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Ebselen Attenuates Lung Injury in Experimental Model of Carrageenan-Induced Pleurisy in Rats.
Inflammation. 2015 Aug; 38(4):1394-400.I

Abstract

The study evaluates the role of Ebselen (Eb), an organoselenium compound in animal model of acute lung injury induced by carrageenan (CG). Wistar rats received saline or 2 % λ-carrageenan in the pleural cavity, and treatment with Eb (50 mg/kg intragastrically) or dexamethasone (Dx) (0.5 mg/kg intraperitoneal) after CG administration. After 4 h, rats were euthanized and the pleural exudate removed for analysis of the total cell count, total protein, lactate dehydrogenase, and nitrite/nitrate. Moreover, lung tissue were removed to verify the myeloperoxidase activity and oxidative damage. Eb showed anti-inflammatory activity by inhibiting leukocyte influx, myeloperoxidase activity, and nitrite/nitrate concentration. Eb presented with an anti-inflammatory activity similar to Dx and an antioxidant activity better than Dx. This study suggests that Eb plays an important role against the oxidative damage associated with anti-inflammatory activity in animal model of acute lung injury, proving to be similar or potentially more effective than Dx.

Authors+Show Affiliations

Laboratory of Clinical and Experimental Pathophysiology, Postgraduate Program in Health Sciences, University of South Santa Catarina, Tubarao, SC, Brazil, fabriciapetronilho@yahoo.com.br.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25616904

Citation

Petronilho, Fabricia, et al. "Ebselen Attenuates Lung Injury in Experimental Model of Carrageenan-Induced Pleurisy in Rats." Inflammation, vol. 38, no. 4, 2015, pp. 1394-400.
Petronilho F, Florentino D, Silvestre F, et al. Ebselen Attenuates Lung Injury in Experimental Model of Carrageenan-Induced Pleurisy in Rats. Inflammation. 2015;38(4):1394-400.
Petronilho, F., Florentino, D., Silvestre, F., Danielski, L. G., Nascimento, D. Z., Vieira, A., Kanis, L. A., Fortunato, J. J., Badawy, M., Barichello, T., & Quevedo, J. (2015). Ebselen Attenuates Lung Injury in Experimental Model of Carrageenan-Induced Pleurisy in Rats. Inflammation, 38(4), 1394-400. https://doi.org/10.1007/s10753-015-0113-5
Petronilho F, et al. Ebselen Attenuates Lung Injury in Experimental Model of Carrageenan-Induced Pleurisy in Rats. Inflammation. 2015;38(4):1394-400. PubMed PMID: 25616904.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ebselen Attenuates Lung Injury in Experimental Model of Carrageenan-Induced Pleurisy in Rats. AU - Petronilho,Fabricia, AU - Florentino,Drielly, AU - Silvestre,Fernanda, AU - Danielski,Lucineia Gainski, AU - Nascimento,Diego Zapelini, AU - Vieira,Andriele, AU - Kanis,Luiz Alberto, AU - Fortunato,Jucelia Jeremias, AU - Badawy,Marwa, AU - Barichello,Tatiana, AU - Quevedo,Joao, PY - 2015/1/25/entrez PY - 2015/1/27/pubmed PY - 2016/4/19/medline SP - 1394 EP - 400 JF - Inflammation JO - Inflammation VL - 38 IS - 4 N2 - The study evaluates the role of Ebselen (Eb), an organoselenium compound in animal model of acute lung injury induced by carrageenan (CG). Wistar rats received saline or 2 % λ-carrageenan in the pleural cavity, and treatment with Eb (50 mg/kg intragastrically) or dexamethasone (Dx) (0.5 mg/kg intraperitoneal) after CG administration. After 4 h, rats were euthanized and the pleural exudate removed for analysis of the total cell count, total protein, lactate dehydrogenase, and nitrite/nitrate. Moreover, lung tissue were removed to verify the myeloperoxidase activity and oxidative damage. Eb showed anti-inflammatory activity by inhibiting leukocyte influx, myeloperoxidase activity, and nitrite/nitrate concentration. Eb presented with an anti-inflammatory activity similar to Dx and an antioxidant activity better than Dx. This study suggests that Eb plays an important role against the oxidative damage associated with anti-inflammatory activity in animal model of acute lung injury, proving to be similar or potentially more effective than Dx. SN - 1573-2576 UR - https://www.unboundmedicine.com/medline/citation/25616904/Ebselen_Attenuates_Lung_Injury_in_Experimental_Model_of_Carrageenan_Induced_Pleurisy_in_Rats_ L2 - https://doi.org/10.1007/s10753-015-0113-5 DB - PRIME DP - Unbound Medicine ER -