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What's new in atopic eczema? An analysis of systematic reviews published in 2012 and 2013. Part 2. Treatment and prevention.
Clin Exp Dermatol 2015; 40(4):349-54; quiz 354-5CE

Abstract

This review provides a summary of key findings from 22 systematic reviews on atopic eczema (AE) published over the 2-year period from January 2012 to 31 December 2013, focusing on prevention and treatment of AE. For an update of systematic reviews on the epidemiology, mechanisms of disease and methodological issues, see Part 1 of this update. Based on current systematic review evidence, the most promising intervention for the prevention of AE is the use of probiotics (and possibly prebiotics) during the late stages of pregnancy and early life. Exposure to household pets, especially dogs, may also be protective, but exclusive breastfeeding for up to 7 months does not confer benefit. The role of vitamin D in preventing AE is currently unclear. Very few of the systematic reviews provided additional evidence for the use of specific treatments for AE. Further research is required to establish the role of desensitization, Chinese herbal medicines, homeopathy and specialist clothing. Nevertheless, there is now clear evidence that evening primrose oil and borage oil are not effective for the treatment of AE. There have been no randomized controlled trials on the use of H1 anti-histamines as monotherapy for the treatment of AE.

Authors+Show Affiliations

Division of Population Health Sciences, University of Dundee, Dundee, UK.Division of Allergy, National Center for Child Health and Development, Tokyo, Japan.Centre of Evidence Based Dermatology, Division of Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham, Nottingham, UK.Centre of Evidence Based Dermatology, Division of Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham, Nottingham, UK. Dermatology Department, Nantes University Hospital, Nantes, France.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

25622761

Citation

Madhok, V, et al. "What's New in Atopic Eczema? an Analysis of Systematic Reviews Published in 2012 and 2013. Part 2. Treatment and Prevention." Clinical and Experimental Dermatology, vol. 40, no. 4, 2015, pp. 349-54; quiz 354-5.
Madhok V, Futamura M, Thomas KS, et al. What's new in atopic eczema? An analysis of systematic reviews published in 2012 and 2013. Part 2. Treatment and prevention. Clin Exp Dermatol. 2015;40(4):349-54; quiz 354-5.
Madhok, V., Futamura, M., Thomas, K. S., & Barbarot, S. (2015). What's new in atopic eczema? An analysis of systematic reviews published in 2012 and 2013. Part 2. Treatment and prevention. Clinical and Experimental Dermatology, 40(4), pp. 349-54; quiz 354-5. doi:10.1111/ced.12591.
Madhok V, et al. What's New in Atopic Eczema? an Analysis of Systematic Reviews Published in 2012 and 2013. Part 2. Treatment and Prevention. Clin Exp Dermatol. 2015;40(4):349-54; quiz 354-5. PubMed PMID: 25622761.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - What's new in atopic eczema? An analysis of systematic reviews published in 2012 and 2013. Part 2. Treatment and prevention. AU - Madhok,V, AU - Futamura,M, AU - Thomas,K S, AU - Barbarot,S, Y1 - 2015/01/27/ PY - 2014/10/07/accepted PY - 2015/1/28/entrez PY - 2015/1/28/pubmed PY - 2016/2/26/medline SP - 349-54; quiz 354-5 JF - Clinical and experimental dermatology JO - Clin. Exp. Dermatol. VL - 40 IS - 4 N2 - This review provides a summary of key findings from 22 systematic reviews on atopic eczema (AE) published over the 2-year period from January 2012 to 31 December 2013, focusing on prevention and treatment of AE. For an update of systematic reviews on the epidemiology, mechanisms of disease and methodological issues, see Part 1 of this update. Based on current systematic review evidence, the most promising intervention for the prevention of AE is the use of probiotics (and possibly prebiotics) during the late stages of pregnancy and early life. Exposure to household pets, especially dogs, may also be protective, but exclusive breastfeeding for up to 7 months does not confer benefit. The role of vitamin D in preventing AE is currently unclear. Very few of the systematic reviews provided additional evidence for the use of specific treatments for AE. Further research is required to establish the role of desensitization, Chinese herbal medicines, homeopathy and specialist clothing. Nevertheless, there is now clear evidence that evening primrose oil and borage oil are not effective for the treatment of AE. There have been no randomized controlled trials on the use of H1 anti-histamines as monotherapy for the treatment of AE. SN - 1365-2230 UR - https://www.unboundmedicine.com/medline/citation/25622761/What's_new_in_atopic_eczema_An_analysis_of_systematic_reviews_published_in_2012_and_2013__Part_2__Treatment_and_prevention_ L2 - https://doi.org/10.1111/ced.12591 DB - PRIME DP - Unbound Medicine ER -