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Intravenous self-administration of mephedrone, methylone and MDMA in female rats.
Neuropharmacology. 2015 May; 92:90-7.N

Abstract

Male rats will intravenously self-administer (IVSA) the substituted cathinone stimulants ("bath salts") mephedrone (4-methylmethcathione) and methylone (3,4-methylenedioxymethcathinone) robustly, whereas the IVSA of 3,4-methylenedioxymethamphetamine (MDMA) is inconsistent in many rat models. There are no data available on the self-administration of these drugs in female rats, thus a study was undertaken to contrast them directly. Groups of female Wistar rats were trained to self-administer mephedrone, methylone or MDMA (0.5 mg/kg/inf) under a Fixed-Ratio (FR) 1 schedule of reinforcement for 14 sessions. Following the acquisition interval, animals were evaluated in FR (0.0, 0.125, 0.25, 0.5, 1.0, 2.5 mg/kg/inf) and PR (0.125, 1.0 mg/kg/inf) dose-substitution procedures. The results show that female rats acquired the self-administration of all three compounds with intakes in mephedrone-trained rats that were significantly higher than that of methylone-trained or MDMA-trained rats. In dose-substitution under either FR or PR contingencies, however, the potencies of all three drugs were similar within the original training groups. The mephedrone-trained animals exhibited higher intakes of all drugs during dose-substitution, indicating lasting consequences of the training drug. Abuse liability of these three compounds is therefore predicted to be similar in established stimulant users but may differ in liability if they are primary drugs of initiation.

Authors+Show Affiliations

Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA.Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA.Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA. Electronic address: mtaffe@scripps.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

25600245

Citation

Creehan, Kevin M., et al. "Intravenous Self-administration of Mephedrone, Methylone and MDMA in Female Rats." Neuropharmacology, vol. 92, 2015, pp. 90-7.
Creehan KM, Vandewater SA, Taffe MA. Intravenous self-administration of mephedrone, methylone and MDMA in female rats. Neuropharmacology. 2015;92:90-7.
Creehan, K. M., Vandewater, S. A., & Taffe, M. A. (2015). Intravenous self-administration of mephedrone, methylone and MDMA in female rats. Neuropharmacology, 92, 90-7. https://doi.org/10.1016/j.neuropharm.2015.01.003
Creehan KM, Vandewater SA, Taffe MA. Intravenous Self-administration of Mephedrone, Methylone and MDMA in Female Rats. Neuropharmacology. 2015;92:90-7. PubMed PMID: 25600245.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intravenous self-administration of mephedrone, methylone and MDMA in female rats. AU - Creehan,Kevin M, AU - Vandewater,Sophia A, AU - Taffe,Michael A, Y1 - 2015/01/17/ PY - 2014/11/13/received PY - 2015/01/06/revised PY - 2015/01/07/accepted PY - 2015/1/21/entrez PY - 2015/1/21/pubmed PY - 2015/12/15/medline KW - 3,4-methylenedioxymethamphetamine (PubChem CID:1615) KW - 4-methylmethcathinone (PubChemCID: 45266826) KW - Bath salts KW - Drug addiction KW - Ecstasy KW - Reward KW - Substance abuse KW - methylone (PubChem CID: 45789647) SP - 90 EP - 7 JF - Neuropharmacology JO - Neuropharmacology VL - 92 N2 - Male rats will intravenously self-administer (IVSA) the substituted cathinone stimulants ("bath salts") mephedrone (4-methylmethcathione) and methylone (3,4-methylenedioxymethcathinone) robustly, whereas the IVSA of 3,4-methylenedioxymethamphetamine (MDMA) is inconsistent in many rat models. There are no data available on the self-administration of these drugs in female rats, thus a study was undertaken to contrast them directly. Groups of female Wistar rats were trained to self-administer mephedrone, methylone or MDMA (0.5 mg/kg/inf) under a Fixed-Ratio (FR) 1 schedule of reinforcement for 14 sessions. Following the acquisition interval, animals were evaluated in FR (0.0, 0.125, 0.25, 0.5, 1.0, 2.5 mg/kg/inf) and PR (0.125, 1.0 mg/kg/inf) dose-substitution procedures. The results show that female rats acquired the self-administration of all three compounds with intakes in mephedrone-trained rats that were significantly higher than that of methylone-trained or MDMA-trained rats. In dose-substitution under either FR or PR contingencies, however, the potencies of all three drugs were similar within the original training groups. The mephedrone-trained animals exhibited higher intakes of all drugs during dose-substitution, indicating lasting consequences of the training drug. Abuse liability of these three compounds is therefore predicted to be similar in established stimulant users but may differ in liability if they are primary drugs of initiation. SN - 1873-7064 UR - https://www.unboundmedicine.com/medline/citation/25600245/Intravenous_self_administration_of_mephedrone_methylone_and_MDMA_in_female_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028-3908(15)00010-6 DB - PRIME DP - Unbound Medicine ER -