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Age dependent levels of plasma homocysteine and cognitive performance.
Behav Brain Res. 2015 Apr 15; 283:139-44.BB

Abstract

Elevated plasma homocysteine (hcy) levels, also known as hyperhomocysteinemia (hhcy), have been associated with cognitive impairment and neurodegenerative disorders. Hhcy has been attributed to deficiency of B vitamins which can adversely affect the brain and result in memory loss and poor attention power. Monitoring hcy levels and the use of vitamin supplementation to treat hhcy may therefore prove advantageous for the prevention and management of cognitive impairment. With this in consideration, we measured plasma hcy, folate and vitamin B12 levels in 639 subjects from different age groups in two sub-regions of India. Cognitive function was also measured using attention span and immediate and delayed memory recall tests. Depression scores were obtained using the Beck Depression Inventory-II and functional impairment was assessed using the functional activities questionnaire (FAQ) score. As hhcy has also been linked to inflammation, plasma levels of high sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6) were also measured. The results demonstrated significant negative correlations between hcy levels and folic acid levels, vitamin B12 levels and cognitive performance (attention span and delayed but not immediate memory recall) along with significant positive correlations between hcy levels and depression scores and hsCRP (but not IL-6) levels. A positive correlation was also observed between hcy levels and FAQ scores, however this was not found to be significant. Based on these results, folic acid and vitamin B12 intervention in people with elevated hcy levels in India could prove to be effective in lowering hcy levels and help maintain or improve cognitive function.

Authors+Show Affiliations

Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.Interdisciplinary School of Indian System of Medicine, SRM University, Katankulathur, Chennai, India.Arvind Remedies Ltd., Chennai, India.Arvind Remedies Ltd., Chennai, India.Adesh University, Barnala Road, Bathinda, Punjab, India.Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India; Interdisciplinary School of Indian System of Medicine, SRM University, Katankulathur, Chennai, India; Arvind Remedies Ltd., Chennai, India; Adesh University, Barnala Road, Bathinda, Punjab, India. Electronic address: rinkiv3@gmail.com.Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25601573

Citation

Agrawal, Aruna, et al. "Age Dependent Levels of Plasma Homocysteine and Cognitive Performance." Behavioural Brain Research, vol. 283, 2015, pp. 139-44.
Agrawal A, Ilango K, Singh PK, et al. Age dependent levels of plasma homocysteine and cognitive performance. Behav Brain Res. 2015;283:139-44.
Agrawal, A., Ilango, K., Singh, P. K., Karmakar, D., Singh, G. P., Kumari, R., & Dubey, G. P. (2015). Age dependent levels of plasma homocysteine and cognitive performance. Behavioural Brain Research, 283, 139-44. https://doi.org/10.1016/j.bbr.2015.01.016
Agrawal A, et al. Age Dependent Levels of Plasma Homocysteine and Cognitive Performance. Behav Brain Res. 2015 Apr 15;283:139-44. PubMed PMID: 25601573.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age dependent levels of plasma homocysteine and cognitive performance. AU - Agrawal,Aruna, AU - Ilango,K, AU - Singh,Praveen K, AU - Karmakar,Dipankar, AU - Singh,G P I, AU - Kumari,Rinki, AU - Dubey,G P, Y1 - 2015/01/16/ PY - 2014/11/13/received PY - 2015/01/07/revised PY - 2015/01/09/accepted PY - 2015/1/21/entrez PY - 2015/1/21/pubmed PY - 2015/12/15/medline KW - Cognition KW - Folate KW - Homocysteine KW - Interleukin-6 KW - Vitamin B12 SP - 139 EP - 44 JF - Behavioural brain research JO - Behav. Brain Res. VL - 283 N2 - Elevated plasma homocysteine (hcy) levels, also known as hyperhomocysteinemia (hhcy), have been associated with cognitive impairment and neurodegenerative disorders. Hhcy has been attributed to deficiency of B vitamins which can adversely affect the brain and result in memory loss and poor attention power. Monitoring hcy levels and the use of vitamin supplementation to treat hhcy may therefore prove advantageous for the prevention and management of cognitive impairment. With this in consideration, we measured plasma hcy, folate and vitamin B12 levels in 639 subjects from different age groups in two sub-regions of India. Cognitive function was also measured using attention span and immediate and delayed memory recall tests. Depression scores were obtained using the Beck Depression Inventory-II and functional impairment was assessed using the functional activities questionnaire (FAQ) score. As hhcy has also been linked to inflammation, plasma levels of high sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6) were also measured. The results demonstrated significant negative correlations between hcy levels and folic acid levels, vitamin B12 levels and cognitive performance (attention span and delayed but not immediate memory recall) along with significant positive correlations between hcy levels and depression scores and hsCRP (but not IL-6) levels. A positive correlation was also observed between hcy levels and FAQ scores, however this was not found to be significant. Based on these results, folic acid and vitamin B12 intervention in people with elevated hcy levels in India could prove to be effective in lowering hcy levels and help maintain or improve cognitive function. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/25601573/Age_dependent_levels_of_plasma_homocysteine_and_cognitive_performance_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(15)00020-0 DB - PRIME DP - Unbound Medicine ER -