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Nutrition and psoriasis: is there any association between the severity of the disease and adherence to the Mediterranean diet?

Abstract

BACKGROUND

Many studies have evaluated the role of individual nutrients on the development of psoriasis. However, only few studies have investigated the effect of a healthy eating pattern, such as the Mediterranean diet. In this study, we aimed to investigate the relationship between adherence to the Mediterranean diet, the body composition and the severity of psoriasis in a group of naïve-treatment patients with psoriasis.

METHODS

This is a cross-sectional case-control observational study. Sixty-two patients (49 males and 13 females, mean age: 50.2±10.5yrs) affected with mild-to-severe psoriasis were consecutively enrolled. Sixty-two age-, sex- and body mass index (BMI)-matched healthy subjects served as control group. A validated 14-item questionnaire (PREDIMED: PREvención con DIeta MEDiterránea) was used for the assessment of adherence to the Mediterranean diet. The severity of psoriasis was by assessed by standardized Psoriasis Area and Severity Index (PASI) score and C-reactive protein (CRP) levels. Body composition was analyzed with bioelectrical impedance analysis.

RESULTS

A higher percentage of psoriatic patients had a lower PREDIMED score compared to the control group (30.6% vs 4.8%). PASI score was significantly associated with the percentage of fat mass (FM%) and CRP levels. PASI score and CRP levels were significantly associated with the dietary components included in the PREDIMED questionnaire or with the PREDIMED score. At multiple regression analysis, the major predictor of PASI score were FM among BIA parameters, (r(2)=0.537, β=0.740, p<0.001), and FM (r(2)=0.537, β=0.603, p<0.001) and PREDIMED score (r(2)=0.599, β=-0.296, p=0.007) among anthropometric measures, FM and PREDIMED score. Finally, among all items of the PREDIMED questionnaire, EVOO (r(2)=0.548, β=-0.741, p<0.001), and fish consumption (r(2)=0.139, β=-0.372, p=0.005) have an independent predictive value for PASI score and CRP levels.

CONCLUSIONS

This is the first study to evaluate the association between adherence to the Mediterranean diet and the severity of psoriasis. Moreover, our study highlights the usefulness of the assessment of body composition by bioelectrical impedance analysis in the evaluation of the psoriatic patients.

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  • Authors+Show Affiliations

    ,

    I.O.S. & COLEMAN Srl, Naples, Italy. luigi.barrea@unina.it.

    ,

    Dipartimento di Medicina Clinica e Chirurgia, Unit of Dermatology, Federico II University Medical School of Naples, Via Sergio Pansini 5, Naples, 80131, Italy. nicola.balato@unina.it.

    ,

    IRCCS SDN, Napoli Via Gianturco 113, Naples, 80143, Italy. cdisomma@unina.it.

    ,

    Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini 5, Naples, 80131, Italy. pmacchia@unina.it.

    ,

    Dipartimento di Medicina Clinica e Chirurgia, Unit of Dermatology, Federico II University Medical School of Naples, Via Sergio Pansini 5, Naples, 80131, Italy. maddy.napolitano@gmail.com.

    ,

    I.O.S. & COLEMAN Srl, Naples, Italy. cristysav@hotmail.com.

    ,

    Department of Clinical and Experimental Medicine, Second University of Naples, Via Costantinopoli, Naples, 84-80138, Italy. katherine.esposito@unina2.it.

    ,

    Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini 5, Naples, 80131, Italy. colao@unina.it.

    Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini 5, Naples, 80131, Italy. sisavast@unina.it.

    Source

    Journal of translational medicine 13: 2015 Jan 27 pg 18

    MeSH

    Adult
    Anthropometry
    Body Composition
    Body Mass Index
    C-Reactive Protein
    Case-Control Studies
    Cross-Sectional Studies
    Diet, Mediterranean
    Female
    Humans
    Male
    Middle Aged
    Nutritional Status
    Psoriasis
    Regression Analysis
    Risk Factors
    Severity of Illness Index
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Observational Study

    Language

    eng

    PubMed ID

    25622660

    Citation

    Barrea, Luigi, et al. "Nutrition and Psoriasis: Is There Any Association Between the Severity of the Disease and Adherence to the Mediterranean Diet?" Journal of Translational Medicine, vol. 13, 2015, p. 18.
    Barrea L, Balato N, Di Somma C, et al. Nutrition and psoriasis: is there any association between the severity of the disease and adherence to the Mediterranean diet? J Transl Med. 2015;13:18.
    Barrea, L., Balato, N., Di Somma, C., Macchia, P. E., Napolitano, M., Savanelli, M. C., ... Savastano, S. (2015). Nutrition and psoriasis: is there any association between the severity of the disease and adherence to the Mediterranean diet? Journal of Translational Medicine, 13, p. 18. doi:10.1186/s12967-014-0372-1.
    Barrea L, et al. Nutrition and Psoriasis: Is There Any Association Between the Severity of the Disease and Adherence to the Mediterranean Diet. J Transl Med. 2015 Jan 27;13:18. PubMed PMID: 25622660.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Nutrition and psoriasis: is there any association between the severity of the disease and adherence to the Mediterranean diet? AU - Barrea,Luigi, AU - Balato,Nicola, AU - Di Somma,Carolina, AU - Macchia,Paolo Emidio, AU - Napolitano,Maddalena, AU - Savanelli,Maria Cristina, AU - Esposito,Katherine, AU - Colao,Annamaria, AU - Savastano,Silvia, Y1 - 2015/01/27/ PY - 2014/11/17/received PY - 2014/12/23/accepted PY - 2015/1/28/entrez PY - 2015/1/28/pubmed PY - 2016/4/14/medline SP - 18 EP - 18 JF - Journal of translational medicine JO - J Transl Med VL - 13 N2 - BACKGROUND: Many studies have evaluated the role of individual nutrients on the development of psoriasis. However, only few studies have investigated the effect of a healthy eating pattern, such as the Mediterranean diet. In this study, we aimed to investigate the relationship between adherence to the Mediterranean diet, the body composition and the severity of psoriasis in a group of naïve-treatment patients with psoriasis. METHODS: This is a cross-sectional case-control observational study. Sixty-two patients (49 males and 13 females, mean age: 50.2±10.5yrs) affected with mild-to-severe psoriasis were consecutively enrolled. Sixty-two age-, sex- and body mass index (BMI)-matched healthy subjects served as control group. A validated 14-item questionnaire (PREDIMED: PREvención con DIeta MEDiterránea) was used for the assessment of adherence to the Mediterranean diet. The severity of psoriasis was by assessed by standardized Psoriasis Area and Severity Index (PASI) score and C-reactive protein (CRP) levels. Body composition was analyzed with bioelectrical impedance analysis. RESULTS: A higher percentage of psoriatic patients had a lower PREDIMED score compared to the control group (30.6% vs 4.8%). PASI score was significantly associated with the percentage of fat mass (FM%) and CRP levels. PASI score and CRP levels were significantly associated with the dietary components included in the PREDIMED questionnaire or with the PREDIMED score. At multiple regression analysis, the major predictor of PASI score were FM among BIA parameters, (r(2)=0.537, β=0.740, p<0.001), and FM (r(2)=0.537, β=0.603, p<0.001) and PREDIMED score (r(2)=0.599, β=-0.296, p=0.007) among anthropometric measures, FM and PREDIMED score. Finally, among all items of the PREDIMED questionnaire, EVOO (r(2)=0.548, β=-0.741, p<0.001), and fish consumption (r(2)=0.139, β=-0.372, p=0.005) have an independent predictive value for PASI score and CRP levels. CONCLUSIONS: This is the first study to evaluate the association between adherence to the Mediterranean diet and the severity of psoriasis. Moreover, our study highlights the usefulness of the assessment of body composition by bioelectrical impedance analysis in the evaluation of the psoriatic patients. SN - 1479-5876 UR - https://www.unboundmedicine.com/medline/citation/25622660/Nutrition_and_psoriasis:_is_there_any_association_between_the_severity_of_the_disease_and_adherence_to_the_Mediterranean_diet L2 - https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-014-0372-1 DB - PRIME DP - Unbound Medicine ER -