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Placebo and nocebo effects in the neurological practice.
Arq Neuropsiquiatr. 2015 Jan; 73(1):58-63.AN

Abstract

Knowledge of placebo and nocebo effects is essential to identify their influence on the results in clinical practice and clinical trials, and thereby properly interpret their results. It is known that the gold standard of clinical trials research is the double-blind, placebo-controlled, randomized clinical study. The objective of this review is to distinguish specific from non-specific effects, so that the presence of positive effects in the group that received placebo (placebo effect) and the presence of adverse effects in the group receiving placebo (nocebo effect) lead to confounding in interpreting the results. Placebo and nocebo effects have been considered in neurological diseases such as depression, pain, headache, multiple sclerosis, epilepsy. As placebo and nocebo effects are also present in clinical practice, the purpose of this review is to draw attention to their influence on neurological practice, calling attention to the development of measures that can minimize them.

Authors+Show Affiliations

Departamento de Neurologia, Hospital Universitário Antonio Pedro, Universidade Federal Fluminense, Niterói, RJ, Brazil.Departamento de Neurologia, Hospital Universitário Antonio Pedro, Universidade Federal Fluminense, Niterói, RJ, Brazil.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25608129

Citation

Bittar, Caroline, and Osvaldo J M. Nascimento. "Placebo and Nocebo Effects in the Neurological Practice." Arquivos De Neuro-psiquiatria, vol. 73, no. 1, 2015, pp. 58-63.
Bittar C, Nascimento OJ. Placebo and nocebo effects in the neurological practice. Arq Neuropsiquiatr. 2015;73(1):58-63.
Bittar, C., & Nascimento, O. J. (2015). Placebo and nocebo effects in the neurological practice. Arquivos De Neuro-psiquiatria, 73(1), 58-63. https://doi.org/10.1590/0004-282X20140180
Bittar C, Nascimento OJ. Placebo and Nocebo Effects in the Neurological Practice. Arq Neuropsiquiatr. 2015;73(1):58-63. PubMed PMID: 25608129.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Placebo and nocebo effects in the neurological practice. AU - Bittar,Caroline, AU - Nascimento,Osvaldo J M, Y1 - 2015/01/01/ PY - 2014/07/14/received PY - 2014/09/10/accepted PY - 2015/1/22/entrez PY - 2015/1/22/pubmed PY - 2015/6/20/medline SP - 58 EP - 63 JF - Arquivos de neuro-psiquiatria JO - Arq Neuropsiquiatr VL - 73 IS - 1 N2 - Knowledge of placebo and nocebo effects is essential to identify their influence on the results in clinical practice and clinical trials, and thereby properly interpret their results. It is known that the gold standard of clinical trials research is the double-blind, placebo-controlled, randomized clinical study. The objective of this review is to distinguish specific from non-specific effects, so that the presence of positive effects in the group that received placebo (placebo effect) and the presence of adverse effects in the group receiving placebo (nocebo effect) lead to confounding in interpreting the results. Placebo and nocebo effects have been considered in neurological diseases such as depression, pain, headache, multiple sclerosis, epilepsy. As placebo and nocebo effects are also present in clinical practice, the purpose of this review is to draw attention to their influence on neurological practice, calling attention to the development of measures that can minimize them. SN - 1678-4227 UR - https://www.unboundmedicine.com/medline/citation/25608129/Placebo_and_nocebo_effects_in_the_neurological_practice_ L2 - http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000100058&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -