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Armochaeglobines A and B, two new indole-based alkaloids from the arthropod-derived fungus Chaetomium globosum.
Org Lett. 2015 Feb 06; 17(3):644-7.OL

Abstract

Armochaeglobines A (1) and B (2), two indole-based cytochalasan alkaloids with new carbon skeletons, were obtained from the fungus Chaetomium globosum TW1-1, which was first isolated from the arthropod Armadillidium vulgare. Their structures were elucidated by extensive spectroscopic analyses, ECD calculation, and single-crystal X-ray diffraction analysis. Interestingly, compound 1 featured a unique tetracyclic 5/6/7/5 fused ring system and 2 possessed a rare 12-membered carbon scaffold.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Chen C
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, China.
Zhu H
No affiliation info available
Li XN
No affiliation info available
Yang J
No affiliation info available
Wang J
No affiliation info available
Li G
No affiliation info available
Li Y
No affiliation info available
Tong Q
No affiliation info available
Yao G
No affiliation info available
Luo Z
No affiliation info available
Xue Y
No affiliation info available
Zhang Y
No affiliation info available

MeSH

AnimalsAntineoplastic AgentsArthropodsChaetomiumCrystallography, X-RayCytochalasinsDrug Screening Assays, AntitumorIndole AlkaloidsMolecular ConformationMolecular StructureX-Ray Diffraction

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25615686

Citation

Chen, Chunmei, et al. "Armochaeglobines a and B, Two New Indole-based Alkaloids From the Arthropod-derived Fungus Chaetomium Globosum." Organic Letters, vol. 17, no. 3, 2015, pp. 644-7.
Chen C, Zhu H, Li XN, et al. Armochaeglobines A and B, two new indole-based alkaloids from the arthropod-derived fungus Chaetomium globosum. Org Lett. 2015;17(3):644-7.
Chen, C., Zhu, H., Li, X. N., Yang, J., Wang, J., Li, G., Li, Y., Tong, Q., Yao, G., Luo, Z., Xue, Y., & Zhang, Y. (2015). Armochaeglobines A and B, two new indole-based alkaloids from the arthropod-derived fungus Chaetomium globosum. Organic Letters, 17(3), 644-7. https://doi.org/10.1021/ol503666b
Chen C, et al. Armochaeglobines a and B, Two New Indole-based Alkaloids From the Arthropod-derived Fungus Chaetomium Globosum. Org Lett. 2015 Feb 6;17(3):644-7. PubMed PMID: 25615686.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Armochaeglobines A and B, two new indole-based alkaloids from the arthropod-derived fungus Chaetomium globosum. AU - Chen,Chunmei, AU - Zhu,Hucheng, AU - Li,Xiao-Nian, AU - Yang,Jing, AU - Wang,Jianping, AU - Li,Gentao, AU - Li,Yan, AU - Tong,Qingyi, AU - Yao,Guangmin, AU - Luo,Zengwei, AU - Xue,Yongbo, AU - Zhang,Yonghui, Y1 - 2015/01/23/ PY - 2015/1/24/entrez PY - 2015/1/24/pubmed PY - 2015/4/9/medline SP - 644 EP - 7 JF - Organic letters JO - Org Lett VL - 17 IS - 3 N2 - Armochaeglobines A (1) and B (2), two indole-based cytochalasan alkaloids with new carbon skeletons, were obtained from the fungus Chaetomium globosum TW1-1, which was first isolated from the arthropod Armadillidium vulgare. Their structures were elucidated by extensive spectroscopic analyses, ECD calculation, and single-crystal X-ray diffraction analysis. Interestingly, compound 1 featured a unique tetracyclic 5/6/7/5 fused ring system and 2 possessed a rare 12-membered carbon scaffold. SN - 1523-7052 UR - https://www.unboundmedicine.com/medline/citation/25615686/Armochaeglobines_A_and_B_two_new_indole_based_alkaloids_from_the_arthropod_derived_fungus_Chaetomium_globosum_ DB - PRIME DP - Unbound Medicine ER -