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[Intensity of functional connection between bilateral hemispheres of children with attention-deficit hyperactivity disorder by functional magnetic resonance imaging].
Zhonghua Yi Xue Za Zhi. 2014 Dec 16; 94(46):3649-51.ZY

Abstract

OBJECTIVE

To explore the neural mechanisms of attention-deficit hyperactivity disorder (ADHD) through analyzing the intensity of functional connection between bilateral hemispheres of children with ADHD by resting-state functional magnetic resonance imaging (rs-fMRI).

METHODS

The approach of voxel-mirrored homotopic connectivity (VMHC) was employed to analyze 31 school-age and 31 ADHD children by rs-fMRI scans.

RESULTS

Positively activated brain regions were visualized when comparing ADHD and normal children, suggesting that ADHD children's VMHC scores were higher in bilateral frontal lobe (t = 5.81), bilateral occipital lobe (t = 5.82) and bilateral cerebellar posterior lobe (t = 6.17). Statistically significant differences existed between two groups (FDR correction, Q<0.01).

CONCLUSIONS

The increased intensity of functional connection between bilateral prefrontal lobes in children with ADHD reflects attention disorder and leads to a decline of working memory . The strengthening of bilateral occipital lobes slows down memory process. And the increased intensity of cerebellar connections may damage neural circuits and aggravate ADHD symptoms.

Authors+Show Affiliations

Department of Children's Health Research Center, Changzhou Children's Hospital, Changzhou 213000, China.Department of Children's Health Research Center, Changzhou Children's Hospital, Changzhou 213000, China.Department of Children's Health Research Center, Changzhou Children's Hospital, Changzhou 213000, China.Department of Children's Health Research Center, Changzhou Children's Hospital, Changzhou 213000, China.Department of Children's Health Research Center, Changzhou Children's Hospital, Changzhou 213000, China.Department of Children's Health Research Center, Changzhou Children's Hospital, Changzhou 213000, China.Department of Children's Health Research Center, Changzhou Children's Hospital, Changzhou 213000, China.Department of Children's Health Research Center, Changzhou Children's Hospital, Changzhou 213000, China.Department of Children's Health Research Center, Changzhou Children's Hospital, Changzhou 213000, China.Department of Children's Health Research Center, Changzhou Children's Hospital, Changzhou 213000, China. Email: 50191257@qq.com.

Pub Type(s)

Journal Article

Language

chi

PubMed ID

25622957

Citation

Jiang, Kaihua, et al. "[Intensity of Functional Connection Between Bilateral Hemispheres of Children With Attention-deficit Hyperactivity Disorder By Functional Magnetic Resonance Imaging]." Zhonghua Yi Xue Za Zhi, vol. 94, no. 46, 2014, pp. 3649-51.
Jiang K, Dong X, Gao M, et al. [Intensity of functional connection between bilateral hemispheres of children with attention-deficit hyperactivity disorder by functional magnetic resonance imaging]. Zhonghua Yi Xue Za Zhi. 2014;94(46):3649-51.
Jiang, K., Dong, X., Gao, M., Li, H., Zhang, Q., Yi, Y., Shen, H., Chen, L., Ding, L., & Zheng, A. (2014). [Intensity of functional connection between bilateral hemispheres of children with attention-deficit hyperactivity disorder by functional magnetic resonance imaging]. Zhonghua Yi Xue Za Zhi, 94(46), 3649-51.
Jiang K, et al. [Intensity of Functional Connection Between Bilateral Hemispheres of Children With Attention-deficit Hyperactivity Disorder By Functional Magnetic Resonance Imaging]. Zhonghua Yi Xue Za Zhi. 2014 Dec 16;94(46):3649-51. PubMed PMID: 25622957.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Intensity of functional connection between bilateral hemispheres of children with attention-deficit hyperactivity disorder by functional magnetic resonance imaging]. AU - Jiang,Kaihua, AU - Dong,Xuan, AU - Gao,Min, AU - Li,Hongxin, AU - Zhang,Qinfen, AU - Yi,Yang, AU - Shen,Huijuan, AU - Chen,Lin, AU - Ding,Li, AU - Zheng,Aibin, PY - 2015/1/28/entrez PY - 2015/1/28/pubmed PY - 2015/9/14/medline SP - 3649 EP - 51 JF - Zhonghua yi xue za zhi JO - Zhonghua Yi Xue Za Zhi VL - 94 IS - 46 N2 - OBJECTIVE: To explore the neural mechanisms of attention-deficit hyperactivity disorder (ADHD) through analyzing the intensity of functional connection between bilateral hemispheres of children with ADHD by resting-state functional magnetic resonance imaging (rs-fMRI). METHODS: The approach of voxel-mirrored homotopic connectivity (VMHC) was employed to analyze 31 school-age and 31 ADHD children by rs-fMRI scans. RESULTS: Positively activated brain regions were visualized when comparing ADHD and normal children, suggesting that ADHD children's VMHC scores were higher in bilateral frontal lobe (t = 5.81), bilateral occipital lobe (t = 5.82) and bilateral cerebellar posterior lobe (t = 6.17). Statistically significant differences existed between two groups (FDR correction, Q<0.01). CONCLUSIONS: The increased intensity of functional connection between bilateral prefrontal lobes in children with ADHD reflects attention disorder and leads to a decline of working memory . The strengthening of bilateral occipital lobes slows down memory process. And the increased intensity of cerebellar connections may damage neural circuits and aggravate ADHD symptoms. SN - 0376-2491 UR - https://www.unboundmedicine.com/medline/citation/25622957/[Intensity_of_functional_connection_between_bilateral_hemispheres_of_children_with_attention_deficit_hyperactivity_disorder_by_functional_magnetic_resonance_imaging]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0376-2491&amp;year=2014&amp;vol=94&amp;issue=46&amp;fpage=3649 DB - PRIME DP - Unbound Medicine ER -