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A nutritionally-enhanced oil from transgenic Camelina sativa effectively replaces fish oil as a source of eicosapentaenoic acid for fish.
Sci Rep. 2015 Jan 29; 5:8104.SR

Abstract

For humans a daily intake of up to 500 mg omega-3 (n-3) long-chain polyunsaturated fatty acids (LC-PUFA) is recommended, amounting to an annual requirement of 1.25 million metric tonnes (mt) for a population of 7 billion people. The annual global supply of n-3 LC-PUFA cannot meet this level of requirement and so there is a large gap between supply and demand. The dietary source of n-3 LC-PUFA, fish and seafood, is increasingly provided by aquaculture but using fish oil in feeds to supply n-3 LC-PUFA is unsustainable. Therefore, new sources of n-3 LC-PUFA are required to supply the demand from aquaculture and direct human consumption. One approach is metabolically engineering oilseed crops to synthesize n-3 LC-PUFA in seeds. Transgenic Camelina sativa expressing algal genes was used to produce an oil containing n-3 LC-PUFA to replace fish oil in salmon feeds. The oil had no detrimental effects on fish performance, metabolic responses or the nutritional quality of the fillets of the farmed fish.

Authors+Show Affiliations

Institute of Aquaculture, School of Natural Sciences, University of Stirling, Stirling FK9 4LA, United Kingdom.Institute of Aquaculture, School of Natural Sciences, University of Stirling, Stirling FK9 4LA, United Kingdom.Department of Biological Chemistry and Crop Protection, Rothamsted Research, Harpenden AL5 2JQ, United Kingdom.Department of Biological Chemistry and Crop Protection, Rothamsted Research, Harpenden AL5 2JQ, United Kingdom.Biomar Ltd., North Shore Road, Grangemouth FK3 8UL, United Kingdom.Department of Biological Chemistry and Crop Protection, Rothamsted Research, Harpenden AL5 2JQ, United Kingdom.Institute of Aquaculture, School of Natural Sciences, University of Stirling, Stirling FK9 4LA, United Kingdom.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25632018

Citation

Betancor, M B., et al. "A Nutritionally-enhanced Oil From Transgenic Camelina Sativa Effectively Replaces Fish Oil as a Source of Eicosapentaenoic Acid for Fish." Scientific Reports, vol. 5, 2015, p. 8104.
Betancor MB, Sprague M, Usher S, et al. A nutritionally-enhanced oil from transgenic Camelina sativa effectively replaces fish oil as a source of eicosapentaenoic acid for fish. Sci Rep. 2015;5:8104.
Betancor, M. B., Sprague, M., Usher, S., Sayanova, O., Campbell, P. J., Napier, J. A., & Tocher, D. R. (2015). A nutritionally-enhanced oil from transgenic Camelina sativa effectively replaces fish oil as a source of eicosapentaenoic acid for fish. Scientific Reports, 5, 8104. https://doi.org/10.1038/srep08104
Betancor MB, et al. A Nutritionally-enhanced Oil From Transgenic Camelina Sativa Effectively Replaces Fish Oil as a Source of Eicosapentaenoic Acid for Fish. Sci Rep. 2015 Jan 29;5:8104. PubMed PMID: 25632018.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A nutritionally-enhanced oil from transgenic Camelina sativa effectively replaces fish oil as a source of eicosapentaenoic acid for fish. AU - Betancor,M B, AU - Sprague,M, AU - Usher,S, AU - Sayanova,O, AU - Campbell,P J, AU - Napier,J A, AU - Tocher,D R, Y1 - 2015/01/29/ PY - 2014/09/28/received PY - 2015/01/06/accepted PY - 2015/1/30/entrez PY - 2015/1/30/pubmed PY - 2015/10/21/medline SP - 8104 EP - 8104 JF - Scientific reports JO - Sci Rep VL - 5 N2 - For humans a daily intake of up to 500 mg omega-3 (n-3) long-chain polyunsaturated fatty acids (LC-PUFA) is recommended, amounting to an annual requirement of 1.25 million metric tonnes (mt) for a population of 7 billion people. The annual global supply of n-3 LC-PUFA cannot meet this level of requirement and so there is a large gap between supply and demand. The dietary source of n-3 LC-PUFA, fish and seafood, is increasingly provided by aquaculture but using fish oil in feeds to supply n-3 LC-PUFA is unsustainable. Therefore, new sources of n-3 LC-PUFA are required to supply the demand from aquaculture and direct human consumption. One approach is metabolically engineering oilseed crops to synthesize n-3 LC-PUFA in seeds. Transgenic Camelina sativa expressing algal genes was used to produce an oil containing n-3 LC-PUFA to replace fish oil in salmon feeds. The oil had no detrimental effects on fish performance, metabolic responses or the nutritional quality of the fillets of the farmed fish. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/25632018/A_nutritionally_enhanced_oil_from_transgenic_Camelina_sativa_effectively_replaces_fish_oil_as_a_source_of_eicosapentaenoic_acid_for_fish_ L2 - http://dx.doi.org/10.1038/srep08104 DB - PRIME DP - Unbound Medicine ER -