Tags

Type your tag names separated by a space and hit enter

Increase of Framingham cardiovascular disease risk score is associated with severity of lower urinary tract symptoms.
BJU Int. 2015 Nov; 116(5):791-6.BI

Abstract

OBJECTIVE

To determine the relationship between lower urinary tract symptoms (LUTS)/benign prostatic hyperplasia (BPH) and 10-year risk of cardiovascular disease (CVD) assessed by the Framingham CVD risk score in a cohort of patients without previous episodes of stroke and/or acute myocardial infarction.

PATIENTS AND METHODS

From September 2010 to September 2014, 336 consecutive patients with BPH-related LUTS were prospectively enrolled. The general 10-year Framingham CVD risk score, expressed as percentage and assessing the risk of atherosclerotic CVD events, was calculated for each patient. Individuals with low risk had ≤10% CVD risk at 10 years, with intermediate risk 10-20% and with high risk ≥20%. Logistic regression analyses were used to identify variables for predicting a Framingham CVD risk score of ≥10% and moderate-severe LUTS (International Prostate Symptom Score [IPSS] ≥8), adjusted for confounding factors.

RESULTS

As category of Framingham CVD risk score increased, we observed higher IPSS (18.0 vs 18.50 vs 19.0; P < 0.05), high IPSS-voiding (6.0 vs 9.0 vs 9.5; P < 0.05) and worse sexual function. Prostate volume significantly increased in those with intermediate- vs low-risk scores (54.5 vs 44.1 mL; P < 0.05). Multivariate logistic regression analysis showed that intermediate- [odds ratio (OR) 8.65; P < 0.01) and high-risk scores (OR 1.79; P < 0.05) were independently associated with moderate-severe LUTS. At age-adjusted logistic regression analysis, moderate-severe LUTS was independently associated with Framingham CVD risk score of ≥10% (OR 5.91; P < 0.05).

CONCLUSION

Our cross-sectional study in a cohort of patients with LUTS-BPH showed an increase of more than five-fold of having a Framingham CVD risk score of ≥10% in men with moderate-severe LUTS.

Authors+Show Affiliations

Department of Urology, Section of Endocrinology, Andrology and Internal Medicine, University of Catania, Catania, Italy.Department of Urology, Section of Endocrinology, Andrology and Internal Medicine, University of Catania, Catania, Italy.Department of Urology, Section of Endocrinology, Andrology and Internal Medicine, University of Catania, Catania, Italy.Department of Urology, Section of Endocrinology, Andrology and Internal Medicine, University of Catania, Catania, Italy.Department of Urology, Section of Endocrinology, Andrology and Internal Medicine, University of Catania, Catania, Italy.Department of Urology, Section of Endocrinology, Andrology and Internal Medicine, University of Catania, Catania, Italy.Department of Urology, Section of Endocrinology, Andrology and Internal Medicine, University of Catania, Catania, Italy.Department of Medical and Paediatric Sciences, Section of Endocrinology, Andrology and Internal Medicine, University of Catania, Catania, Italy.Department of Medical and Paediatric Sciences, Section of Endocrinology, Andrology and Internal Medicine, University of Catania, Catania, Italy.Department of Medical and Paediatric Sciences, Section of Endocrinology, Andrology and Internal Medicine, University of Catania, Catania, Italy.Department of Urology, Section of Endocrinology, Andrology and Internal Medicine, University of Catania, Catania, Italy.Department of Urology, Section of Endocrinology, Andrology and Internal Medicine, University of Catania, Catania, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25601421

Citation

Russo, Giorgio I., et al. "Increase of Framingham Cardiovascular Disease Risk Score Is Associated With Severity of Lower Urinary Tract Symptoms." BJU International, vol. 116, no. 5, 2015, pp. 791-6.
Russo GI, Castelli T, Privitera S, et al. Increase of Framingham cardiovascular disease risk score is associated with severity of lower urinary tract symptoms. BJU Int. 2015;116(5):791-6.
Russo, G. I., Castelli, T., Privitera, S., Fragalà, E., Favilla, V., Reale, G., Urzì, D., La Vignera, S., Condorelli, R. A., Calogero, A. E., Cimino, S., & Morgia, G. (2015). Increase of Framingham cardiovascular disease risk score is associated with severity of lower urinary tract symptoms. BJU International, 116(5), 791-6. https://doi.org/10.1111/bju.13053
Russo GI, et al. Increase of Framingham Cardiovascular Disease Risk Score Is Associated With Severity of Lower Urinary Tract Symptoms. BJU Int. 2015;116(5):791-6. PubMed PMID: 25601421.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increase of Framingham cardiovascular disease risk score is associated with severity of lower urinary tract symptoms. AU - Russo,Giorgio I, AU - Castelli,Tommaso, AU - Privitera,Salvatore, AU - Fragalà,Eugenia, AU - Favilla,Vincenzo, AU - Reale,Giulio, AU - Urzì,Daniele, AU - La Vignera,Sandro, AU - Condorelli,Rosita A, AU - Calogero,Aldo E, AU - Cimino,Sebastiano, AU - Morgia,Giuseppe, Y1 - 2015/03/25/ PY - 2015/1/21/entrez PY - 2015/1/21/pubmed PY - 2016/1/27/medline KW - Framingham score KW - LUTS KW - benign prostatic obstruction KW - cardiovascular disease KW - metabolic syndrome KW - prostate SP - 791 EP - 6 JF - BJU international JO - BJU Int VL - 116 IS - 5 N2 - OBJECTIVE: To determine the relationship between lower urinary tract symptoms (LUTS)/benign prostatic hyperplasia (BPH) and 10-year risk of cardiovascular disease (CVD) assessed by the Framingham CVD risk score in a cohort of patients without previous episodes of stroke and/or acute myocardial infarction. PATIENTS AND METHODS: From September 2010 to September 2014, 336 consecutive patients with BPH-related LUTS were prospectively enrolled. The general 10-year Framingham CVD risk score, expressed as percentage and assessing the risk of atherosclerotic CVD events, was calculated for each patient. Individuals with low risk had ≤10% CVD risk at 10 years, with intermediate risk 10-20% and with high risk ≥20%. Logistic regression analyses were used to identify variables for predicting a Framingham CVD risk score of ≥10% and moderate-severe LUTS (International Prostate Symptom Score [IPSS] ≥8), adjusted for confounding factors. RESULTS: As category of Framingham CVD risk score increased, we observed higher IPSS (18.0 vs 18.50 vs 19.0; P < 0.05), high IPSS-voiding (6.0 vs 9.0 vs 9.5; P < 0.05) and worse sexual function. Prostate volume significantly increased in those with intermediate- vs low-risk scores (54.5 vs 44.1 mL; P < 0.05). Multivariate logistic regression analysis showed that intermediate- [odds ratio (OR) 8.65; P < 0.01) and high-risk scores (OR 1.79; P < 0.05) were independently associated with moderate-severe LUTS. At age-adjusted logistic regression analysis, moderate-severe LUTS was independently associated with Framingham CVD risk score of ≥10% (OR 5.91; P < 0.05). CONCLUSION: Our cross-sectional study in a cohort of patients with LUTS-BPH showed an increase of more than five-fold of having a Framingham CVD risk score of ≥10% in men with moderate-severe LUTS. SN - 1464-410X UR - https://www.unboundmedicine.com/medline/citation/25601421/Increase_of_Framingham_cardiovascular_disease_risk_score_is_associated_with_severity_of_lower_urinary_tract_symptoms_ L2 - https://doi.org/10.1111/bju.13053 DB - PRIME DP - Unbound Medicine ER -