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Condensin-mediated chromosome organization and gene regulation.
Front Genet 2014; 5:473FG

Abstract

In many organisms sexual fate is determined by a chromosome-based method which entails a difference in sex chromosome-linked gene dosage. Consequently, a gene regulatory mechanism called dosage compensation equalizes X-linked gene expression between the sexes. Dosage compensation initiates as cells transition from pluripotency to differentiation. In Caenorhabditis elegans, dosage compensation is achieved by the dosage compensation complex (DCC) binding to both X chromosomes in hermaphrodites to downregulate gene expression by twofold. The DCC contains a subcomplex (condensin I(DC)) similar to the evolutionarily conserved condensin complexes which play a fundamental role in chromosome dynamics during mitosis. Therefore, mechanisms related to mitotic chromosome condensation are hypothesized to mediate dosage compensation. Consistent with this hypothesis, monomethylation of histone H4 lysine 20 is increased, whereas acetylation of histone H4 lysine 16 is decreased, both on mitotic chromosomes and on interphase dosage compensated X chromosomes in worms. These observations suggest that interphase dosage compensated X chromosomes maintain some characteristics associated with condensed mitotic chromosome. This chromosome state is stably propagated from one cell generation to the next. In this review we will speculate on how the biochemical activities of condensin can achieve both mitotic chromosome compaction and gene repression.

Authors+Show Affiliations

Department of Molecular, Cellular and Developmental Biology, University of Michigan Ann Arbor, MI, USA.Department of Molecular, Cellular and Developmental Biology, University of Michigan Ann Arbor, MI, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25628648

Citation

Lau, Alyssa C., and Györgyi Csankovszki. "Condensin-mediated Chromosome Organization and Gene Regulation." Frontiers in Genetics, vol. 5, 2014, p. 473.
Lau AC, Csankovszki G. Condensin-mediated chromosome organization and gene regulation. Front Genet. 2014;5:473.
Lau, A. C., & Csankovszki, G. (2014). Condensin-mediated chromosome organization and gene regulation. Frontiers in Genetics, 5, p. 473. doi:10.3389/fgene.2014.00473.
Lau AC, Csankovszki G. Condensin-mediated Chromosome Organization and Gene Regulation. Front Genet. 2014;5:473. PubMed PMID: 25628648.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Condensin-mediated chromosome organization and gene regulation. AU - Lau,Alyssa C, AU - Csankovszki,Györgyi, Y1 - 2015/01/13/ PY - 2014/10/30/received PY - 2014/12/19/accepted PY - 2015/1/29/entrez PY - 2015/1/30/pubmed PY - 2015/1/30/medline KW - Caenorhabditis elegans KW - chromatin KW - chromosome condensation KW - condensin KW - dosage compensation KW - epigenetics KW - gene expression KW - interphase chromosome SP - 473 EP - 473 JF - Frontiers in genetics JO - Front Genet VL - 5 N2 - In many organisms sexual fate is determined by a chromosome-based method which entails a difference in sex chromosome-linked gene dosage. Consequently, a gene regulatory mechanism called dosage compensation equalizes X-linked gene expression between the sexes. Dosage compensation initiates as cells transition from pluripotency to differentiation. In Caenorhabditis elegans, dosage compensation is achieved by the dosage compensation complex (DCC) binding to both X chromosomes in hermaphrodites to downregulate gene expression by twofold. The DCC contains a subcomplex (condensin I(DC)) similar to the evolutionarily conserved condensin complexes which play a fundamental role in chromosome dynamics during mitosis. Therefore, mechanisms related to mitotic chromosome condensation are hypothesized to mediate dosage compensation. Consistent with this hypothesis, monomethylation of histone H4 lysine 20 is increased, whereas acetylation of histone H4 lysine 16 is decreased, both on mitotic chromosomes and on interphase dosage compensated X chromosomes in worms. These observations suggest that interphase dosage compensated X chromosomes maintain some characteristics associated with condensed mitotic chromosome. This chromosome state is stably propagated from one cell generation to the next. In this review we will speculate on how the biochemical activities of condensin can achieve both mitotic chromosome compaction and gene repression. SN - 1664-8021 UR - https://www.unboundmedicine.com/medline/citation/25628648/Condensin_mediated_chromosome_organization_and_gene_regulation_ L2 - https://dx.doi.org/10.3389/fgene.2014.00473 DB - PRIME DP - Unbound Medicine ER -