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Prenatal famine exposure and adult mortality from cancer, cardiovascular disease, and other causes through age 63 years.

Abstract

Nutritional conditions in early life may affect adult health, but prior studies of mortality have been limited to small samples. We evaluated the relationship between pre-/perinatal famine exposure during the Dutch Hunger Winter of 1944-1945 and mortality through age 63 years among 41,096 men born in 1944-1947 and examined at age 18 years for universal military service in the Netherlands. Of these men, 22,952 had been born around the time of the Dutch famine in 6 affected cities; the remainder served as unexposed controls. Cox proportional hazards models were used to estimate hazard ratios for death from cancer, heart disease, other natural causes, and external causes. After 1,853,023 person-years of follow-up, we recorded 1,938 deaths from cancer, 1,040 from heart disease, 1,418 from other natural causes, and 523 from external causes. We found no increase in mortality from cancer or cardiovascular disease after prenatal famine exposure. However, there were increases in mortality from other natural causes (hazard ratio = 1.24, 95% confidence interval: 1.03, 1.49) and external causes (hazard ratio = 1.46, 95% confidence interval: 1.09, 1.97) after famine exposure in the first trimester of gestation. Further follow-up of the cohort is needed to provide more accurate risk estimates of mortality from specific causes of death after nutritional disturbances during gestation and very early life.

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  • Authors

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    Source

    American journal of epidemiology 181:4 2015 Feb 15 pg 271-9

    MeSH

    Adolescent
    Adult
    Birth Weight
    Case-Control Studies
    Female
    Follow-Up Studies
    Heart Diseases
    Humans
    Incidence
    Infant, Newborn
    Male
    Middle Aged
    Neoplasms
    Netherlands
    Pregnancy
    Pregnancy Trimester, First
    Prenatal Exposure Delayed Effects
    Proportional Hazards Models
    Risk Assessment
    Risk Factors
    Starvation

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    25632050

    Citation

    Ekamper, Peter, et al. "Prenatal Famine Exposure and Adult Mortality From Cancer, Cardiovascular Disease, and Other Causes Through Age 63 Years." American Journal of Epidemiology, vol. 181, no. 4, 2015, pp. 271-9.
    Ekamper P, van Poppel F, Stein AD, et al. Prenatal famine exposure and adult mortality from cancer, cardiovascular disease, and other causes through age 63 years. Am J Epidemiol. 2015;181(4):271-9.
    Ekamper, P., van Poppel, F., Stein, A. D., Bijwaard, G. E., & Lumey, L. H. (2015). Prenatal famine exposure and adult mortality from cancer, cardiovascular disease, and other causes through age 63 years. American Journal of Epidemiology, 181(4), pp. 271-9. doi:10.1093/aje/kwu288.
    Ekamper P, et al. Prenatal Famine Exposure and Adult Mortality From Cancer, Cardiovascular Disease, and Other Causes Through Age 63 Years. Am J Epidemiol. 2015 Feb 15;181(4):271-9. PubMed PMID: 25632050.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Prenatal famine exposure and adult mortality from cancer, cardiovascular disease, and other causes through age 63 years. AU - Ekamper,Peter, AU - van Poppel,Frans, AU - Stein,Aryeh D, AU - Bijwaard,Govert E, AU - Lumey,L H, Y1 - 2015/01/27/ PY - 2015/1/30/entrez PY - 2015/1/30/pubmed PY - 2015/4/22/medline KW - Dutch Hunger Winter KW - cohort studies KW - famine KW - fetal origins KW - prenatal exposure delayed effects KW - undernutrition SP - 271 EP - 9 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 181 IS - 4 N2 - Nutritional conditions in early life may affect adult health, but prior studies of mortality have been limited to small samples. We evaluated the relationship between pre-/perinatal famine exposure during the Dutch Hunger Winter of 1944-1945 and mortality through age 63 years among 41,096 men born in 1944-1947 and examined at age 18 years for universal military service in the Netherlands. Of these men, 22,952 had been born around the time of the Dutch famine in 6 affected cities; the remainder served as unexposed controls. Cox proportional hazards models were used to estimate hazard ratios for death from cancer, heart disease, other natural causes, and external causes. After 1,853,023 person-years of follow-up, we recorded 1,938 deaths from cancer, 1,040 from heart disease, 1,418 from other natural causes, and 523 from external causes. We found no increase in mortality from cancer or cardiovascular disease after prenatal famine exposure. However, there were increases in mortality from other natural causes (hazard ratio = 1.24, 95% confidence interval: 1.03, 1.49) and external causes (hazard ratio = 1.46, 95% confidence interval: 1.09, 1.97) after famine exposure in the first trimester of gestation. Further follow-up of the cohort is needed to provide more accurate risk estimates of mortality from specific causes of death after nutritional disturbances during gestation and very early life. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/25632050/Prenatal_famine_exposure_and_adult_mortality_from_cancer_cardiovascular_disease_and_other_causes_through_age_63_years_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwu288 DB - PRIME DP - Unbound Medicine ER -