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The role of the histone demethylase KDM4A in cancer.
Cancer Genet. 2015 May; 208(5):215-24.CG

Abstract

Histone posttranslational modifications are important components of epigenetic regulation. One extensively studied modification is the methylation of lysine residues. These modifications were thought to be irreversible. However, several proteins with histone lysine demethylase functions have been discovered and characterized. Among these proteins, KDM4A is the first histone lysine demethylase shown to demethylate trimethylated residues. This enzyme plays an important role in gene expression, cellular differentiation, and animal development. Recently, it has also been shown to be involved in cancer. In this review, we focus on describing the structure, mechanisms, and function of KDM4A. We primarily discuss the role of KDM4A in cancer development and the importance of KDM4A as a potential therapeutic target.

Authors+Show Affiliations

Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico.Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico.Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico.Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico.Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología-Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico. Electronic address: ctcf@ciencias.unam.mx.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25633974

Citation

Guerra-Calderas, Lissania, et al. "The Role of the Histone Demethylase KDM4A in Cancer." Cancer Genetics, vol. 208, no. 5, 2015, pp. 215-24.
Guerra-Calderas L, González-Barrios R, Herrera LA, et al. The role of the histone demethylase KDM4A in cancer. Cancer Genet. 2015;208(5):215-24.
Guerra-Calderas, L., González-Barrios, R., Herrera, L. A., Cantú de León, D., & Soto-Reyes, E. (2015). The role of the histone demethylase KDM4A in cancer. Cancer Genetics, 208(5), 215-24. https://doi.org/10.1016/j.cancergen.2014.11.001
Guerra-Calderas L, et al. The Role of the Histone Demethylase KDM4A in Cancer. Cancer Genet. 2015;208(5):215-24. PubMed PMID: 25633974.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of the histone demethylase KDM4A in cancer. AU - Guerra-Calderas,Lissania, AU - González-Barrios,Rodrigo, AU - Herrera,Luis A, AU - Cantú de León,David, AU - Soto-Reyes,Ernesto, Y1 - 2014/11/20/ PY - 2014/04/14/received PY - 2014/10/20/revised PY - 2014/11/05/accepted PY - 2015/1/31/entrez PY - 2015/1/31/pubmed PY - 2015/8/25/medline KW - Jmjd2A KW - KDM4A KW - cancer KW - histone demethylase KW - therapeutic target SP - 215 EP - 24 JF - Cancer genetics JO - Cancer Genet VL - 208 IS - 5 N2 - Histone posttranslational modifications are important components of epigenetic regulation. One extensively studied modification is the methylation of lysine residues. These modifications were thought to be irreversible. However, several proteins with histone lysine demethylase functions have been discovered and characterized. Among these proteins, KDM4A is the first histone lysine demethylase shown to demethylate trimethylated residues. This enzyme plays an important role in gene expression, cellular differentiation, and animal development. Recently, it has also been shown to be involved in cancer. In this review, we focus on describing the structure, mechanisms, and function of KDM4A. We primarily discuss the role of KDM4A in cancer development and the importance of KDM4A as a potential therapeutic target. SN - 2210-7762 UR - https://www.unboundmedicine.com/medline/citation/25633974/The_role_of_the_histone_demethylase_KDM4A_in_cancer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2210-7762(14)00245-2 DB - PRIME DP - Unbound Medicine ER -