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Physical Activity, Mediterranean Diet and Biomarkers-Assessed Risk of Alzheimer's: A Multi-Modality Brain Imaging Study.
Adv J Mol Imaging. 2014 Oct; 4(4):43-57.AJ

Abstract

Increased physical activity and higher adherence to a Mediterranean-type diet (MeDi) have been independently associated with reduced risk of Alzheimer's disease (AD). Their association has not been investigated with the use of biomarkers. This study examines whether, among cognitively normal (NL) individuals, those who are less physically active and show lower MeDi adherence have brain biomarker abnormalities consistent with AD.

METHODS

Forty-five NL individuals (age 54 ± 11, 71% women) with complete leisure time physical activity (LTA), dietary information, and cross-sectional 3D T1-weigthed MRI, 11C-Pittsburgh Compound B (PiB) and 18F-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) scans were examined. Voxel-wise multivariate partial least square (PLS) regression was used to examine the effects of LTA, MeDi and their interaction on brain biomarkers. Age, gender, ethnicity, education, caloric intake, BMI, family history of AD, Apolipoprotein E (APOE) genotype, presence of hypertension and insulin resistance were examined as confounds. Subjects were dichotomized into more and less physically active (LTA+ vs. LTA-; n = 21 vs. 24), and into higher vs. lower MeDi adherence groups (n = 18 vs. 27) using published scoring methods. Spatial patterns of brain biomarkers that represented the optimal association between the images and the groups were generated for all modalities using voxel-wise multivariate Partial Least Squares (PLS) regression.

RESULTS

Groups were comparable for clinical and neuropsychological measures. Independent effects of LTA and MeDi factors were observed in AD-vulnerable brain regions for all modalities (p < 0.001). Increased AD-burden (in particular higher Aβ load and lower glucose metabolism) were observed in LTA- compared to LTA+ subjects, and in MeDi- as compared to MeDi+ subjects. A gradient effect was observed for all modalities so that LTA-/MeDi- subjects had the highest and LTA+/MeDi+ subjects had the lowest AD-burden (p < 0.001), although the LTA × MeDi interaction was significant only for FDG measures (p < 0.03). Adjusting for covariates did not attenuate these relationships.

CONCLUSION

Lower physical activity and MeDi adherence were associated with increased brain AD-burden among NL individuals, indicating that lifestyle factors may modulate AD risk. Studies with larger samples and longitudinal evaluations are needed to determine the predictive power of the observed associations.

Authors+Show Affiliations

ADM Diagnostics, Chicago, USA.Department of Psychiatry, New York University School of Medicine, New York, USA.Department of Psychiatry, New York University School of Medicine, New York, USA.Department of Psychiatry, New York University School of Medicine, New York, USA.Department of Psychiatry, New York University School of Medicine, New York, USA.Department of Psychiatry, New York University School of Medicine, New York, USA.ADM Diagnostics, Chicago, USA.ADM Diagnostics, Chicago, USA.Department of Psychiatry, New York University School of Medicine, New York, USA.Citigroup Biomedical Imaging Center, Weill Cornell Medical College, New York, USA.Department of Psychiatry, New York University School of Medicine, New York, USA.Department of Psychiatry, New York University School of Medicine, New York, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25599008

Citation

Matthews, Dawn C., et al. "Physical Activity, Mediterranean Diet and Biomarkers-Assessed Risk of Alzheimer's: a Multi-Modality Brain Imaging Study." Advances in Molecular Imaging, vol. 4, no. 4, 2014, pp. 43-57.
Matthews DC, Davies M, Murray J, et al. Physical Activity, Mediterranean Diet and Biomarkers-Assessed Risk of Alzheimer's: A Multi-Modality Brain Imaging Study. Adv J Mol Imaging. 2014;4(4):43-57.
Matthews, D. C., Davies, M., Murray, J., Williams, S., Tsui, W. H., Li, Y., Andrews, R. D., Lukic, A., McHugh, P., Vallabhajosula, S., de Leon, M. J., & Mosconi, L. (2014). Physical Activity, Mediterranean Diet and Biomarkers-Assessed Risk of Alzheimer's: A Multi-Modality Brain Imaging Study. Advances in Molecular Imaging, 4(4), 43-57.
Matthews DC, et al. Physical Activity, Mediterranean Diet and Biomarkers-Assessed Risk of Alzheimer's: a Multi-Modality Brain Imaging Study. Adv J Mol Imaging. 2014;4(4):43-57. PubMed PMID: 25599008.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Physical Activity, Mediterranean Diet and Biomarkers-Assessed Risk of Alzheimer's: A Multi-Modality Brain Imaging Study. AU - Matthews,Dawn C, AU - Davies,Michelle, AU - Murray,John, AU - Williams,Schantel, AU - Tsui,Wai H, AU - Li,Yi, AU - Andrews,Randolph D, AU - Lukic,Ana, AU - McHugh,Pauline, AU - Vallabhajosula,Shankar, AU - de Leon,Mony J, AU - Mosconi,Lisa, PY - 2015/1/20/entrez PY - 2015/1/20/pubmed PY - 2015/1/20/medline KW - Alzheimer’s Disease KW - Amyloid KW - Brain Aging KW - Early Detection KW - Glucose Metabolism KW - MRI KW - Mediterranean Diet KW - PET Imaging KW - Physical activity SP - 43 EP - 57 JF - Advances in molecular imaging JO - Adv J Mol Imaging VL - 4 IS - 4 N2 - : Increased physical activity and higher adherence to a Mediterranean-type diet (MeDi) have been independently associated with reduced risk of Alzheimer's disease (AD). Their association has not been investigated with the use of biomarkers. This study examines whether, among cognitively normal (NL) individuals, those who are less physically active and show lower MeDi adherence have brain biomarker abnormalities consistent with AD. METHODS: Forty-five NL individuals (age 54 ± 11, 71% women) with complete leisure time physical activity (LTA), dietary information, and cross-sectional 3D T1-weigthed MRI, 11C-Pittsburgh Compound B (PiB) and 18F-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) scans were examined. Voxel-wise multivariate partial least square (PLS) regression was used to examine the effects of LTA, MeDi and their interaction on brain biomarkers. Age, gender, ethnicity, education, caloric intake, BMI, family history of AD, Apolipoprotein E (APOE) genotype, presence of hypertension and insulin resistance were examined as confounds. Subjects were dichotomized into more and less physically active (LTA+ vs. LTA-; n = 21 vs. 24), and into higher vs. lower MeDi adherence groups (n = 18 vs. 27) using published scoring methods. Spatial patterns of brain biomarkers that represented the optimal association between the images and the groups were generated for all modalities using voxel-wise multivariate Partial Least Squares (PLS) regression. RESULTS: Groups were comparable for clinical and neuropsychological measures. Independent effects of LTA and MeDi factors were observed in AD-vulnerable brain regions for all modalities (p < 0.001). Increased AD-burden (in particular higher Aβ load and lower glucose metabolism) were observed in LTA- compared to LTA+ subjects, and in MeDi- as compared to MeDi+ subjects. A gradient effect was observed for all modalities so that LTA-/MeDi- subjects had the highest and LTA+/MeDi+ subjects had the lowest AD-burden (p < 0.001), although the LTA × MeDi interaction was significant only for FDG measures (p < 0.03). Adjusting for covariates did not attenuate these relationships. CONCLUSION: Lower physical activity and MeDi adherence were associated with increased brain AD-burden among NL individuals, indicating that lifestyle factors may modulate AD risk. Studies with larger samples and longitudinal evaluations are needed to determine the predictive power of the observed associations. SN - 2161-6728 UR - https://www.unboundmedicine.com/medline/citation/25599008/Physical_Activity_Mediterranean_Diet_and_Biomarkers_Assessed_Risk_of_Alzheimer's:_A_Multi_Modality_Brain_Imaging_Study_ DB - PRIME DP - Unbound Medicine ER -