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In vitro-in vivo evaluation of xanthan gum and eudragit inter polyelectrolyte complex based sustained release tablets.
Int J Pharm Investig. 2015 Jan-Mar; 5(1):65-72.IJ

Abstract

INTRODUCTION

Polyelectrolyte complexes (PECs) are the association complexes formed between oppositely charged particles (e.g., polymer-polymer, polymer-drug and polymer-drug-polymer). These are formed due to electrostatic interaction between oppositely charged polyions. Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) advocated in use of painful and inflammatory rheumatic and certain non-rheumatic conditions. The drug has a relatively short elimination half-life, which limits the potential for drug accumulation. As an analgesic, it has a fast onset and long duration of action.

AIM

invitro-invivo evaluation of Xanthan gum and Eudragit E100 inter polyelectrolyte complex based sustained release tablet.

MATERIALS AND METHOD

Xanthan gum and Eudragit E100 were used as PEC and were prepared using different proportions i.e. in 1:1 to 1:6 ratio. The optimum ratio of E100 and XG was 1:6 used to characterize the IPC and the formulation of tablet. The tablets were prepared by wet granulation using PVP K30 as binder.

RESULTS AND DISCUSSION

FT-IR and DSC studies confirmed the formation of IPC. Scanning Electron Microscopy (SEM) studies showed highly porous tablet surface. The tablets were evaluated for hardness, weight variation, and drug content, found to be within limits. In vitro and in vivo studies concluded that tablets showed sustained release profile. The short term stability study of the optimized formulation indicated that the formulation was stable.

CONCLUSION

Since the Poly Electrolyte Complex delay the release of the drug, it can be employed in formulating sustained release matrix tablets.

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Authors+Show Affiliations

Deb TK
Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Mysore, Karnataka, India.
Ramireddy B
Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Mysore, Karnataka, India.
Moin A
Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Mysore, Karnataka, India.
Shivakumar HG
Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Mysore, Karnataka, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25599035

Citation

Deb, Tamal Krishna, et al. "In Vitro-in Vivo Evaluation of Xanthan Gum and Eudragit Inter Polyelectrolyte Complex Based Sustained Release Tablets." International Journal of Pharmaceutical Investigation, vol. 5, no. 1, 2015, pp. 65-72.
Deb TK, Ramireddy B, Moin A, et al. In vitro-in vivo evaluation of xanthan gum and eudragit inter polyelectrolyte complex based sustained release tablets. Int J Pharm Investig. 2015;5(1):65-72.
Deb, T. K., Ramireddy, B., Moin, A., & Shivakumar, H. G. (2015). In vitro-in vivo evaluation of xanthan gum and eudragit inter polyelectrolyte complex based sustained release tablets. International Journal of Pharmaceutical Investigation, 5(1), 65-72. https://doi.org/10.4103/2230-973X.147236
Deb TK, et al. In Vitro-in Vivo Evaluation of Xanthan Gum and Eudragit Inter Polyelectrolyte Complex Based Sustained Release Tablets. Int J Pharm Investig. 2015 Jan-Mar;5(1):65-72. PubMed PMID: 25599035.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro-in vivo evaluation of xanthan gum and eudragit inter polyelectrolyte complex based sustained release tablets. AU - Deb,Tamal Krishna, AU - Ramireddy,B, AU - Moin,Afrasim, AU - Shivakumar,H G, PY - 2015/1/20/entrez PY - 2015/1/20/pubmed PY - 2015/1/20/medline KW - Diclofenac sodium KW - eudragit KW - inter polyelectrolyte complex KW - sustained release KW - xanthan gum SP - 65 EP - 72 JF - International journal of pharmaceutical investigation JO - Int J Pharm Investig VL - 5 IS - 1 N2 - INTRODUCTION: Polyelectrolyte complexes (PECs) are the association complexes formed between oppositely charged particles (e.g., polymer-polymer, polymer-drug and polymer-drug-polymer). These are formed due to electrostatic interaction between oppositely charged polyions. Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) advocated in use of painful and inflammatory rheumatic and certain non-rheumatic conditions. The drug has a relatively short elimination half-life, which limits the potential for drug accumulation. As an analgesic, it has a fast onset and long duration of action. AIM: invitro-invivo evaluation of Xanthan gum and Eudragit E100 inter polyelectrolyte complex based sustained release tablet. MATERIALS AND METHOD: Xanthan gum and Eudragit E100 were used as PEC and were prepared using different proportions i.e. in 1:1 to 1:6 ratio. The optimum ratio of E100 and XG was 1:6 used to characterize the IPC and the formulation of tablet. The tablets were prepared by wet granulation using PVP K30 as binder. RESULTS AND DISCUSSION: FT-IR and DSC studies confirmed the formation of IPC. Scanning Electron Microscopy (SEM) studies showed highly porous tablet surface. The tablets were evaluated for hardness, weight variation, and drug content, found to be within limits. In vitro and in vivo studies concluded that tablets showed sustained release profile. The short term stability study of the optimized formulation indicated that the formulation was stable. CONCLUSION: Since the Poly Electrolyte Complex delay the release of the drug, it can be employed in formulating sustained release matrix tablets. SN - 2230-973X UR - https://www.unboundmedicine.com/medline/citation/25599035/In_vitro_in_vivo_evaluation_of_xanthan_gum_and_eudragit_inter_polyelectrolyte_complex_based_sustained_release_tablets_ DB - PRIME DP - Unbound Medicine ER -