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Mechanisms of eccrine anidrosis. I. High level blockade.
J Invest Dermatol 1966; 47(1):1-9JI

Abstract

The cause of anidrosis of the chronic dermatoses, hydration, and that produced experimentally by protein precipitants is superficial obstruction of the eccrine duct. In each instance, return of sweating in the anidrotic area is effected simply by removal of the stratum corneum with Scotch Tape stripping. The histologic picture common to this type of anidrosis is ductal dilatation following an adequate sweat stress. The presence of an obstruction, whether functional or anatomic, is confirmed by the inability to achieve a methylene blue pore pattern. Parakeratotic plugging of the eccrine ostia is primarily responsible for the obstruction in the spontaneous dermatoses, while actual intraluminal casts are produced chemically by the protein denaturants, high within the stratum corneum portion of the eccrine duct. The PAS positive, diastase resistant casts regularly found in blocked ducts are secondary to the obstruction and are not a primary cause. No adequate explanation has been found for the persistent anidrosis after occlusion of the skin with impermeable plastic dressings.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

25622342

Citation

Papa, C M., and A M. Kligman. "Mechanisms of Eccrine Anidrosis. I. High Level Blockade." The Journal of Investigative Dermatology, vol. 47, no. 1, 1966, pp. 1-9.
Papa CM, Kligman AM. Mechanisms of eccrine anidrosis. I. High level blockade. J Invest Dermatol. 1966;47(1):1-9.
Papa, C. M., & Kligman, A. M. (1966). Mechanisms of eccrine anidrosis. I. High level blockade. The Journal of Investigative Dermatology, 47(1), pp. 1-9.
Papa CM, Kligman AM. Mechanisms of Eccrine Anidrosis. I. High Level Blockade. J Invest Dermatol. 1966;47(1):1-9. PubMed PMID: 25622342.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mechanisms of eccrine anidrosis. I. High level blockade. AU - Papa,C M, AU - Kligman,A M, PY - 2015/1/28/entrez PY - 1966/8/1/pubmed PY - 2015/3/21/medline SP - 1 EP - 9 JF - The Journal of investigative dermatology JO - J. Invest. Dermatol. VL - 47 IS - 1 N2 - The cause of anidrosis of the chronic dermatoses, hydration, and that produced experimentally by protein precipitants is superficial obstruction of the eccrine duct. In each instance, return of sweating in the anidrotic area is effected simply by removal of the stratum corneum with Scotch Tape stripping. The histologic picture common to this type of anidrosis is ductal dilatation following an adequate sweat stress. The presence of an obstruction, whether functional or anatomic, is confirmed by the inability to achieve a methylene blue pore pattern. Parakeratotic plugging of the eccrine ostia is primarily responsible for the obstruction in the spontaneous dermatoses, while actual intraluminal casts are produced chemically by the protein denaturants, high within the stratum corneum portion of the eccrine duct. The PAS positive, diastase resistant casts regularly found in blocked ducts are secondary to the obstruction and are not a primary cause. No adequate explanation has been found for the persistent anidrosis after occlusion of the skin with impermeable plastic dressings. SN - 0022-202X UR - https://www.unboundmedicine.com/medline/citation/25622342/Mechanisms_of_eccrine_anidrosis._I._High_level_blockade L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-202X(15)47143-X DB - PRIME DP - Unbound Medicine ER -