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Clinical Significance of First-Trimester Screening of the Retronasal Triangle for Identification of Primary Cleft Palate.
Fetal Diagn Ther. 2015; 38(2):135-41.FD

Abstract

OBJECTIVE

To investigate the use of the retronasal triangle (RNT) for identification of orofacial cleft (OC) in the first trimester and the clinical application of three-dimensional (3D) ultrasound techniques for confirming the diagnosis of OC.

METHODS

A total of 5,054 women with singleton pregnancies underwent first-trimester screening for Down syndrome at 11-13(+6) weeks. The RNT was scanned in each fetus, and 3D volumetric images of cases with abnormal or indeterminate RNT were obtained.

RESULTS

Satisfactory images were obtained from all cases. Seven cases (1.4‰) of abnormal RNT were diagnosed as OC in the first trimester, which were confirmed at a 16 weeks scan or at a postmortem examination. One case that was considered a normal RNT was diagnosed with OC at 22(+2) weeks and after term delivery. Six cases of indeterminate RNT were diagnosed as normal by 3D ultrasound. Identification of OC by visualization of the RNT in the first trimester had a sensitivity of 87.5% and a specificity of 99.9%.

CONCLUSION

The RNT is an important sonographic landmark that has a high sensitivity and specificity for the detection of OC in the first trimester. 3D ultrasound is an important tool that aids in confirming diagnosis of OC in the first and second trimesters.

Authors+Show Affiliations

Department of Fetal Medicine, First Affiliated Hospital of Jinan University, Guangzhou, PR China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25613219

Citation

Li, Wei-Jing, et al. "Clinical Significance of First-Trimester Screening of the Retronasal Triangle for Identification of Primary Cleft Palate." Fetal Diagnosis and Therapy, vol. 38, no. 2, 2015, pp. 135-41.
Li WJ, Wang XQ, Yan RL, et al. Clinical Significance of First-Trimester Screening of the Retronasal Triangle for Identification of Primary Cleft Palate. Fetal Diagn Ther. 2015;38(2):135-41.
Li, W. J., Wang, X. Q., Yan, R. L., & Xiang, J. W. (2015). Clinical Significance of First-Trimester Screening of the Retronasal Triangle for Identification of Primary Cleft Palate. Fetal Diagnosis and Therapy, 38(2), 135-41. https://doi.org/10.1159/000369797
Li WJ, et al. Clinical Significance of First-Trimester Screening of the Retronasal Triangle for Identification of Primary Cleft Palate. Fetal Diagn Ther. 2015;38(2):135-41. PubMed PMID: 25613219.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical Significance of First-Trimester Screening of the Retronasal Triangle for Identification of Primary Cleft Palate. AU - Li,Wei-Jing, AU - Wang,Xue-Qin, AU - Yan,Rui-Ling, AU - Xiang,Jing-Wen, Y1 - 2015/01/22/ PY - 2014/04/29/received PY - 2014/10/31/accepted PY - 2015/1/24/entrez PY - 2015/1/24/pubmed PY - 2016/5/27/medline SP - 135 EP - 41 JF - Fetal diagnosis and therapy JO - Fetal Diagn Ther VL - 38 IS - 2 N2 - OBJECTIVE: To investigate the use of the retronasal triangle (RNT) for identification of orofacial cleft (OC) in the first trimester and the clinical application of three-dimensional (3D) ultrasound techniques for confirming the diagnosis of OC. METHODS: A total of 5,054 women with singleton pregnancies underwent first-trimester screening for Down syndrome at 11-13(+6) weeks. The RNT was scanned in each fetus, and 3D volumetric images of cases with abnormal or indeterminate RNT were obtained. RESULTS: Satisfactory images were obtained from all cases. Seven cases (1.4‰) of abnormal RNT were diagnosed as OC in the first trimester, which were confirmed at a 16 weeks scan or at a postmortem examination. One case that was considered a normal RNT was diagnosed with OC at 22(+2) weeks and after term delivery. Six cases of indeterminate RNT were diagnosed as normal by 3D ultrasound. Identification of OC by visualization of the RNT in the first trimester had a sensitivity of 87.5% and a specificity of 99.9%. CONCLUSION: The RNT is an important sonographic landmark that has a high sensitivity and specificity for the detection of OC in the first trimester. 3D ultrasound is an important tool that aids in confirming diagnosis of OC in the first and second trimesters. SN - 1421-9964 UR - https://www.unboundmedicine.com/medline/citation/25613219/Clinical_Significance_of_First_Trimester_Screening_of_the_Retronasal_Triangle_for_Identification_of_Primary_Cleft_Palate_ L2 - https://www.karger.com?DOI=10.1159/000369797 DB - PRIME DP - Unbound Medicine ER -