and carbohydrate is more crucial than the quantity in determining diabetes risk. Higher consumption of coffee, whole grains, fruits, and nuts is associated with lower risk of diabetes, whereas regular consumption of refined grains, red and processed meats, and sugar-sweetened beverages including fruits juices is associated with increased risk. Dietary patterns rich in fruits and vegetables, whole grains, and nuts and legumes but lower in red and processed meats, refined grains, and sugar-sweetened beverages are consistently associated with diabetes risk, even after adjustment for body mass index. The genome-wide association studies conducted in these cohorts have contributed substantially to the discoveries of novel genetic loci for type 2 diabetes and other metabolic traits, although the identified common variants explain only a small proportion of overall diabetes predisposition. Taken together, these ongoing large cohort studies have provided convincing epidemiologic evidence that a healthy diet, together with regular physical activity, maintenance of a healthy weight, moderate alcohol consumption, and avoidance of sedentary behaviors and smoking would prevent the majority of type 2 diabetes cases. SN - 2161-3311 UR - https://www.unboundmedicine.com/medline/citation/25599007/full_citation L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25599007/ DB - PRIME DP - Unbound Medicine ER -