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Cardiac biomarkers in systemic sclerosis: contribution of high-sensitivity cardiac troponin in addition to N-terminal pro-brain natriuretic peptide.
Arthritis Care Res (Hoboken). 2015 Jul; 67(7):1022-30.AC

Abstract

OBJECTIVE

To measure plasma concentrations of high-sensitivity cardiac troponin T (HS-cTnT) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with systemic sclerosis (SSc; scleroderma) and age- and sex-matched healthy control subjects, and to examine the contribution of traditional cardiovascular risk factors and SSc features to the concentrations of these 2 cardiac biomarkers.

METHODS

Plasma HS-cTnT and NT-proBNP concentrations were measured using the electrochemiluminescence method and sandwich immunoassay, respectively.

RESULTS

The study group comprised 161 unrelated patients with SSc and 213 matched control subjects. HS-cTnT and NT-proBNP plasma levels were significantly increased in SSc patients compared with controls (both P < 0.001). Similar results were observed in the subgroup of patients with SSc who had no cardiovascular risk factors (n = 72). Multivariate logistic regression analysis confirmed diabetes mellitus (P = 0.006), high blood pressure (P = 0.021), precapillary pulmonary hypertension (P = 0.039), and the diffuse cutaneous SSc (P = 0.004) as factors independently associated with an HS-cTnT level of >14 ng/liter. Increased NT-proBNP concentrations were associated only with the presence of precapillary pulmonary hypertension (P < 0.001). Normal concentrations of both HS-cTnT and NT-proBNP had a high negative predictive value for precapillary pulmonary hypertension (92%), and the combination of increased values of these 2 markers had the highest strength of association with precapillary pulmonary hypertension in logistic regression analysis.

CONCLUSION

HS-cTnT and NT-proBNP concentrations are increased in patients with SSc, even in those who are free of cardiovascular risk factors. These easily obtained biomarkers may be useful for systematic evaluation and stratification of SSc patients, especially to identify those at risk of pulmonary hypertension.

Authors+Show Affiliations

Paris Descartes University, Sorbonne Paris Cité, Cochin Hospital, and Paris Descartes University, INSERM U1016 and CNRS UMR8104, Cochin Institute, Paris, France.Paris 13 University, University Hospital of Paris-Seine-Saint-Denis, Bobigny, France and UMR 942, Paris, France.Cochin and Hôtel-Dieu Hospitals, Paris, France.Cochin and Hôtel-Dieu Hospitals, Paris, France.Tenon Hospital, Paris, France.Paris Descartes University, Sorbonne Paris Cité, Cochin Hospital, Paris, France.Paris Descartes University, Sorbonne Paris Cité, Cochin Hospital, and Paris Descartes University, INSERM U1016 and CNRS UMR8104, Cochin Institute, Paris, France.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25604469

Citation

Avouac, Jérôme, et al. "Cardiac Biomarkers in Systemic Sclerosis: Contribution of High-sensitivity Cardiac Troponin in Addition to N-terminal Pro-brain Natriuretic Peptide." Arthritis Care & Research, vol. 67, no. 7, 2015, pp. 1022-30.
Avouac J, Meune C, Chenevier-Gobeaux C, et al. Cardiac biomarkers in systemic sclerosis: contribution of high-sensitivity cardiac troponin in addition to N-terminal pro-brain natriuretic peptide. Arthritis Care Res (Hoboken). 2015;67(7):1022-30.
Avouac, J., Meune, C., Chenevier-Gobeaux, C., Borderie, D., Lefevre, G., Kahan, A., & Allanore, Y. (2015). Cardiac biomarkers in systemic sclerosis: contribution of high-sensitivity cardiac troponin in addition to N-terminal pro-brain natriuretic peptide. Arthritis Care & Research, 67(7), 1022-30. https://doi.org/10.1002/acr.22547
Avouac J, et al. Cardiac Biomarkers in Systemic Sclerosis: Contribution of High-sensitivity Cardiac Troponin in Addition to N-terminal Pro-brain Natriuretic Peptide. Arthritis Care Res (Hoboken). 2015;67(7):1022-30. PubMed PMID: 25604469.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiac biomarkers in systemic sclerosis: contribution of high-sensitivity cardiac troponin in addition to N-terminal pro-brain natriuretic peptide. AU - Avouac,Jérôme, AU - Meune,Christophe, AU - Chenevier-Gobeaux,Camille, AU - Borderie,Didier, AU - Lefevre,Guillaume, AU - Kahan,André, AU - Allanore,Yannick, PY - 2014/04/04/received PY - 2014/12/15/revised PY - 2015/01/06/accepted PY - 2015/1/22/entrez PY - 2015/1/22/pubmed PY - 2015/9/10/medline SP - 1022 EP - 30 JF - Arthritis care & research JO - Arthritis Care Res (Hoboken) VL - 67 IS - 7 N2 - OBJECTIVE: To measure plasma concentrations of high-sensitivity cardiac troponin T (HS-cTnT) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with systemic sclerosis (SSc; scleroderma) and age- and sex-matched healthy control subjects, and to examine the contribution of traditional cardiovascular risk factors and SSc features to the concentrations of these 2 cardiac biomarkers. METHODS: Plasma HS-cTnT and NT-proBNP concentrations were measured using the electrochemiluminescence method and sandwich immunoassay, respectively. RESULTS: The study group comprised 161 unrelated patients with SSc and 213 matched control subjects. HS-cTnT and NT-proBNP plasma levels were significantly increased in SSc patients compared with controls (both P < 0.001). Similar results were observed in the subgroup of patients with SSc who had no cardiovascular risk factors (n = 72). Multivariate logistic regression analysis confirmed diabetes mellitus (P = 0.006), high blood pressure (P = 0.021), precapillary pulmonary hypertension (P = 0.039), and the diffuse cutaneous SSc (P = 0.004) as factors independently associated with an HS-cTnT level of >14 ng/liter. Increased NT-proBNP concentrations were associated only with the presence of precapillary pulmonary hypertension (P < 0.001). Normal concentrations of both HS-cTnT and NT-proBNP had a high negative predictive value for precapillary pulmonary hypertension (92%), and the combination of increased values of these 2 markers had the highest strength of association with precapillary pulmonary hypertension in logistic regression analysis. CONCLUSION: HS-cTnT and NT-proBNP concentrations are increased in patients with SSc, even in those who are free of cardiovascular risk factors. These easily obtained biomarkers may be useful for systematic evaluation and stratification of SSc patients, especially to identify those at risk of pulmonary hypertension. SN - 2151-4658 UR - https://www.unboundmedicine.com/medline/citation/25604469/Cardiac_biomarkers_in_systemic_sclerosis:_contribution_of_high_sensitivity_cardiac_troponin_in_addition_to_N_terminal_pro_brain_natriuretic_peptide_ L2 - https://doi.org/10.1002/acr.22547 DB - PRIME DP - Unbound Medicine ER -