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Proteolytic catabolite inactivation in Saccharomyces cerevisiae.
Revis Biol Celular. 1989; 21:305-19.RB

Abstract

Fermentable sugars, when added to cells of Saccharomyces cerevisiae growing on a non-fermentable carbon source, cause repression of the synthesis of certain enzymes ("catabolite repression") and in addition inactivation of a smaller group of enzymes ("catabolite inactivation"). Enzymes for which "catabolite inactivation" has been observed are listed herein. In five cases, it has been shown that the mechanism of catabolite inactivation is proteolytic in nature. Our present knowledge on the conditions and the mechanisms of initiation of inactivation and the biological significance of the proteolytic inactivation is summarized for these five enzymes: cytoplasmic malate dehydrogenase, aminopeptidase I, fructose-1,6-bisphosphatase (FBPase), phosphoenolpyruvate carboxykinase and isocitrate lyase. With the exception of aminopeptidase I, these enzymes are key enzymes of gluconeogenesis in S. cerevisiae. It is obvious that gluconeogenesis is no longer necessary, if a fermentable carbon source is available.

Authors+Show Affiliations

Holzer H
Biochemisches Institut, Universität Freiburg, West Germany.

MeSH

AminopeptidasesCyclic AMPCytoplasmFructose-BisphosphataseFungal ProteinsGluconeogenesisGlucoseIsocitrate LyaseMalate DehydrogenasePhosphoenolpyruvate Carboxykinase (GTP)Saccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSubcellular Fractions

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

2561496

Citation

Holzer, H. "Proteolytic Catabolite Inactivation in Saccharomyces Cerevisiae." Revisiones Sobre Biologia Celular : RBC, vol. 21, 1989, pp. 305-19.
Holzer H. Proteolytic catabolite inactivation in Saccharomyces cerevisiae. Revis Biol Celular. 1989;21:305-19.
Holzer, H. (1989). Proteolytic catabolite inactivation in Saccharomyces cerevisiae. Revisiones Sobre Biologia Celular : RBC, 21, 305-19.
Holzer H. Proteolytic Catabolite Inactivation in Saccharomyces Cerevisiae. Revis Biol Celular. 1989;21:305-19. PubMed PMID: 2561496.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Proteolytic catabolite inactivation in Saccharomyces cerevisiae. A1 - Holzer,H, PY - 1989/1/1/pubmed PY - 1989/1/1/medline PY - 1989/1/1/entrez SP - 305 EP - 19 JF - Revisiones sobre biologia celular : RBC JO - Revis Biol Celular VL - 21 N2 - Fermentable sugars, when added to cells of Saccharomyces cerevisiae growing on a non-fermentable carbon source, cause repression of the synthesis of certain enzymes ("catabolite repression") and in addition inactivation of a smaller group of enzymes ("catabolite inactivation"). Enzymes for which "catabolite inactivation" has been observed are listed herein. In five cases, it has been shown that the mechanism of catabolite inactivation is proteolytic in nature. Our present knowledge on the conditions and the mechanisms of initiation of inactivation and the biological significance of the proteolytic inactivation is summarized for these five enzymes: cytoplasmic malate dehydrogenase, aminopeptidase I, fructose-1,6-bisphosphatase (FBPase), phosphoenolpyruvate carboxykinase and isocitrate lyase. With the exception of aminopeptidase I, these enzymes are key enzymes of gluconeogenesis in S. cerevisiae. It is obvious that gluconeogenesis is no longer necessary, if a fermentable carbon source is available. SN - 0213-7119 UR - https://www.unboundmedicine.com/medline/citation/2561496/Proteolytic_catabolite_inactivation_in_Saccharomyces_cerevisiae_ DB - PRIME DP - Unbound Medicine ER -