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Protective effect of olive oil and colocynth oil against cadmium-induced oxidative stress in the liver of Wistar rats.
Food Chem Toxicol. 2015 Apr; 78:177-84.FC

Abstract

Cadmium (Cd) is one of the most common heavy metal pollutants. It is accumulated particularly in liver and kidney. The present study examined the possible protective effect of olive oil and colocynth oil consumption against Cd-induced damage on plasma lipids and stress biochemical parameters of rats. Male albino Wistar rats were randomly divided into 6 groups of 5 animals each and treated orally with Cd (50 mg/l), olive oil and colocynth oil (4%) alone or in combination with cadmium for 8 weeks. It was shown that Cd exposure induced significant increases in the activities of serum alanine aminotransferase, aspartate aminotransferase, lipid peroxidation levels (MDA) and protein carbonyl contents in exposed groups of rats compared to control group while the antioxidant enzymes, reduced glutathione and vitamins (C, A and E) were significantly decreased. Co-treatment with olive oil or colocynth oil significantly improved the oxidative damage induced by Cd. The antioxidant potential in plasma and liver were markedly restored with a significant decline in MDA levels and activity of transaminases. In conclusion, these results suggest that olive oil or colocynth oil consumption could protect the rat liver against Cd-induced injury by increasing the activities of antioxidant enzymes and reducing oxidative stress.

Authors+Show Affiliations

Laboratory of natural products, LAPRONA, Faculty of SNV-STU, University of Tlemcen, BP 119 Imama, Tlemcen 13000, Algeria.Laboratory of natural products, LAPRONA, Faculty of SNV-STU, University of Tlemcen, BP 119 Imama, Tlemcen 13000, Algeria; Department of biology, Faculty of SNV, University of Mostaganem, Mostaganem 27000, Algeria. Electronic address: snemiche@hotmail.com.Laboratory of natural products, LAPRONA, Faculty of SNV-STU, University of Tlemcen, BP 119 Imama, Tlemcen 13000, Algeria.Laboratory of natural products, LAPRONA, Faculty of SNV-STU, University of Tlemcen, BP 119 Imama, Tlemcen 13000, Algeria.Laboratory of natural products, LAPRONA, Faculty of SNV-STU, University of Tlemcen, BP 119 Imama, Tlemcen 13000, Algeria.Laboratory of natural products, LAPRONA, Faculty of SNV-STU, University of Tlemcen, BP 119 Imama, Tlemcen 13000, Algeria.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25617810

Citation

Amamou, Fouzia, et al. "Protective Effect of Olive Oil and Colocynth Oil Against Cadmium-induced Oxidative Stress in the Liver of Wistar Rats." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 78, 2015, pp. 177-84.
Amamou F, Nemmiche S, Meziane RK, et al. Protective effect of olive oil and colocynth oil against cadmium-induced oxidative stress in the liver of Wistar rats. Food Chem Toxicol. 2015;78:177-84.
Amamou, F., Nemmiche, S., Meziane, R. K., Didi, A., Yazit, S. M., & Chabane-Sari, D. (2015). Protective effect of olive oil and colocynth oil against cadmium-induced oxidative stress in the liver of Wistar rats. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 78, 177-84. https://doi.org/10.1016/j.fct.2015.01.001
Amamou F, et al. Protective Effect of Olive Oil and Colocynth Oil Against Cadmium-induced Oxidative Stress in the Liver of Wistar Rats. Food Chem Toxicol. 2015;78:177-84. PubMed PMID: 25617810.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of olive oil and colocynth oil against cadmium-induced oxidative stress in the liver of Wistar rats. AU - Amamou,Fouzia, AU - Nemmiche,Saïd, AU - Meziane,Radjaa Kaouthar, AU - Didi,Amal, AU - Yazit,Sidi Mohamed, AU - Chabane-Sari,Daoudi, Y1 - 2015/01/21/ PY - 2014/05/23/received PY - 2014/12/30/revised PY - 2015/01/05/accepted PY - 2015/1/25/entrez PY - 2015/1/27/pubmed PY - 2015/12/19/medline KW - Cadmium KW - Colocynth oil KW - Liver KW - Olive oil KW - Oxidative stress KW - Rats SP - 177 EP - 84 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 78 N2 - Cadmium (Cd) is one of the most common heavy metal pollutants. It is accumulated particularly in liver and kidney. The present study examined the possible protective effect of olive oil and colocynth oil consumption against Cd-induced damage on plasma lipids and stress biochemical parameters of rats. Male albino Wistar rats were randomly divided into 6 groups of 5 animals each and treated orally with Cd (50 mg/l), olive oil and colocynth oil (4%) alone or in combination with cadmium for 8 weeks. It was shown that Cd exposure induced significant increases in the activities of serum alanine aminotransferase, aspartate aminotransferase, lipid peroxidation levels (MDA) and protein carbonyl contents in exposed groups of rats compared to control group while the antioxidant enzymes, reduced glutathione and vitamins (C, A and E) were significantly decreased. Co-treatment with olive oil or colocynth oil significantly improved the oxidative damage induced by Cd. The antioxidant potential in plasma and liver were markedly restored with a significant decline in MDA levels and activity of transaminases. In conclusion, these results suggest that olive oil or colocynth oil consumption could protect the rat liver against Cd-induced injury by increasing the activities of antioxidant enzymes and reducing oxidative stress. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/25617810/Protective_effect_of_olive_oil_and_colocynth_oil_against_cadmium_induced_oxidative_stress_in_the_liver_of_Wistar_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(15)00005-8 DB - PRIME DP - Unbound Medicine ER -