Tags

Type your tag names separated by a space and hit enter

Convergent evolution of ribonuclease h in LTR retrotransposons and retroviruses.
Mol Biol Evol. 2015 May; 32(5):1197-207.MB

Abstract

Ty3/Gypsy long terminals repeat (LTR) retrotransposons are structurally and phylogenetically close to retroviruses. Two notable structural differences between these groups of genetic elements are 1) the presence in retroviruses of an additional envelope gene, env, which mediates infection, and 2) a specific dual ribonuclease H (RNH) domain encoded by the retroviral pol gene. However, similar to retroviruses, many Ty3/Gypsy LTR retrotransposons harbor additional env-like genes, promoting concepts of the infective mode of these retrotransposons. Here, we provide a further line of evidence of similarity between retroviruses and some Ty3/Gypsy LTR retrotransposons. We identify that, together with their additional genes, plant Ty3/Gypsy LTR retrotransposons of the Tat group have a second RNH, as do retroviruses. Most importantly, we show that the resulting dual RNHs of Tat LTR retrotransposons and retroviruses emerged independently, providing strong evidence for their convergent evolution. The convergent resemblance of Tat LTR retrotransposons and retroviruses may indicate similar selection pressures acting on these diverse groups of elements and reveal potential evolutionary constraints on their structure. We speculate that dual RNH is required to accelerate retrotransposon evolution through increased rates of strand transfer events and subsequent recombination events.

Authors+Show Affiliations

Laboratory of Molecular Genetic Systems, Institute of Cytology and Genetics, Novosibirsk, Russia.Department of Biological Sciences and RNA Institute, University at Albany.Laboratory of Molecular Genetic Systems, Institute of Cytology and Genetics, Novosibirsk, Russia.Laboratory of Molecular Genetic Systems, Institute of Cytology and Genetics, Novosibirsk, Russia Department of Natural Sciences, Novosibirsk State University, Novosibirsk, Russia g.smyshl@gmail.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25605791

Citation

Ustyantsev, Kirill, et al. "Convergent Evolution of Ribonuclease H in LTR Retrotransposons and Retroviruses." Molecular Biology and Evolution, vol. 32, no. 5, 2015, pp. 1197-207.
Ustyantsev K, Novikova O, Blinov A, et al. Convergent evolution of ribonuclease h in LTR retrotransposons and retroviruses. Mol Biol Evol. 2015;32(5):1197-207.
Ustyantsev, K., Novikova, O., Blinov, A., & Smyshlyaev, G. (2015). Convergent evolution of ribonuclease h in LTR retrotransposons and retroviruses. Molecular Biology and Evolution, 32(5), 1197-207. https://doi.org/10.1093/molbev/msv008
Ustyantsev K, et al. Convergent Evolution of Ribonuclease H in LTR Retrotransposons and Retroviruses. Mol Biol Evol. 2015;32(5):1197-207. PubMed PMID: 25605791.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Convergent evolution of ribonuclease h in LTR retrotransposons and retroviruses. AU - Ustyantsev,Kirill, AU - Novikova,Olga, AU - Blinov,Alexander, AU - Smyshlyaev,Georgy, Y1 - 2015/01/19/ PY - 2015/1/22/entrez PY - 2015/1/22/pubmed PY - 2016/1/26/medline KW - LTR retrotransposons KW - convergent evolution KW - retroviruses KW - ribonuclease H SP - 1197 EP - 207 JF - Molecular biology and evolution JO - Mol Biol Evol VL - 32 IS - 5 N2 - Ty3/Gypsy long terminals repeat (LTR) retrotransposons are structurally and phylogenetically close to retroviruses. Two notable structural differences between these groups of genetic elements are 1) the presence in retroviruses of an additional envelope gene, env, which mediates infection, and 2) a specific dual ribonuclease H (RNH) domain encoded by the retroviral pol gene. However, similar to retroviruses, many Ty3/Gypsy LTR retrotransposons harbor additional env-like genes, promoting concepts of the infective mode of these retrotransposons. Here, we provide a further line of evidence of similarity between retroviruses and some Ty3/Gypsy LTR retrotransposons. We identify that, together with their additional genes, plant Ty3/Gypsy LTR retrotransposons of the Tat group have a second RNH, as do retroviruses. Most importantly, we show that the resulting dual RNHs of Tat LTR retrotransposons and retroviruses emerged independently, providing strong evidence for their convergent evolution. The convergent resemblance of Tat LTR retrotransposons and retroviruses may indicate similar selection pressures acting on these diverse groups of elements and reveal potential evolutionary constraints on their structure. We speculate that dual RNH is required to accelerate retrotransposon evolution through increased rates of strand transfer events and subsequent recombination events. SN - 1537-1719 UR - https://www.unboundmedicine.com/medline/citation/25605791/Convergent_evolution_of_ribonuclease_h_in_LTR_retrotransposons_and_retroviruses_ L2 - https://academic.oup.com/mbe/article-lookup/doi/10.1093/molbev/msv008 DB - PRIME DP - Unbound Medicine ER -