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Effect of maternal iodine supplementation on thyroid function and birth outcome in goiter endemic areas.
Curr Med Res Opin 2015; 31(4):667-74CM

Abstract

OBJECTIVE

The study was undertaken to examine the clinical and endocrine parameters of thyroid in a total of 460 pregnant women belonging to non-goiter areas (group 1; n = 156) and endemic areas without (group 2; n = 154) and with iodine supplementation (group 3; n = 150), and their respective newborns.

METHODS

Women of group 3 with visible goiter were administered two capsules of iodized oil orally each containing 200 mg of iodine, from weeks 6--8 of pregnancy. Blood samples were obtained from all groups during each trimester, at parturition (umbilical cord blood) and after delivery. Serum triiodothyronine (T3), thyroxine (T4) and thyroid stimulating hormone (TSH) levels were measured by specific enzyme immunoassays.

RESULTS

In group 2, serum T4 concentrations were low while T3 and TSH levels were high which showed hypothyroidism in the women of endemic areas. Goiter size decreased in most of the subjects who received a single dose of iodized oil and resulted in increase in serum concentrations of thyroid hormones; whereas, TSH levels decreased. Iodine supplementation also resulted in raised T4 and low TSH levels in the cord blood of neonates. During the course of study, two abortions, three still births and one cretin were reported in group 2; none was reported in group 3; and one still birth was reported in group 1.

CONCLUSIONS

The oral administration of a single dose of iodized oil is capable of correcting iodine deficiency both clinically and endocrinologically in mothers and neonates. Iodine supplementation has the potential to positively impact the birth weight of newborns.

Authors+Show Affiliations

Department of Biochemistry, Quaid-i-Azam University , Islamabad , Pakistan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25629792

Citation

Anees, Mariam, et al. "Effect of Maternal Iodine Supplementation On Thyroid Function and Birth Outcome in Goiter Endemic Areas." Current Medical Research and Opinion, vol. 31, no. 4, 2015, pp. 667-74.
Anees M, Anis RA, Yousaf S, et al. Effect of maternal iodine supplementation on thyroid function and birth outcome in goiter endemic areas. Curr Med Res Opin. 2015;31(4):667-74.
Anees, M., Anis, R. A., Yousaf, S., Murtaza, I., Sultan, A., Arslan, M., & Shahab, M. (2015). Effect of maternal iodine supplementation on thyroid function and birth outcome in goiter endemic areas. Current Medical Research and Opinion, 31(4), pp. 667-74. doi:10.1185/03007995.2015.1011779.
Anees M, et al. Effect of Maternal Iodine Supplementation On Thyroid Function and Birth Outcome in Goiter Endemic Areas. Curr Med Res Opin. 2015;31(4):667-74. PubMed PMID: 25629792.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of maternal iodine supplementation on thyroid function and birth outcome in goiter endemic areas. AU - Anees,Mariam, AU - Anis,Riffat Aysha, AU - Yousaf,Sohail, AU - Murtaza,Iram, AU - Sultan,Aneesa, AU - Arslan,Muhammad, AU - Shahab,Muhammad, Y1 - 2015/02/13/ PY - 2015/1/29/entrez PY - 2015/1/30/pubmed PY - 2015/8/13/medline KW - Endemic KW - Goiter KW - Iodine KW - Pregnancy KW - Thyroid SP - 667 EP - 74 JF - Current medical research and opinion JO - Curr Med Res Opin VL - 31 IS - 4 N2 - OBJECTIVE: The study was undertaken to examine the clinical and endocrine parameters of thyroid in a total of 460 pregnant women belonging to non-goiter areas (group 1; n = 156) and endemic areas without (group 2; n = 154) and with iodine supplementation (group 3; n = 150), and their respective newborns. METHODS: Women of group 3 with visible goiter were administered two capsules of iodized oil orally each containing 200 mg of iodine, from weeks 6--8 of pregnancy. Blood samples were obtained from all groups during each trimester, at parturition (umbilical cord blood) and after delivery. Serum triiodothyronine (T3), thyroxine (T4) and thyroid stimulating hormone (TSH) levels were measured by specific enzyme immunoassays. RESULTS: In group 2, serum T4 concentrations were low while T3 and TSH levels were high which showed hypothyroidism in the women of endemic areas. Goiter size decreased in most of the subjects who received a single dose of iodized oil and resulted in increase in serum concentrations of thyroid hormones; whereas, TSH levels decreased. Iodine supplementation also resulted in raised T4 and low TSH levels in the cord blood of neonates. During the course of study, two abortions, three still births and one cretin were reported in group 2; none was reported in group 3; and one still birth was reported in group 1. CONCLUSIONS: The oral administration of a single dose of iodized oil is capable of correcting iodine deficiency both clinically and endocrinologically in mothers and neonates. Iodine supplementation has the potential to positively impact the birth weight of newborns. SN - 1473-4877 UR - https://www.unboundmedicine.com/medline/citation/25629792/Effect_of_maternal_iodine_supplementation_on_thyroid_function_and_birth_outcome_in_goiter_endemic_areas_ L2 - http://www.tandfonline.com/doi/full/10.1185/03007995.2015.1011779 DB - PRIME DP - Unbound Medicine ER -