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Multi-modal MRI of mild traumatic brain injury.
Neuroimage Clin 2015; 7:87-97NC

Abstract

Multi-modal magnetic resonance imaging (MRI) that included high resolution structural imaging, diffusion tensor imaging (DTI), magnetization transfer ratio (MTR) imaging, and magnetic resonance spectroscopic imaging (MRSI) were performed in mild traumatic brain injury (mTBI) patients with negative computed tomographic scans and in an orthopedic-injured (OI) group without concomitant injury to the brain. The OI group served as a comparison group for mTBI. MRI scans were performed both in the acute phase of injury (~24 h) and at follow-up (~90 days). DTI data was analyzed using tract based spatial statistics (TBSS). Global and regional atrophies were calculated using tensor-based morphometry (TBM). MTR values were calculated using the standard method. MRSI was analyzed using LC Model. At the initial scan, the mean diffusivity (MD) was significantly higher in the mTBI cohort relative to the comparison group in several white matter (WM) regions that included internal capsule, external capsule, superior corona radiata, anterior corona radiata, posterior corona radiata, inferior fronto-occipital fasciculus, inferior longitudinal fasciculus, forceps major and forceps minor of the corpus callosum, superior longitudinal fasciculus, and corticospinal tract in the right hemisphere. TBSS analysis failed to detect significant differences in any DTI measures between the initial and follow-up scans either in the mTBI or OI group. No significant differences were found in MRSI, MTR or morphometry between the mTBI and OI cohorts either at the initial or follow-up scans with or without family wise error (FWE) correction. Our study suggests that a number of WM tracts are affected in mTBI in the acute phase of injury and that these changes disappear by 90 days. This study also suggests that none of the MRI-modalities used in this study, with the exception of DTI, is sensitive in detecting changes in the acute phase of mTBI.

Authors+Show Affiliations

Diagnostic and Interventional Imaging, University of Texas Health Science Center at Houston, Houston, TX, USA.Diagnostic and Interventional Imaging, University of Texas Health Science Center at Houston, Houston, TX, USA.Diagnostic and Interventional Imaging, University of Texas Health Science Center at Houston, Houston, TX, USA.Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA ; Radiology, Baylor College of Medicine, Houston, TX, USA.Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA ; Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA.Radiology, Baylor College of Medicine, Houston, TX, USA.Neurosurgery, Baylor College of Medicine, Houston, TX, USA.Diagnostic and Interventional Imaging, University of Texas Health Science Center at Houston, Houston, TX, USA.Neurosurgery, Baylor College of Medicine, Houston, TX, USA.Emergency Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

25610770

Citation

Narayana, Ponnada A., et al. "Multi-modal MRI of Mild Traumatic Brain Injury." NeuroImage. Clinical, vol. 7, 2015, pp. 87-97.
Narayana PA, Yu X, Hasan KM, et al. Multi-modal MRI of mild traumatic brain injury. Neuroimage Clin. 2015;7:87-97.
Narayana, P. A., Yu, X., Hasan, K. M., Wilde, E. A., Levin, H. S., Hunter, J. V., ... McCarthy, J. J. (2015). Multi-modal MRI of mild traumatic brain injury. NeuroImage. Clinical, 7, pp. 87-97. doi:10.1016/j.nicl.2014.07.010.
Narayana PA, et al. Multi-modal MRI of Mild Traumatic Brain Injury. Neuroimage Clin. 2015;7:87-97. PubMed PMID: 25610770.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multi-modal MRI of mild traumatic brain injury. AU - Narayana,Ponnada A, AU - Yu,Xintian, AU - Hasan,Khader M, AU - Wilde,Elisabeth A, AU - Levin,Harvey S, AU - Hunter,Jill V, AU - Miller,Emmy R, AU - Patel,Vipul Kumar S, AU - Robertson,Claudia S, AU - McCarthy,James J, Y1 - 2014/07/24/ PY - 2014/05/09/received PY - 2014/07/20/revised PY - 2014/07/22/accepted PY - 2015/1/23/entrez PY - 2015/1/23/pubmed PY - 2015/9/25/medline KW - Diffusion tensor imaging KW - Magnetic resonance imaging KW - Magnetic resonance spectroscopic imaging KW - Magnetization transfer ratio KW - Mild traumatic brain injury KW - Orthopedic injury KW - Tensor based morphometry KW - acr, anterior region of corona radiata KW - alic, anterior limb of internal capsule KW - cc, corpus callosum KW - cg, cingulate gyrus KW - cs, centrum semiovale KW - cst, corticospinal tract KW - ec, external capsule KW - ic, internal capsule KW - ifo, inferior fronto-occipital fasciculus KW - ilf, inferior longitudinal fasciculus KW - jlc, juxtapositional lobule cortex KW - mfg, superior frontal gyrus KW - pcg, paracingulate gyrus KW - pcr, posterior region of corona radiata KW - plic, posterior limb of internal capsule KW - scr, superior region of corona radiata KW - sfg, superior frontal gyrus KW - sfo, superior fronto-occipital fasciculus KW - slf, superior longitudinal fasciculus SP - 87 EP - 97 JF - NeuroImage. Clinical JO - Neuroimage Clin VL - 7 N2 - Multi-modal magnetic resonance imaging (MRI) that included high resolution structural imaging, diffusion tensor imaging (DTI), magnetization transfer ratio (MTR) imaging, and magnetic resonance spectroscopic imaging (MRSI) were performed in mild traumatic brain injury (mTBI) patients with negative computed tomographic scans and in an orthopedic-injured (OI) group without concomitant injury to the brain. The OI group served as a comparison group for mTBI. MRI scans were performed both in the acute phase of injury (~24 h) and at follow-up (~90 days). DTI data was analyzed using tract based spatial statistics (TBSS). Global and regional atrophies were calculated using tensor-based morphometry (TBM). MTR values were calculated using the standard method. MRSI was analyzed using LC Model. At the initial scan, the mean diffusivity (MD) was significantly higher in the mTBI cohort relative to the comparison group in several white matter (WM) regions that included internal capsule, external capsule, superior corona radiata, anterior corona radiata, posterior corona radiata, inferior fronto-occipital fasciculus, inferior longitudinal fasciculus, forceps major and forceps minor of the corpus callosum, superior longitudinal fasciculus, and corticospinal tract in the right hemisphere. TBSS analysis failed to detect significant differences in any DTI measures between the initial and follow-up scans either in the mTBI or OI group. No significant differences were found in MRSI, MTR or morphometry between the mTBI and OI cohorts either at the initial or follow-up scans with or without family wise error (FWE) correction. Our study suggests that a number of WM tracts are affected in mTBI in the acute phase of injury and that these changes disappear by 90 days. This study also suggests that none of the MRI-modalities used in this study, with the exception of DTI, is sensitive in detecting changes in the acute phase of mTBI. SN - 2213-1582 UR - https://www.unboundmedicine.com/medline/citation/25610770/Multi_modal_MRI_of_mild_traumatic_brain_injury_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2213-1582(14)00102-8 DB - PRIME DP - Unbound Medicine ER -