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Safety in the hypertriglyceridemia treatment with N-3 polyunsaturated fatty acids on glucose metabolism in subjects with type 2 diabetes mellitus.
Nutr Hosp 2014; 31(2):570-6NH

Abstract

INTRODUCTION

Type 2 diabetes mellitus increases the risk of hypertriglyceridemia and is an independent risk factor for cardiovascular diseases. Current literature reveals the beneficial effects of n-3 polyunsaturated fatty acids (n-3 PUFA) in hypertriglyceridemia treatment, however the safety for type 2 diabetic subjects are still debatable. This literature review discusses the safety on glucose metabolism of n-3 PUFA supplementation in the treatment of hypertriglyceridemia in subjects with type 2 diabetes mellitus.

METHODS

A literature review was conducted on EMBASE and MEDLINE database to investigate clinical trials published since 1990 until June 2014 that investigated the effects of dietary/supplementation n-3 PUFA intake in hypertriglyceridemia treatment in subjects with type 2 diabetes mellitus.

RESULTS AND DISCUSSION

Fourteen clinical trials (n = 2,105) were included in this review. All trials reported a reduction in triglycerides levels between 12 - 34% in intra- group and 15 - 36% in between-groups analysis. Four trials showed a significant increase in LDL-c (6 - 18%) and another four in HDL-c levels (4 - 15%). No significant changes were found to total cholesterol, VLDL-c, fasting glucose, HbA1C, and insulin sensitivity index.

CONCLUSIONS

The n-3 PUFA supplementation leads an improvement on TG levels and did not result in any impairment on glucose metabolism in hypertriglyceridemic patients with type 2 diabetes mellitus being a safe option to treat the diabetic population.

Authors+Show Affiliations

School of Health Sciences, University of Brasilia, Brazil.. caioedureis@gmail.com.Doce Desafio Program, University of Brasilia, Brazil.. caioedureis@gmail.com.Department of Pharmacy, University of Brasilia, Brazil.. caioedureis@gmail.com.School of Physical Education, University of Brasilia, Brazil.. caioedureis@gmail.com.

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

25617537

Citation

Reis, Caio Eduardo Gonçalves, et al. "Safety in the Hypertriglyceridemia Treatment With N-3 Polyunsaturated Fatty Acids On Glucose Metabolism in Subjects With Type 2 Diabetes Mellitus." Nutricion Hospitalaria, vol. 31, no. 2, 2014, pp. 570-6.
Reis CE, Landim KC, Nunes AC, et al. Safety in the hypertriglyceridemia treatment with N-3 polyunsaturated fatty acids on glucose metabolism in subjects with type 2 diabetes mellitus. Nutr Hosp. 2014;31(2):570-6.
Reis, C. E., Landim, K. C., Nunes, A. C., & Dullius, J. (2014). Safety in the hypertriglyceridemia treatment with N-3 polyunsaturated fatty acids on glucose metabolism in subjects with type 2 diabetes mellitus. Nutricion Hospitalaria, 31(2), pp. 570-6. doi:10.3305/nh.2015.31.2.7845.
Reis CE, et al. Safety in the Hypertriglyceridemia Treatment With N-3 Polyunsaturated Fatty Acids On Glucose Metabolism in Subjects With Type 2 Diabetes Mellitus. Nutr Hosp. 2014 Oct 6;31(2):570-6. PubMed PMID: 25617537.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Safety in the hypertriglyceridemia treatment with N-3 polyunsaturated fatty acids on glucose metabolism in subjects with type 2 diabetes mellitus. AU - Reis,Caio Eduardo Gonçalves, AU - Landim,Karla Câmara, AU - Nunes,Aline Costa Santos, AU - Dullius,Jane, Y1 - 2014/10/06/ PY - 2015/1/25/entrez PY - 2015/1/27/pubmed PY - 2016/11/8/medline SP - 570 EP - 6 JF - Nutricion hospitalaria JO - Nutr Hosp VL - 31 IS - 2 N2 - INTRODUCTION: Type 2 diabetes mellitus increases the risk of hypertriglyceridemia and is an independent risk factor for cardiovascular diseases. Current literature reveals the beneficial effects of n-3 polyunsaturated fatty acids (n-3 PUFA) in hypertriglyceridemia treatment, however the safety for type 2 diabetic subjects are still debatable. This literature review discusses the safety on glucose metabolism of n-3 PUFA supplementation in the treatment of hypertriglyceridemia in subjects with type 2 diabetes mellitus. METHODS: A literature review was conducted on EMBASE and MEDLINE database to investigate clinical trials published since 1990 until June 2014 that investigated the effects of dietary/supplementation n-3 PUFA intake in hypertriglyceridemia treatment in subjects with type 2 diabetes mellitus. RESULTS AND DISCUSSION: Fourteen clinical trials (n = 2,105) were included in this review. All trials reported a reduction in triglycerides levels between 12 - 34% in intra- group and 15 - 36% in between-groups analysis. Four trials showed a significant increase in LDL-c (6 - 18%) and another four in HDL-c levels (4 - 15%). No significant changes were found to total cholesterol, VLDL-c, fasting glucose, HbA1C, and insulin sensitivity index. CONCLUSIONS: The n-3 PUFA supplementation leads an improvement on TG levels and did not result in any impairment on glucose metabolism in hypertriglyceridemic patients with type 2 diabetes mellitus being a safe option to treat the diabetic population. SN - 1699-5198 UR - https://www.unboundmedicine.com/medline/citation/25617537/Safety_in_the_hypertriglyceridemia_treatment_with_N_3_polyunsaturated_fatty_acids_on_glucose_metabolism_in_subjects_with_type_2_diabetes_mellitus_ L2 - http://www.aulamedica.es/nh/pdf/7845.pdf DB - PRIME DP - Unbound Medicine ER -