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Mycoplasma pneumonia increases the risk of acute coronary syndrome: a nationwide population-based cohort study.
QJM. 2015 Sep; 108(9):697-703.QJM

Abstract

BACKGROUND

Studies investigating the epidemiological relationship between Mycoplasma pneumonia (MP) and the subsequent development of acute coronary syndrome (ACS) are scant. We conducted a nationwide longitudinal cohort study in Taiwan to explore whether MP patients are at an increased risk of developing ACS.

METHODS

This study investigated the incidence and risk factors for ACS in 12 152 newly diagnosed MP patients from the Taiwan National Health Insurance Research Database between 2004 and 2011. The control group consisted of 48 600 individuals without MP. The follow-up period ran from the time of initial MP diagnosis to the date of an ACS event, censoring, or 31 December 2011. We analyzed the risk of ACS by using Cox proportional hazard regression models, including variables for sex, age and comorbidities.

RESULTS

The incidence of ACS was higher in MP patients than in comparison cohort (3.08 vs. 2.42 per 1000 person-years). The hazard ratio of developing ACS increased 37% in MP patients compared with that in the comparison cohort after adjustment for covariates. The effect of MP on subsequent ACS development appeared to 12 months after infection.

CONCLUSION

This nationwide study determined that compared with the general population, MP patients exhibited a 37% increase in the risk of subsequently developing ACS. Clinicians should be aware of this risk in MP patients and provide appropriate cardiovascular management in addition to MP treatment.

Authors+Show Affiliations

From the Department of Internal Medicine, Taichung Hospital, Ministry of Health and Welfare, Department of Health Services Administration, China Medical University, Department of Healthcare Administration, Central Taiwan University of Science and Technology.Department of Respiratory and Critical Care, China Medical University Hospital, Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University.Management Office for Health Data, China Medical University Hospital, College of Medicine, China Medical University and.Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan d10040@mail.cmuh.org.tw.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25614614

Citation

Chung, W-S, et al. "Mycoplasma Pneumonia Increases the Risk of Acute Coronary Syndrome: a Nationwide Population-based Cohort Study." QJM : Monthly Journal of the Association of Physicians, vol. 108, no. 9, 2015, pp. 697-703.
Chung WS, Hsu WH, Lin CL, et al. Mycoplasma pneumonia increases the risk of acute coronary syndrome: a nationwide population-based cohort study. QJM. 2015;108(9):697-703.
Chung, W. S., Hsu, W. H., Lin, C. L., & Kao, C. H. (2015). Mycoplasma pneumonia increases the risk of acute coronary syndrome: a nationwide population-based cohort study. QJM : Monthly Journal of the Association of Physicians, 108(9), 697-703. https://doi.org/10.1093/qjmed/hcv015
Chung WS, et al. Mycoplasma Pneumonia Increases the Risk of Acute Coronary Syndrome: a Nationwide Population-based Cohort Study. QJM. 2015;108(9):697-703. PubMed PMID: 25614614.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mycoplasma pneumonia increases the risk of acute coronary syndrome: a nationwide population-based cohort study. AU - Chung,W-S, AU - Hsu,W-H, AU - Lin,C-L, AU - Kao,C-H, Y1 - 2015/01/21/ PY - 2014/11/18/received PY - 2015/1/24/entrez PY - 2015/1/24/pubmed PY - 2016/6/2/medline SP - 697 EP - 703 JF - QJM : monthly journal of the Association of Physicians JO - QJM VL - 108 IS - 9 N2 - BACKGROUND: Studies investigating the epidemiological relationship between Mycoplasma pneumonia (MP) and the subsequent development of acute coronary syndrome (ACS) are scant. We conducted a nationwide longitudinal cohort study in Taiwan to explore whether MP patients are at an increased risk of developing ACS. METHODS: This study investigated the incidence and risk factors for ACS in 12 152 newly diagnosed MP patients from the Taiwan National Health Insurance Research Database between 2004 and 2011. The control group consisted of 48 600 individuals without MP. The follow-up period ran from the time of initial MP diagnosis to the date of an ACS event, censoring, or 31 December 2011. We analyzed the risk of ACS by using Cox proportional hazard regression models, including variables for sex, age and comorbidities. RESULTS: The incidence of ACS was higher in MP patients than in comparison cohort (3.08 vs. 2.42 per 1000 person-years). The hazard ratio of developing ACS increased 37% in MP patients compared with that in the comparison cohort after adjustment for covariates. The effect of MP on subsequent ACS development appeared to 12 months after infection. CONCLUSION: This nationwide study determined that compared with the general population, MP patients exhibited a 37% increase in the risk of subsequently developing ACS. Clinicians should be aware of this risk in MP patients and provide appropriate cardiovascular management in addition to MP treatment. SN - 1460-2393 UR - https://www.unboundmedicine.com/medline/citation/25614614/Mycoplasma_pneumonia_increases_the_risk_of_acute_coronary_syndrome:_a_nationwide_population_based_cohort_study_ DB - PRIME DP - Unbound Medicine ER -