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Basal forebrain atrophy correlates with amyloid β burden in Alzheimer's disease.
Neuroimage Clin 2015; 7:105-13NC

Abstract

The brains of patients suffering from Alzheimer's disease (AD) have three classical pathological hallmarks: amyloid-beta (Aβ) plaques, tau tangles, and neurodegeneration, including that of cholinergic neurons of the basal forebrain. However the relationship between Aβ burden and basal forebrain degeneration has not been extensively studied. To investigate this association, basal forebrain volumes were determined from magnetic resonance images of controls, subjects with amnestic mild cognitive impairment (aMCI) and AD patients enrolled in the longitudinal Alzheimer's Disease Neuroimaging Initiative (ADNI) and Australian Imaging, Biomarkers and Lifestyle (AIBL) studies. In the AIBL cohort, these volumes were correlated within groups to neocortical gray matter retention of Pittsburgh compound B (PiB) from positron emission tomography images as a measure of Aβ load. The basal forebrain volumes of AD and aMCI subjects were significantly reduced compared to those of control subjects. Anterior basal forebrain volume was significantly correlated to neocortical PiB retention in AD subjects and aMCI subjects with high Aβ burden, whereas posterior basal forebrain volume was significantly correlated to neocortical PiB retention in control subjects with high Aβ burden. Therefore this study provides new evidence for a correlation between neocortical Aβ accumulation and basal forebrain degeneration. In addition, cluster analysis showed that subjects with a whole basal forebrain volume below a determined cut-off value had a 7 times higher risk of having a worse diagnosis within ~18 months.

Authors+Show Affiliations

Queensland Brain Institute, Clem Jones Centre for Ageing Dementia Research, The University of Queensland, Brisbane, Qld 4072, Australia.Commonwealth Scientific and Industrial Research Organisation, Computational Informatics, Brisbane, Qld 4029, Australia.Department of Nuclear Medicine and Centre for PET, Austin Health, Melbourne, Vic. 3084, Australia.Department of Nuclear Medicine and Centre for PET, Austin Health, Melbourne, Vic. 3084, Australia ; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Vic. 3084, Australia.Commonwealth Scientific and Industrial Research Organisation, Computational Informatics, Brisbane, Qld 4029, Australia.Commonwealth Scientific and Industrial Research Organisation, Computational Informatics, Brisbane, Qld 4029, Australia.Queensland Brain Institute, Clem Jones Centre for Ageing Dementia Research, The University of Queensland, Brisbane, Qld 4072, Australia.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25610772

Citation

Kerbler, Georg M., et al. "Basal Forebrain Atrophy Correlates With Amyloid Β Burden in Alzheimer's Disease." NeuroImage. Clinical, vol. 7, 2015, pp. 105-13.
Kerbler GM, Fripp J, Rowe CC, et al. Basal forebrain atrophy correlates with amyloid β burden in Alzheimer's disease. Neuroimage Clin. 2015;7:105-13.
Kerbler, G. M., Fripp, J., Rowe, C. C., Villemagne, V. L., Salvado, O., Rose, S., & Coulson, E. J. (2015). Basal forebrain atrophy correlates with amyloid β burden in Alzheimer's disease. NeuroImage. Clinical, 7, pp. 105-13. doi:10.1016/j.nicl.2014.11.015.
Kerbler GM, et al. Basal Forebrain Atrophy Correlates With Amyloid Β Burden in Alzheimer's Disease. Neuroimage Clin. 2015;7:105-13. PubMed PMID: 25610772.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Basal forebrain atrophy correlates with amyloid β burden in Alzheimer's disease. AU - Kerbler,Georg M, AU - Fripp,Jürgen, AU - Rowe,Christopher C, AU - Villemagne,Victor L, AU - Salvado,Olivier, AU - Rose,Stephen, AU - Coulson,Elizabeth J, AU - ,, Y1 - 2014/11/27/ PY - 2014/02/10/received PY - 2014/06/11/revised PY - 2014/11/18/accepted PY - 2015/1/23/entrez PY - 2015/1/23/pubmed PY - 2015/9/25/medline KW - 3D, 3-dimensional KW - AD, Alzheimer's disease KW - ADNI, Alzheimer's Disease Neuroimaging Initiative KW - AIBL, Australian Imaging, Biomarkers and Lifestyle Flagship Study of Aging KW - Alzheimer's disease KW - Amyloid KW - Aβ, amyloid-beta KW - Basal forebrain KW - CSF, cerebrospinal fluid KW - GM, gray matter KW - HC, healthy control KW - MCI, mild cognitive impairment KW - MNI, Montreal Neurological Institute KW - MPM, maximum probability maps KW - MPRAGE, magnetization prepared rapid gradient echo KW - MRI, magnetic resonance imaging KW - Magnetic resonance imaging KW - OR, odds ratio KW - PET KW - PET, positron emission tomography KW - PiB, Pittsburgh compound B KW - SPSS, statistics software package for the social sciences KW - SUVR, standard uptake value ratio KW - SyN, symmetric normalization KW - T1W, T1-weighted KW - TG-ROC, two-graph receiver operating characteristic KW - WM, white matter KW - aMCI, amnestic mild cognitive impairment SP - 105 EP - 13 JF - NeuroImage. Clinical JO - Neuroimage Clin VL - 7 N2 - The brains of patients suffering from Alzheimer's disease (AD) have three classical pathological hallmarks: amyloid-beta (Aβ) plaques, tau tangles, and neurodegeneration, including that of cholinergic neurons of the basal forebrain. However the relationship between Aβ burden and basal forebrain degeneration has not been extensively studied. To investigate this association, basal forebrain volumes were determined from magnetic resonance images of controls, subjects with amnestic mild cognitive impairment (aMCI) and AD patients enrolled in the longitudinal Alzheimer's Disease Neuroimaging Initiative (ADNI) and Australian Imaging, Biomarkers and Lifestyle (AIBL) studies. In the AIBL cohort, these volumes were correlated within groups to neocortical gray matter retention of Pittsburgh compound B (PiB) from positron emission tomography images as a measure of Aβ load. The basal forebrain volumes of AD and aMCI subjects were significantly reduced compared to those of control subjects. Anterior basal forebrain volume was significantly correlated to neocortical PiB retention in AD subjects and aMCI subjects with high Aβ burden, whereas posterior basal forebrain volume was significantly correlated to neocortical PiB retention in control subjects with high Aβ burden. Therefore this study provides new evidence for a correlation between neocortical Aβ accumulation and basal forebrain degeneration. In addition, cluster analysis showed that subjects with a whole basal forebrain volume below a determined cut-off value had a 7 times higher risk of having a worse diagnosis within ~18 months. SN - 2213-1582 UR - https://www.unboundmedicine.com/medline/citation/25610772/Basal_forebrain_atrophy_correlates_with_amyloid_β_burden_in_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2213-1582(14)00179-X DB - PRIME DP - Unbound Medicine ER -