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Observational and ecological studies of dietary advanced glycation end products in national diets and Alzheimer's disease incidence and prevalence.

Abstract

BACKGROUND

Considerable evidence indicates that diet is an important risk-modifying factor for Alzheimer's disease (AD). Evidence is also mounting that dietary advanced glycation end products (AGEs) are important risk factors for AD.

OBJECTIVE

This study strives to determine whether estimated dietary AGEs estimated from national diets and epidemiological studies are associated with increased AD incidence.

METHODS

We estimated values of dietary AGEs using values in a published paper. We estimated intake of dietary AGEs from the Washington Heights-Inwood Community Aging Project (WHICAP) 1992 and 1999 cohort studies, which investigated how the Mediterranean diet (MeDi) affected AD incidence. Further, AD prevalence data came from three ecological studies and included data from 11 countries for 1977-1993, seven developing countries for 1995-2005, and Japan for 1985-2008. The analysis used dietary AGE values from 20 years before the AD prevalence data.

RESULTS

Meat was always the food with the largest amount of AGEs. Other foods with significant AGEs included fish, cheese, vegetables, and vegetable oil. High MeDi adherence results in lower meat and dairy intake, which possess high AGE content. By using two different models to extrapolate dietary AGE intake in the WHICAP 1992 and 1999 cohort studies, we showed that reduced dietary AGE significantly correlates with reduced AD incidence. For the ecological studies, estimates of dietary AGEs in the national diets corresponded well with AD prevalence data even though the cooking methods were not well known.

CONCLUSION

Dietary AGEs appear to be important risk factors for AD.

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  • Authors+Show Affiliations

    ,

    EA 3808, Medical School, University of Poitiers, Poitiers, France.

    Sunlight, Nutrition, and Health Research Center, San Francisco, CA, USA.

    Source

    MeSH

    Alzheimer Disease
    Cohort Studies
    Cross-Cultural Comparison
    Dietary Proteins
    Ecology
    Feeding Behavior
    Female
    Glycation End Products, Advanced
    Humans
    Incidence
    Male
    Nutritional Physiological Phenomena

    Pub Type(s)

    Journal Article
    Observational Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25633677

    Citation

    Perrone, Lorena, and William B. Grant. "Observational and Ecological Studies of Dietary Advanced Glycation End Products in National Diets and Alzheimer's Disease Incidence and Prevalence." Journal of Alzheimer's Disease : JAD, vol. 45, no. 3, 2015, pp. 965-79.
    Perrone L, Grant WB. Observational and ecological studies of dietary advanced glycation end products in national diets and Alzheimer's disease incidence and prevalence. J Alzheimers Dis. 2015;45(3):965-79.
    Perrone, L., & Grant, W. B. (2015). Observational and ecological studies of dietary advanced glycation end products in national diets and Alzheimer's disease incidence and prevalence. Journal of Alzheimer's Disease : JAD, 45(3), pp. 965-79. doi:10.3233/JAD-140720.
    Perrone L, Grant WB. Observational and Ecological Studies of Dietary Advanced Glycation End Products in National Diets and Alzheimer's Disease Incidence and Prevalence. J Alzheimers Dis. 2015;45(3):965-79. PubMed PMID: 25633677.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Observational and ecological studies of dietary advanced glycation end products in national diets and Alzheimer's disease incidence and prevalence. AU - Perrone,Lorena, AU - Grant,William B, PY - 2015/1/31/entrez PY - 2015/1/31/pubmed PY - 2016/1/20/medline KW - Advanced glycation end products KW - Alzheimer's disease KW - Japan KW - MeDi KW - cheese KW - diet KW - ecological KW - fish KW - meat KW - mediterranean diet SP - 965 EP - 79 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 45 IS - 3 N2 - BACKGROUND: Considerable evidence indicates that diet is an important risk-modifying factor for Alzheimer's disease (AD). Evidence is also mounting that dietary advanced glycation end products (AGEs) are important risk factors for AD. OBJECTIVE: This study strives to determine whether estimated dietary AGEs estimated from national diets and epidemiological studies are associated with increased AD incidence. METHODS: We estimated values of dietary AGEs using values in a published paper. We estimated intake of dietary AGEs from the Washington Heights-Inwood Community Aging Project (WHICAP) 1992 and 1999 cohort studies, which investigated how the Mediterranean diet (MeDi) affected AD incidence. Further, AD prevalence data came from three ecological studies and included data from 11 countries for 1977-1993, seven developing countries for 1995-2005, and Japan for 1985-2008. The analysis used dietary AGE values from 20 years before the AD prevalence data. RESULTS: Meat was always the food with the largest amount of AGEs. Other foods with significant AGEs included fish, cheese, vegetables, and vegetable oil. High MeDi adherence results in lower meat and dairy intake, which possess high AGE content. By using two different models to extrapolate dietary AGE intake in the WHICAP 1992 and 1999 cohort studies, we showed that reduced dietary AGE significantly correlates with reduced AD incidence. For the ecological studies, estimates of dietary AGEs in the national diets corresponded well with AD prevalence data even though the cooking methods were not well known. CONCLUSION: Dietary AGEs appear to be important risk factors for AD. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/25633677/Observational_and_ecological_studies_of_dietary_advanced_glycation_end_products_in_national_diets_and_Alzheimer's_disease_incidence_and_prevalence_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-140720 DB - PRIME DP - Unbound Medicine ER -