Tags

Type your tag names separated by a space and hit enter

PNPLA3 I148M variant in nonalcoholic fatty liver disease: demographic and ethnic characteristics and the role of the variant in nonalcoholic fatty liver fibrosis.
World J Gastroenterol 2015; 21(3):794-802WJ

Abstract

Patatin-like phospholipase domain-containing 3 (PNPLA3 or adiponutrin) displays anabolic and catabolic activities in lipid metabolism, and has been reported to be significantly associated with liver fat content. Various studies have established a strong link between the 148 isoleucine to methionine protein variant (I148M) of PNPLA3 and liver diseases, including nonalcoholic fatty liver disease (NAFLD). However, detailed demographic and ethnic characteristics of the I148M variant and its role in the development of nonalcoholic fatty liver fibrosis have not been fully elucidated. The present review summarizes the current knowledge on the association between the PNPLA3 I148M variant and NAFLD, and especially its role in the development of nonalcoholic fatty liver fibrosis. First, we analyze the impact of demographic and ethnic characteristics of the PNPLA3 I148M variant and the presence of metabolic syndrome on the association between PNPLA3 I148M and NAFLD. Then, we explore the role of the PNPLA3 I148M in the development of nonalcoholic fatty liver fibrosis, and hypothesize the underlying mechanisms by speculating a pro-fibrogenic network. Finally, we briefly highlight future research that may elucidate the specific mechanisms of the PNPLA3 I148M variant in fibrogenesis, which, in turn, provides a theoretical foundation and valuable experimental data for the clinical management of nonalcoholic fatty liver fibrosis.

Authors+Show Affiliations

Li-Zhen Chen, Yong-Ning Xin, Ning Geng, Man Jiang, Ding-Ding Zhang, Shi-Ying Xuan, Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao 266071, Shandong Province, China.Li-Zhen Chen, Yong-Ning Xin, Ning Geng, Man Jiang, Ding-Ding Zhang, Shi-Ying Xuan, Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao 266071, Shandong Province, China.Li-Zhen Chen, Yong-Ning Xin, Ning Geng, Man Jiang, Ding-Ding Zhang, Shi-Ying Xuan, Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao 266071, Shandong Province, China.Li-Zhen Chen, Yong-Ning Xin, Ning Geng, Man Jiang, Ding-Ding Zhang, Shi-Ying Xuan, Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao 266071, Shandong Province, China.Li-Zhen Chen, Yong-Ning Xin, Ning Geng, Man Jiang, Ding-Ding Zhang, Shi-Ying Xuan, Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao 266071, Shandong Province, China.Li-Zhen Chen, Yong-Ning Xin, Ning Geng, Man Jiang, Ding-Ding Zhang, Shi-Ying Xuan, Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao 266071, Shandong Province, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25624712

Citation

Chen, Li-Zhen, et al. "PNPLA3 I148M Variant in Nonalcoholic Fatty Liver Disease: Demographic and Ethnic Characteristics and the Role of the Variant in Nonalcoholic Fatty Liver Fibrosis." World Journal of Gastroenterology, vol. 21, no. 3, 2015, pp. 794-802.
Chen LZ, Xin YN, Geng N, et al. PNPLA3 I148M variant in nonalcoholic fatty liver disease: demographic and ethnic characteristics and the role of the variant in nonalcoholic fatty liver fibrosis. World J Gastroenterol. 2015;21(3):794-802.
Chen, L. Z., Xin, Y. N., Geng, N., Jiang, M., Zhang, D. D., & Xuan, S. Y. (2015). PNPLA3 I148M variant in nonalcoholic fatty liver disease: demographic and ethnic characteristics and the role of the variant in nonalcoholic fatty liver fibrosis. World Journal of Gastroenterology, 21(3), pp. 794-802. doi:10.3748/wjg.v21.i3.794.
Chen LZ, et al. PNPLA3 I148M Variant in Nonalcoholic Fatty Liver Disease: Demographic and Ethnic Characteristics and the Role of the Variant in Nonalcoholic Fatty Liver Fibrosis. World J Gastroenterol. 2015 Jan 21;21(3):794-802. PubMed PMID: 25624712.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - PNPLA3 I148M variant in nonalcoholic fatty liver disease: demographic and ethnic characteristics and the role of the variant in nonalcoholic fatty liver fibrosis. AU - Chen,Li-Zhen, AU - Xin,Yong-Ning, AU - Geng,Ning, AU - Jiang,Man, AU - Zhang,Ding-Ding, AU - Xuan,Shi-Ying, PY - 2014/08/12/received PY - 2014/09/25/revised PY - 2014/10/20/accepted PY - 2015/1/28/entrez PY - 2015/1/28/pubmed PY - 2015/9/15/medline KW - Nonalcoholic fatty liver disease KW - Nonalcoholic fatty liver fibrosis KW - PNPLA3 I148M variant KW - Polymorphism SP - 794 EP - 802 JF - World journal of gastroenterology JO - World J. Gastroenterol. VL - 21 IS - 3 N2 - Patatin-like phospholipase domain-containing 3 (PNPLA3 or adiponutrin) displays anabolic and catabolic activities in lipid metabolism, and has been reported to be significantly associated with liver fat content. Various studies have established a strong link between the 148 isoleucine to methionine protein variant (I148M) of PNPLA3 and liver diseases, including nonalcoholic fatty liver disease (NAFLD). However, detailed demographic and ethnic characteristics of the I148M variant and its role in the development of nonalcoholic fatty liver fibrosis have not been fully elucidated. The present review summarizes the current knowledge on the association between the PNPLA3 I148M variant and NAFLD, and especially its role in the development of nonalcoholic fatty liver fibrosis. First, we analyze the impact of demographic and ethnic characteristics of the PNPLA3 I148M variant and the presence of metabolic syndrome on the association between PNPLA3 I148M and NAFLD. Then, we explore the role of the PNPLA3 I148M in the development of nonalcoholic fatty liver fibrosis, and hypothesize the underlying mechanisms by speculating a pro-fibrogenic network. Finally, we briefly highlight future research that may elucidate the specific mechanisms of the PNPLA3 I148M variant in fibrogenesis, which, in turn, provides a theoretical foundation and valuable experimental data for the clinical management of nonalcoholic fatty liver fibrosis. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/25624712/PNPLA3_I148M_variant_in_nonalcoholic_fatty_liver_disease:_demographic_and_ethnic_characteristics_and_the_role_of_the_variant_in_nonalcoholic_fatty_liver_fibrosis_ L2 - http://www.wjgnet.com/1007-9327/full/v21/i3/794.htm DB - PRIME DP - Unbound Medicine ER -